BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

200 related articles for article (PubMed ID: 20961062)

  • 21. Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.
    Markwalder JA; Arnone MR; Benfield PA; Boisclair M; Burton CR; Chang CH; Cox SS; Czerniak PM; Dean CL; Doleniak D; Grafstrom R; Harrison BA; Kaltenbach RF; Nugiel DA; Rossi KA; Sherk SR; Sisk LM; Stouten P; Trainor GL; Worland P; Seitz SP
    J Med Chem; 2004 Nov; 47(24):5894-911. PubMed ID: 15537345
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors.
    Hu H; Wang X; Chan GK; Chang JH; Do S; Drummond J; Ebens A; Lee W; Ly J; Lyssikatos JP; Murray J; Moffat JG; Chao Q; Tsui V; Wallweber H; Kolesnikov A
    Bioorg Med Chem Lett; 2015 Nov; 25(22):5258-64. PubMed ID: 26459208
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex.
    Echalier A; Bettayeb K; Ferandin Y; Lozach O; Clément M; Valette A; Liger F; Marquet B; Morris JC; Endicott JA; Joseph B; Meijer L
    J Med Chem; 2008 Feb; 51(4):737-51. PubMed ID: 18232649
    [TBL] [Abstract][Full Text] [Related]  

  • 24. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines.
    Zask A; Verheijen JC; Curran K; Kaplan J; Richard DJ; Nowak P; Malwitz DJ; Brooijmans N; Bard J; Svenson K; Lucas J; Toral-Barza L; Zhang WG; Hollander I; Gibbons JJ; Abraham RT; Ayral-Kaloustian S; Mansour TS; Yu K
    J Med Chem; 2009 Aug; 52(16):5013-6. PubMed ID: 19645448
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Bisarylureas Based on 1H-Pyrazolo[3,4-d]pyrimidine Scaffold as Novel Pan-RAF Inhibitors with Potent Anti-Proliferative Activities: Structure-Based Design, Synthesis, Biological Evaluation and Molecular Modelling Studies.
    Fu Y; Wang Y; Wan S; Li Z; Wang G; Zhang J; Wu X
    Molecules; 2017 Mar; 22(4):. PubMed ID: 28353640
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Synthesis and anti-tumor activities of novel pyrazolo[1,5-a]pyrimidines.
    Li J; Zhao YF; Zhao XL; Yuan XY; Gong P
    Arch Pharm (Weinheim); 2006 Nov; 339(11):593-7. PubMed ID: 17036367
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Synthesis and biological evaluation of pyrazolo[4,3-d]pyrimidine analogues.
    Yuan L; Song C; Li C; Li Y; Dong L; Yin S
    Eur J Med Chem; 2013 Sep; 67():152-7. PubMed ID: 23851116
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Novel pyrazolopyrimidine derivatives as tyrosine kinase inhibitors with antitumoral activity in vitro and in vivo in papillary dedifferentiated thyroid cancer.
    Antonelli A; Bocci G; La Motta C; Ferrari SM; Fallahi P; Fioravanti A; Sartini S; Minuto M; Piaggi S; Corti A; Alì G; Berti P; Fontanini G; Danesi R; Da Settimo F; Miccoli P
    J Clin Endocrinol Metab; 2011 Feb; 96(2):E288-96. PubMed ID: 21147882
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.
    Okaniwa M; Hirose M; Imada T; Ohashi T; Hayashi Y; Miyazaki T; Arita T; Yabuki M; Kakoi K; Kato J; Takagi T; Kawamoto T; Yao S; Sumita A; Tsutsumi S; Tottori T; Oki H; Sang BC; Yano J; Aertgeerts K; Yoshida S; Ishikawa T
    J Med Chem; 2012 Apr; 55(7):3452-78. PubMed ID: 22376051
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Identification of type II inhibitors targeting BRAF using privileged pharmacophores.
    Zhang Q; Wang J; Wang F; Chen X; He Y; You Q; Zhou H
    Chem Biol Drug Des; 2014 Jan; 83(1):27-36. PubMed ID: 24164966
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Pyridoimidazolones as novel potent inhibitors of v-Raf murine sarcoma viral oncogene homologue B1 (BRAF).
