196 related articles for article (PubMed ID: 20942408)
1. Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation.
Lajiness JP; Robertson WM; Dunwiddie I; Broward MA; Vielhauer GA; Weir SJ; Boger DL
J Med Chem; 2010 Nov; 53(21):7731-8. PubMed ID: 20942408
[TBL] [Abstract][Full Text] [Related]
2. A unique class of duocarmycin and CC-1065 analogues subject to reductive activation.
Jin W; Trzupek JD; Rayl TJ; Broward MA; Vielhauer GA; Weir SJ; Hwang I; Boger DL
J Am Chem Soc; 2007 Dec; 129(49):15391-7. PubMed ID: 18020335
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.
Zhao RY; Erickson HK; Leece BA; Reid EE; Goldmacher VS; Lambert JM; Chari RV
J Med Chem; 2012 Jan; 55(2):766-82. PubMed ID: 22148292
[TBL] [Abstract][Full Text] [Related]
4. Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs.
Wolfe AL; Duncan KK; Parelkar NK; Brown D; Vielhauer GA; Boger DL
J Med Chem; 2013 May; 56(10):4104-15. PubMed ID: 23627265
[TBL] [Abstract][Full Text] [Related]
5. Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy.
Stevenson RJ; Denny WA; Tercel M; Pruijn FB; Ashoorzadeh A
J Med Chem; 2012 Mar; 55(6):2780-802. PubMed ID: 22339090
[TBL] [Abstract][Full Text] [Related]
6. Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers.
Vielhauer GA; Swink M; Parelkar NK; Lajiness JP; Wolfe AL; Boger D
Cancer Biol Ther; 2013 Jun; 14(6):527-36. PubMed ID: 23760495
[TBL] [Abstract][Full Text] [Related]
7. Duocarmycins--natures prodrugs?
Searcey M
Curr Pharm Des; 2002; 8(15):1375-89. PubMed ID: 12052214
[TBL] [Abstract][Full Text] [Related]
8. Asymmetric synthesis of a CBI-based cyclic N-acyl O-amino phenol duocarmycin prodrug.
Uematsu M; Boger DL
J Org Chem; 2014 Oct; 79(20):9699-703. PubMed ID: 25247380
[TBL] [Abstract][Full Text] [Related]
9. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents.
Patil PC; Satam V; Lee M
Anticancer Agents Med Chem; 2015; 15(5):616-30. PubMed ID: 25511515
[TBL] [Abstract][Full Text] [Related]
10. The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy.
Stevenson RJ; Denny WA; Ashoorzadeh A; Pruijn FB; van Leeuwen WF; Tercel M
Bioorg Med Chem; 2011 Oct; 19(20):5989-98. PubMed ID: 21920763
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders.
Baraldi PG; Balboni G; Pavani MG; Spalluto G; Tabrizi MA; Clercq ED; Balzarini J; Bando T; Sugiyama H; Romagnoli R
J Med Chem; 2001 Aug; 44(16):2536-43. PubMed ID: 11472207
[TBL] [Abstract][Full Text] [Related]
12. Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.
Howard TT; Lingerfelt BM; Purnell BL; Scott AE; Price CA; Townes HM; McNulty L; Handl HL; Summerville K; Hudson SJ; Bowen JP; Kiakos K; Hartley JA; Lee M
Bioorg Med Chem; 2002 Sep; 10(9):2941-52. PubMed ID: 12110316
[TBL] [Abstract][Full Text] [Related]
13. Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.
Boger DL; Hughes TV; Hedrick MP
J Org Chem; 2001 Apr; 66(7):2207-16. PubMed ID: 11281757
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and evaluation of stable bidentate transition metal complexes of 1-(chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as hypoxia selective cytotoxins.
Milbank JB; Stevenson RJ; Ware DC; Chang JY; Tercel M; Ahn GO; Wilson WR; Denny WA
J Med Chem; 2009 Nov; 52(21):6822-34. PubMed ID: 19821576
[TBL] [Abstract][Full Text] [Related]
15. Novel (S)-(-)- and R-(+)-seco-iso-cyclopropylfurano[e]indoline-5,6,7-trimethoxyindole-2-carboxamide (iso-CFI) analogs of duocarmycin C2: synthesis and biological evaluation.
Purnell B; Lingerfelt B; Scott A; Townes H; Summerville K; Hudson S; Kiakos K; Hartley JA; Lee M
Med Chem; 2006 Mar; 2(2):139-46. PubMed ID: 16787363
[TBL] [Abstract][Full Text] [Related]
16. Selective treatment of cancer: synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins.
Tietze LF; Major F; Schuberth I; Spiegl DA; Krewer B; Maksimenka K; Bringmann G; Magull J
Chemistry; 2007; 13(16):4396-409. PubMed ID: 17455190
[TBL] [Abstract][Full Text] [Related]
17. Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity.
Boger DL; Searcey M; Tse WC; Jin Q
Bioorg Med Chem Lett; 2000 Mar; 10(5):495-8. PubMed ID: 10743956
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and evaluation of a thio analogue of duocarmycin SA.
MacMillan KS; Lajiness JP; Cara CL; Romagnoli R; Robertson WM; Hwang I; Baraldi PG; Boger DL
Bioorg Med Chem Lett; 2009 Dec; 19(24):6962-5. PubMed ID: 19879753
[TBL] [Abstract][Full Text] [Related]
19. 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits.
Atwell GJ; Milbank JJ; Wilson WR; Hogg A; Denny WA
J Med Chem; 1999 Aug; 42(17):3400-11. PubMed ID: 10464026
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
Hay MP; Anderson RF; Ferry DM; Wilson WR; Denny WA
J Med Chem; 2003 Dec; 46(25):5533-45. PubMed ID: 14640560
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]