These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

206 related articles for article (PubMed ID: 20956357)

  • 1. Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9.
    Debebe Z; Ammosova T; Breuer D; Lovejoy DB; Kalinowski DS; Kumar K; Jerebtsova M; Ray P; Kashanchi F; Gordeuk VR; Richardson DR; Nekhai S
    Mol Pharmacol; 2011 Jan; 79(1):185-96. PubMed ID: 20956357
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IκB-α expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription.
    Kumari N; Iordanskiy S; Kovalskyy D; Breuer D; Niu X; Lin X; Xu M; Gavrilenko K; Kashanchi F; Dhawan S; Nekhai S
    Antimicrob Agents Chemother; 2014 Nov; 58(11):6558-71. PubMed ID: 25155598
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Iron chelators ICL670 and 311 inhibit HIV-1 transcription.
    Debebe Z; Ammosova T; Jerebtsova M; Kurantsin-Mills J; Niu X; Charles S; Richardson DR; Ray PE; Gordeuk VR; Nekhai S
    Virology; 2007 Oct; 367(2):324-33. PubMed ID: 17631934
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.
    Breuer D; Kotelkin A; Ammosova T; Kumari N; Ivanov A; Ilatovskiy AV; Beullens M; Roane PR; Bollen M; Petukhov MG; Kashanchi F; Nekhai S
    Retrovirology; 2012 Nov; 9():94. PubMed ID: 23140174
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers.
    Debebe Z; Nekhai S; Ashenafi M; Lovejoy DB; Kalinowski DS; Gordeuk VR; Byrnes WM; Richardson DR; Karla PK
    J Chromatogr B Analyt Technol Biomed Life Sci; 2012 Oct; 906():25-32. PubMed ID: 22954966
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.
    Yu Y; Suryo Rahmanto Y; Hawkins CL; Richardson DR
    Mol Pharmacol; 2011 Jun; 79(6):921-31. PubMed ID: 21389104
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer.
    Merlot AM; Pantarat N; Lovejoy DB; Kalinowski DS; Richardson DR
    Mol Pharmacol; 2010 Oct; 78(4):675-84. PubMed ID: 20605952
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
    Kalinowski DS; Yu Y; Sharpe PC; Islam M; Liao YT; Lovejoy DB; Kumar N; Bernhardt PV; Richardson DR
    J Med Chem; 2007 Jul; 50(15):3716-29. PubMed ID: 17602603
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Transcriptional regulation of the cyclin-dependent kinase inhibitor, p21
    Moussa RS; Kovacevic Z; Bae DH; Lane DJR; Richardson DR
    Biochim Biophys Acta Gen Subj; 2018 Mar; 1862(3):761-774. PubMed ID: 29032246
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Regulation of HIV-1 transcription at 3% versus 21% oxygen concentration.
    Charles S; Ammosova T; Cardenas J; Foster A; Rotimi J; Jerebtsova M; Ayodeji AA; Niu X; Ray PE; Gordeuk VR; Kashanchi F; Nekhai S
    J Cell Physiol; 2009 Nov; 221(2):469-79. PubMed ID: 19626680
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Protein Phosphatase-1 -targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals.
    Lin X; Ammosova T; Kumari N; Nekhai S
    Curr Pharm Des; 2017; 23(28):4122-4132. PubMed ID: 28677499
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Novel "hybrid" iron chelators derived from aroylhydrazones and thiosemicarbazones demonstrate selective antiproliferative activity against tumor cells.
    Lovejoy DB; Richardson DR
    Blood; 2002 Jul; 100(2):666-76. PubMed ID: 12091363
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.
    Yu Y; Suryo Rahmanto Y; Richardson DR
    Br J Pharmacol; 2012 Jan; 165(1):148-66. PubMed ID: 21658021
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect.
    Quach P; Gutierrez E; Basha MT; Kalinowski DS; Sharpe PC; Lovejoy DB; Bernhardt PV; Jansson PJ; Richardson DR
    Mol Pharmacol; 2012 Jul; 82(1):105-14. PubMed ID: 22508546
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites.
    Potůčková E; Roh J; Macháček M; Sahni S; Stariat J; Šesták V; Jansová H; Hašková P; Jirkovská A; Vávrová K; Kovaříková P; Kalinowski DS; Richardson DR; Šimůnek T
    PLoS One; 2015; 10(10):e0139929. PubMed ID: 26460540
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types.
    Moussa RS; Kovacevic Z; Richardson DR
    Oncotarget; 2015 Oct; 6(30):29694-711. PubMed ID: 26335183
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: structure-activity relationship studies on their anti-proliferative and iron chelation efficacy.
    Lukmantara AY; Kalinowski DS; Kumar N; Richardson DR
    J Inorg Biochem; 2014 Dec; 141():43-54. PubMed ID: 25217717
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.
    Richardson DR; Kalinowski DS; Richardson V; Sharpe PC; Lovejoy DB; Islam M; Bernhardt PV
    J Med Chem; 2009 Mar; 52(5):1459-70. PubMed ID: 19216562
    [TBL] [Abstract][Full Text] [Related]  

  • 19. HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription.
    Ivanov A; Lin X; Ammosova T; Ilatovskiy AV; Kumari N; Lassiter H; Afangbedji N; Niu X; Petukhov MG; Nekhai S
    Retrovirology; 2018 May; 15(1):39. PubMed ID: 29792216
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the treatment of pancreatic cancer.
    Kovacevic Z; Chikhani S; Lovejoy DB; Richardson DR
    Mol Pharmacol; 2011 Oct; 80(4):598-609. PubMed ID: 21719465
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.