    Niculescu-Duvaz D; Gaulon C; Dijkstra HP; Niculescu-Duvaz I; Zambon A; Ménard D; Suijkerbuijk BM; Nourry A; Davies L; Manne H; Friedlos F; Ogilvie L; Hedley D; Whittaker S; Kirk R; Gill A; Taylor RD; Raynaud FI; Moreno-Farre J; Marais R; Springer CJ
    J Med Chem; 2009 Apr; 52(8):2255-64. PubMed ID: 19323560
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation.
    Carraro F; Naldini A; Pucci A; Locatelli GA; Maga G; Schenone S; Bruno O; Ranise A; Bondavalli F; Brullo C; Fossa P; Menozzi G; Mosti L; Modugno M; Tintori C; Manetti F; Botta M
    J Med Chem; 2006 Mar; 49(5):1549-61. PubMed ID: 16509573
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Design, Synthesis, and Structure-Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src Inhibitors with Potent Activities in Models of Triple Negative Breast Cancer.
    Zhang CH; Zheng MW; Li YP; Lin XD; Huang M; Zhong L; Li GB; Zhang RJ; Lin WT; Jiao Y; Wu XA; Yang J; Xiang R; Chen LJ; Zhao YL; Cheng W; Wei YQ; Yang SY
    J Med Chem; 2015 May; 58(9):3957-74. PubMed ID: 25835317
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazol-3-yl)pyridines as potential antitumor agents.
    Qin M; Zhai X; Xie H; Ma J; Lu K; Wang Y; Wang L; Gu Y; Gong P
    Eur J Med Chem; 2014 Jun; 81():47-58. PubMed ID: 24826815
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Synthesis and antiproliferative activity of triazenoindazoles and triazenopyrazoles: a comparative study.
    Daidone G; Raffa D; Maggio B; Valeria Raimondi M; Plescia F; Schillaci D
    Eur J Med Chem; 2004 Mar; 39(3):219-24. PubMed ID: 15051169
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists.
    Guo C; Linton A; Kephart S; Ornelas M; Pairish M; Gonzalez J; Greasley S; Nagata A; Burke BJ; Edwards M; Hosea N; Kang P; Hu W; Engebretsen J; Briere D; Shi M; Gukasyan H; Richardson P; Dack K; Underwood T; Johnson P; Morell A; Felstead R; Kuruma H; Matsimoto H; Zoubeidi A; Gleave M; Los G; Fanjul AN
    J Med Chem; 2011 Nov; 54(21):7693-704. PubMed ID: 21936524
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
    Zehnder L; Bennett M; Meng J; Huang B; Ninkovic S; Wang F; Braganza J; Tatlock J; Jewell T; Zhou JZ; Burke B; Wang J; Maegley K; Mehta PP; Yin MJ; Gajiwala KS; Hickey MJ; Yamazaki S; Smith E; Kang P; Sistla A; Dovalsantos E; Gehring MR; Kania R; Wythes M; Kung PP
    J Med Chem; 2011 May; 54(9):3368-85. PubMed ID: 21438541
    [TBL] [Abstract][Full Text] [Related]  

  • 38. New diarylureas and diarylamides containing 1,3,4-triarylpyrazole scaffold: Synthesis, antiproliferative evaluation against melanoma cell lines, ERK kinase inhibition, and molecular docking studies.
    Choi WK; El-Gamal MI; Choi HS; Baek D; Oh CH
    Eur J Med Chem; 2011 Dec; 46(12):5754-62. PubMed ID: 22014559
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study.
    Radi M; Dreassi E; Brullo C; Crespan E; Tintori C; Bernardo V; Valoti M; Zamperini C; Daigl H; Musumeci F; Carraro F; Naldini A; Filippi I; Maga G; Schenone S; Botta M
    J Med Chem; 2011 Apr; 54(8):2610-26. PubMed ID: 21443205
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Novel meriolin derivatives as rapid apoptosis inducers.
    Drießen D; Stuhldreier F; Frank A; Stark H; Wesselborg S; Stork B; Müller TJJ
    Bioorg Med Chem; 2019 Aug; 27(15):3463-3468. PubMed ID: 31248707
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.