These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

112 related articles for article (PubMed ID: 20961756)

  • 1. 5-(pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists.
    Surman MD; Freeman EE; Grabowski JF; Hadden M; Henderson AJ; Jiang G; Jiang XM; Luche M; Khmelnitsky Y; Vickers S; Viggers J; Cheetham S; Guzzo PR
    Bioorg Med Chem Lett; 2010 Dec; 20(23):7015-9. PubMed ID: 20961756
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones as MCH-1 antagonists for the treatment of obesity.
    Hadden M; Deering DM; Henderson AJ; Surman MD; Luche M; Khmelnitsky Y; Vickers S; Viggers J; Cheetham S; Guzzo PR
    Bioorg Med Chem Lett; 2010 Dec; 20(23):7020-3. PubMed ID: 20951036
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tetrahydrocarboline analogs as MCH-1 antagonists.
    Henderson AJ; Deering D; Grabowski JF; Hadden M; Jiang X; Khmelnitsky Y; Luche M; Surman MD; Cheetham S; Vickers S; Viggers J; Guzzo PR
    Bioorg Med Chem Lett; 2010 Dec; 20(23):7024-8. PubMed ID: 20952195
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.
    Kasai S; Kamata M; Masada S; Kunitomo J; Kamaura M; Okawa T; Takami K; Ogino H; Nakano Y; Ashina S; Watanabe K; Kaisho T; Imai YN; Ryu S; Nakayama M; Nagisa Y; Takekawa S; Kato K; Murata T; Suzuki N; Ishihara Y
    J Med Chem; 2012 May; 55(9):4336-51. PubMed ID: 22490048
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity.
    Judd AS; Souers AJ; Wodka D; Zhao G; Mulhern MM; Iyengar RR; Gao J; Lynch JK; Freeman JC; Falls HD; Brodjian S; Dayton BD; Reilly RM; Gintant G; Limberis JT; Mikhail A; Leitza ST; Houseman KA; Diaz G; Bush EN; Shapiro R; Knourek-Segel V; Hernandez LE; Marsh KC; Sham HL; Collins CA; Kym PR
    Bioorg Med Chem Lett; 2007 Apr; 17(8):2365-71. PubMed ID: 17350253
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity.
    Souers AJ; Gao J; Brune M; Bush E; Wodka D; Vasudevan A; Judd AS; Mulhern M; Brodjian S; Dayton B; Shapiro R; Hernandez LE; Marsh KC; Sham HL; Collins CA; Kym PR
    J Med Chem; 2005 Mar; 48(5):1318-21. PubMed ID: 15743174
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
    Souers AJ; Gao J; Wodka D; Judd AS; Mulhern MM; Napier JJ; Brune ME; Bush EN; Brodjian SJ; Dayton BD; Shapiro R; Hernandez LE; Marsh KC; Sham HL; Collins CA; Kym PR
    Bioorg Med Chem Lett; 2005 Jun; 15(11):2752-7. PubMed ID: 15911251
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists.
    Suzuki T; Kameda M; Ando M; Miyazoe H; Sekino E; Ito S; Masutani K; Kamijo K; Takezawa A; Moriya M; Ito M; Ito J; Nakase K; Matsushita H; Ishihara A; Takenaga N; Tokita S; Kanatani A; Sato N; Fukami T
    Bioorg Med Chem Lett; 2009 Sep; 19(18):5339-45. PubMed ID: 19683441
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.
    Ito M; Ishihara A; Gomori A; Egashira S; Matsushita H; Mashiko S; Ito J; Ito M; Nakase K; Haga Y; Iwaasa H; Suzuki T; Ohtake N; Moriya M; Sato N; MacNeil DJ; Takenaga N; Tokita S; Kanatani A
    Eur J Pharmacol; 2009 Dec; 624(1-3):77-83. PubMed ID: 19836369
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Optimization of 2-piperidin-4-yl-acetamides as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Designing out hERG inhibition.
    Berglund S; Egner BJ; Gradén H; Gradén J; Morgan DG; Inghardt T; Giordanetto F
