BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

368 related articles for article (PubMed ID: 20960568)

  • 1. Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability.
    Goldberg DS; Bishop SM; Shah AU; Sathish HA
    J Pharm Sci; 2011 Apr; 100(4):1306-15. PubMed ID: 20960568
    [TBL] [Abstract][Full Text] [Related]  

  • 2. High-throughput screening of formulations to optimize the thermal stability of a therapeutic monoclonal antibody.
    Niedziela-Majka A; Kan E; Weissburg P; Mehra U; Sellers S; Sakowicz R
    J Biomol Screen; 2015 Apr; 20(4):552-9. PubMed ID: 25385011
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Examination of thermal unfolding and aggregation profiles of a series of developable therapeutic monoclonal antibodies.
    Brader ML; Estey T; Bai S; Alston RW; Lucas KK; Lantz S; Landsman P; Maloney KM
    Mol Pharm; 2015 Apr; 12(4):1005-17. PubMed ID: 25687223
    [TBL] [Abstract][Full Text] [Related]  

  • 4. DSF method optimization and its application in predicting protein thermal aggregation kinetics.
    Shi S; Semple A; Cheung J; Shameem M
    J Pharm Sci; 2013 Aug; 102(8):2471-83. PubMed ID: 23754479
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Utility of High Throughput Screening Techniques to Predict Stability of Monoclonal Antibody Formulations During Early Stage Development.
    Goldberg DS; Lewus RA; Esfandiary R; Farkas DC; Mody N; Day KJ; Mallik P; Tracka MB; Sealey SK; Samra HS
    J Pharm Sci; 2017 Aug; 106(8):1971-1977. PubMed ID: 28456733
    [TBL] [Abstract][Full Text] [Related]  

  • 6. High throughput thermostability screening of monoclonal antibody formulations.
    He F; Hogan S; Latypov RF; Narhi LO; Razinkov VI
    J Pharm Sci; 2010 Apr; 99(4):1707-20. PubMed ID: 19780136
    [TBL] [Abstract][Full Text] [Related]  

  • 7. High throughput formulation screening for global aggregation behaviors of three monoclonal antibodies.
    Li Y; Mach H; Blue JT
    J Pharm Sci; 2011 Jun; 100(6):2120-35. PubMed ID: 21491438
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Application of a high-throughput relative chemical stability assay to screen therapeutic protein formulations by assessment of conformational stability and correlation to aggregation propensity.
    Rizzo JM; Shi S; Li Y; Semple A; Esposito JJ; Yu S; Richardson D; Antochshuk V; Shameem M
    J Pharm Sci; 2015 May; 104(5):1632-40. PubMed ID: 25757872
    [TBL] [Abstract][Full Text] [Related]  

  • 9. High Throughput Differential Scanning Fluorimetry (DSF) Formulation Screening with Complementary Dyes to Assess Protein Unfolding and Aggregation in Presence of Surfactants.
    McClure SM; Ahl PL; Blue JT
    Pharm Res; 2018 Mar; 35(4):81. PubMed ID: 29508082
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Temperature-ramped studies on the aggregation, unfolding, and interaction of a therapeutic monoclonal antibody.
    Menzen T; Friess W
    J Pharm Sci; 2014 Feb; 103(2):445-55. PubMed ID: 24382634
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Thermodynamic Unfolding and Aggregation Fingerprints of Monoclonal Antibodies Using Thermal Profiling.
    Melien R; Garidel P; Hinderberger D; Blech M
    Pharm Res; 2020 Apr; 37(4):78. PubMed ID: 32236701
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Orthogonal Methods for Characterizing the Unfolding of Therapeutic Monoclonal Antibodies: Differential Scanning Calorimetry, Isothermal Chemical Denaturation, and Intrinsic Fluorescence with Concomitant Static Light Scattering.
    Temel DB; Landsman P; Brader ML
    Methods Enzymol; 2016; 567():359-89. PubMed ID: 26794361
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A comparison of biophysical characterization techniques in predicting monoclonal antibody stability.
    Thiagarajan G; Semple A; James JK; Cheung JK; Shameem M
    MAbs; 2016; 8(6):1088-97. PubMed ID: 27210456
    [TBL] [Abstract][Full Text] [Related]  

  • 14. High Throughput Prediction Approach for Monoclonal Antibody Aggregation at High Concentration.
    Zidar M; Šušterič A; Ravnik M; Kuzman D
    Pharm Res; 2017 Sep; 34(9):1831-1839. PubMed ID: 28593474
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Nonnative aggregation of an IgG1 antibody in acidic conditions: part 1. Unfolding, colloidal interactions, and formation of high-molecular-weight aggregates.
    Brummitt RK; Nesta DP; Chang L; Chase SF; Laue TM; Roberts CJ
    J Pharm Sci; 2011 Jun; 100(6):2087-103. PubMed ID: 21213308
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Formulation design and high-throughput excipient selection based on structural integrity and conformational stability of dilute and highly concentrated IgG1 monoclonal antibody solutions.
    Bhambhani A; Kissmann JM; Joshi SB; Volkin DB; Kashi RS; Middaugh CR
    J Pharm Sci; 2012 Mar; 101(3):1120-35. PubMed ID: 22147527
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Isothermal chemical denaturation as a complementary tool to overcome limitations of thermal differential scanning fluorimetry in predicting physical stability of protein formulations.
    Svilenov H; Markoja U; Winter G
    Eur J Pharm Biopharm; 2018 Apr; 125():106-113. PubMed ID: 29329817
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Probing Thermal Stability of Proteins with Temperature Scanning Viscometer.
    Jiang B; Jain A; Lu Y; Hoag SW
    Mol Pharm; 2019 Aug; 16(8):3687-3693. PubMed ID: 31306023
    [TBL] [Abstract][Full Text] [Related]  

  • 19. High throughput methods of assessing protein stability and aggregation.
    Senisterra GA; Finerty PJ
    Mol Biosyst; 2009 Mar; 5(3):217-23. PubMed ID: 19225610
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Simultaneous High-Throughput Conformational and Colloidal Stability Screening Using a Fluorescent Molecular Rotor Dye, 4-(4-(Dimethylamino)styryl)-N-Methylpyridinium Iodide (DASPMI).
    Wong JJ; Wright SK; Ghozalli I; Mehra R; Furuya K; Katayama DS
    J Biomol Screen; 2016 Sep; 21(8):842-50. PubMed ID: 27138878
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.