These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

284 related articles for article (PubMed ID: 21030680)

  • 1. A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.
    Dbouk HA; Pang H; Fiser A; Backer JM
    Proc Natl Acad Sci U S A; 2010 Nov; 107(46):19897-902. PubMed ID: 21030680
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.
    Wu H; Shekar SC; Flinn RJ; El-Sibai M; Jaiswal BS; Sen KI; Janakiraman V; Seshagiri S; Gerfen GJ; Girvin ME; Backer JM
    Proc Natl Acad Sci U S A; 2009 Dec; 106(48):20258-63. PubMed ID: 19915146
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.
    Zhao JJ; Liu Z; Wang L; Shin E; Loda MF; Roberts TM
    Proc Natl Acad Sci U S A; 2005 Dec; 102(51):18443-8. PubMed ID: 16339315
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.
    Sun M; Hillmann P; Hofmann BT; Hart JR; Vogt PK
    Proc Natl Acad Sci U S A; 2010 Aug; 107(35):15547-52. PubMed ID: 20713702
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.
    Dbouk HA; Khalil BD; Wu H; Shymanets A; Nürnberg B; Backer JM
    PLoS One; 2013; 8(5):e63833. PubMed ID: 23734178
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains.
    Yu J; Wjasow C; Backer JM
    J Biol Chem; 1998 Nov; 273(46):30199-203. PubMed ID: 9804776
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival.
    Kumar A; Redondo-Muñoz J; Perez-García V; Cortes I; Chagoyen M; Carrera AC
    Mol Cell Biol; 2011 May; 31(10):2122-33. PubMed ID: 21383062
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells.
    Yip SC; El-Sibai M; Hill KM; Wu H; Fu Z; Condeelis JS; Backer JM
    Cell Motil Cytoskeleton; 2004 Nov; 59(3):180-8. PubMed ID: 15468162
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins.
    Wang P; Kumar P; Wang C; Defea KA
    Biochem J; 2007 Dec; 408(2):221-30. PubMed ID: 17680774
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
    Guillermet-Guibert J; Bjorklof K; Salpekar A; Gonella C; Ramadani F; Bilancio A; Meek S; Smith AJ; Okkenhaug K; Vanhaesebroeck B
    Proc Natl Acad Sci U S A; 2008 Jun; 105(24):8292-7. PubMed ID: 18544649
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit.
    Shekar SC; Wu H; Fu Z; Yip SC; Nagajyothi ; Cahill SM; Girvin ME; Backer JM
    J Biol Chem; 2005 Jul; 280(30):27850-5. PubMed ID: 15932879
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.
    Miled N; Yan Y; Hon WC; Perisic O; Zvelebil M; Inbar Y; Schneidman-Duhovny D; Wolfson HJ; Backer JM; Williams RL
    Science; 2007 Jul; 317(5835):239-42. PubMed ID: 17626883
    [TBL] [Abstract][Full Text] [Related]  

  • 13. p110beta is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity.
    Asano T; Kanda A; Katagiri H; Nawano M; Ogihara T; Inukai K; Anai M; Fukushima Y; Yazaki Y; Kikuchi M; Hooshmand-Rad R; Heldin CH; Oka Y; Funaki M
    J Biol Chem; 2000 Jun; 275(23):17671-6. PubMed ID: 10748220
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and p85-regulatory subunits with the small GTPase Rab5.
    Kurosu H; Katada T
    J Biochem; 2001 Jul; 130(1):73-8. PubMed ID: 11432782
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).
    Burke JE; Williams RL
    Adv Biol Regul; 2013 Jan; 53(1):97-110. PubMed ID: 23194976
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.
    Zhao L; Vogt PK
    Cell Cycle; 2010 Feb; 9(3):596-600. PubMed ID: 20009532
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase.
    Kang S; Denley A; Vanhaesebroeck B; Vogt PK
    Proc Natl Acad Sci U S A; 2006 Jan; 103(5):1289-94. PubMed ID: 16432180
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases.
    Hon WC; Berndt A; Williams RL
    Oncogene; 2012 Aug; 31(32):3655-66. PubMed ID: 22120714
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Dynamics of GFP-Fusion p110α and p110β Isoforms of PI3K Signaling Pathway in Normal and Cancer Cells.
    Singh P; Dar MS; Singh G; Jamwal G; Sharma PR; Ahmad M; Dar MJ
    J Cell Biochem; 2016 Dec; 117(12):2864-2874. PubMed ID: 27167447
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.
    Geering B; Cutillas PR; Nock G; Gharbi SI; Vanhaesebroeck B
    Proc Natl Acad Sci U S A; 2007 May; 104(19):7809-14. PubMed ID: 17470792
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.