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4268-73. PubMed ID: 19500979
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.
    Wu WL; Burnett DA; Caplen MA; Domalski MS; Bennett C; Greenlee WJ; Hawes BE; O'Neill K; Weig B; Weston D; Spar B; Kowalski T
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3674-8. PubMed ID: 16690315
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.
    Kasai S; Kamaura M; Kamata M; Aso K; Ogino H; Nakano Y; Watanabe K; Kaisho T; Tawada M; Nagisa Y; Takekawa S; Kato K; Suzuki N; Ishihara Y
    Bioorg Med Chem; 2011 Nov; 19(21):6261-73. PubMed ID: 21975069
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.
    Sasikumar TK; Qiang L; Burnett DA; Greenlee WJ; Hawes BE; Kowalski TJ; O'Neill K; Spar BD; Weig B
    Bioorg Med Chem Lett; 2006 Oct; 16(20):5427-31. PubMed ID: 16889961
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
    Mihalic JT; Chen X; Fan P; Chen X; Fu Y; Liang L; Reed M; Tang L; Chen JL; Jaen J; Li L; Dai K
    Bioorg Med Chem Lett; 2011 Dec; 21(23):7001-5. PubMed ID: 22019296
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Optimization of piperidin-4-yl-urea-containing melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Reducing hERG-associated liabilities.
    Berglund S; Egner BJ; Gradén H; Gradén J; Morgan DG; Inghardt T; Giordanetto F
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4274-9. PubMed ID: 19500982
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists.
    Vasudevan A; Souers AJ; Freeman JC; Verzal MK; Gao J; Mulhern MM; Wodka D; Lynch JK; Engstrom KM; Wagaw SH; Brodjian S; Dayton B; Falls DH; Bush E; Brune M; Shapiro RD; Marsh KC; Hernandez LE; Collins CA; Kym PR
    Bioorg Med Chem Lett; 2005 Dec; 15(23):5293-7. PubMed ID: 16203136
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.
    Souers AJ; Iyengar RR; Judd AS; Beno DW; Gao J; Zhao G; Brune ME; Napier JJ; Mulhern MM; Lynch JK; Freeman JC; Wodka D; Chen CJ; Falls HD; Brodjian S; Dayton BD; Diaz GJ; Bush EN; Shapiro R; Droz BA; Knourek-Segel V; Hernandez LE; Marsh KC; Reilly RM; Sham HL; Collins CA; Kym PR
    Bioorg Med Chem Lett; 2007 Feb; 17(4):884-9. PubMed ID: 17188866
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.
    Yan L; Huo P; Debenham JS; Madsen-Duggan CB; Lao J; Chen RZ; Xiao JC; Shen CP; Stribling DS; Shearman LP; Strack AM; Tsou N; Ball RG; Wang J; Tong X; Bateman TJ; Reddy VB; Fong TM; Hale JJ
    J Med Chem; 2010 May; 53(10):4028-37. PubMed ID: 20423086
    [TBL] [Abstract][Full Text] [Related]  

  • 19. From preclinical to clinical development: the example of a novel treatment for obesity.
    Moore NA; Sargent BJ; Guzzo PR; Surman MD
    Neurobiol Dis; 2014 Jan; 61():47-54. PubMed ID: 23891728
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The discovery and optimization of pyrimidinone-containing MCH R1 antagonists.
    Hertzog DL; Al-Barazanji KA; Bigham EC; Bishop MJ; Britt CS; Carlton DL; Cooper JP; Daniels AJ; Garrido DM; Goetz AS; Grizzle MK; Guo YC; Handlon AL; Ignar DM; Morgan RO; Peat AJ; Tavares FX; Zhou H
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4723-7. PubMed ID: 16870432
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.