200 related articles for article (PubMed ID: 21033669)
1. Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Wei J; Kitada S; Stebbins JL; Placzek W; Zhai D; Wu B; Rega MF; Zhang Z; Cellitti J; Yang L; Dahl R; Reed JC; Pellecchia M
J Med Chem; 2010 Nov; 53(22):8000-11. PubMed ID: 21033669
[TBL] [Abstract][Full Text] [Related]
2. BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Wei J; Stebbins JL; Kitada S; Dash R; Placzek W; Rega MF; Wu B; Cellitti J; Zhai D; Yang L; Dahl R; Fisher PB; Reed JC; Pellecchia M
J Med Chem; 2010 May; 53(10):4166-76. PubMed ID: 20443627
[TBL] [Abstract][Full Text] [Related]
3. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins.
Wei J; Kitada S; Rega MF; Emdadi A; Yuan H; Cellitti J; Stebbins JL; Zhai D; Sun J; Yang L; Dahl R; Zhang Z; Wu B; Wang S; Reed TA; Wang HG; Lawrence N; Sebti S; Reed JC; Pellecchia M
Mol Cancer Ther; 2009 Apr; 8(4):904-13. PubMed ID: 19372563
[TBL] [Abstract][Full Text] [Related]
4. Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Wei J; Kitada S; Rega MF; Stebbins JL; Zhai D; Cellitti J; Yuan H; Emdadi A; Dahl R; Zhang Z; Yang L; Reed JC; Pellecchia M
J Med Chem; 2009 Jul; 52(14):4511-23. PubMed ID: 19555126
[TBL] [Abstract][Full Text] [Related]
5. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.
Sun Y; Wu J; Aboukameel A; Banerjee S; Arnold AA; Chen J; Nikolovska-Coleska Z; Lin Y; Ling X; Yang D; Wang S; Al-Katib A; Mohammad RM
Cancer Biol Ther; 2008 Sep; 7(9):1418-26. PubMed ID: 18769131
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.
Pan R; Ruvolo VR; Wei J; Konopleva M; Reed JC; Pellecchia M; Andreeff M; Ruvolo PP
Blood; 2015 Jul; 126(3):363-72. PubMed ID: 26045609
[TBL] [Abstract][Full Text] [Related]
7. Preclinical studies of apogossypolone, a novel pan inhibitor of bcl-2 and mcl-1, synergistically potentiates cytotoxic effect of gemcitabine in pancreatic cancer cells.
Banerjee S; Choi M; Aboukameel A; Wang Z; Mohammad M; Chen J; Yang D; Sarkar FH; Mohammad RM
Pancreas; 2010 Apr; 39(3):323-31. PubMed ID: 19823097
[TBL] [Abstract][Full Text] [Related]
8. Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
Enyedy IJ; Ling Y; Nacro K; Tomita Y; Wu X; Cao Y; Guo R; Li B; Zhu X; Huang Y; Long YQ; Roller PP; Yang D; Wang S
J Med Chem; 2001 Dec; 44(25):4313-24. PubMed ID: 11728179
[TBL] [Abstract][Full Text] [Related]
9. A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer.
Yan F; Cao XX; Jiang HX; Zhao XL; Wang JY; Lin YH; Liu QL; Zhang C; Jiang B; Guo F
J Med Chem; 2010 Aug; 53(15):5502-10. PubMed ID: 20684596
[TBL] [Abstract][Full Text] [Related]
10. Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
Wang G; Nikolovska-Coleska Z; Yang CY; Wang R; Tang G; Guo J; Shangary S; Qiu S; Gao W; Yang D; Meagher J; Stuckey J; Krajewski K; Jiang S; Roller PP; Abaan HO; Tomita Y; Wang S
J Med Chem; 2006 Oct; 49(21):6139-42. PubMed ID: 17034116
[TBL] [Abstract][Full Text] [Related]
11. Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.
Meng Y; Tang W; Dai Y; Wu X; Liu M; Ji Q; Ji M; Pienta K; Lawrence T; Xu L
Mol Cancer Ther; 2008 Jul; 7(7):2192-202. PubMed ID: 18645028
[TBL] [Abstract][Full Text] [Related]
12. Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).
Becattini B; Kitada S; Leone M; Monosov E; Chandler S; Zhai D; Kipps TJ; Reed JC; Pellecchia M
Chem Biol; 2004 Mar; 11(3):389-95. PubMed ID: 15123268
[TBL] [Abstract][Full Text] [Related]
13. Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma.
Mi JX; Wang GF; Wang HB; Sun XQ; Ni XY; Zhang XW; Tang JM; Yang DJ
Acta Pharmacol Sin; 2008 Dec; 29(12):1467-77. PubMed ID: 19026166
[TBL] [Abstract][Full Text] [Related]
14. Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model.
Arnold AA; Aboukameel A; Chen J; Yang D; Wang S; Al-Katib A; Mohammad RM
Mol Cancer; 2008 Feb; 7():20. PubMed ID: 18275607
[TBL] [Abstract][Full Text] [Related]
15. Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins.
Tang G; Nikolovska-Coleska Z; Qiu S; Yang CY; Guo J; Wang S
J Med Chem; 2008 Feb; 51(4):717-20. PubMed ID: 18237106
[TBL] [Abstract][Full Text] [Related]
16. An optically pure apogossypolone derivative as potent pan-active inhibitor of anti-apoptotic bcl-2 family proteins.
Wei J; Stebbins JL; Kitada S; Dash R; Zhai D; Placzek WJ; Wu B; Rega MF; Zhang Z; Barile E; Yang L; Dahl R; Fisher PB; Reed JC; Pellecchia M
Front Oncol; 2011; 1():28. PubMed ID: 22655238
[TBL] [Abstract][Full Text] [Related]
17. Anti-tumor compounds identification from gossypol Groebke imidazopyridine product.
Wang W; Lu Y; Chen E; Shen K; Li J
Bioorg Chem; 2021 Sep; 114():105146. PubMed ID: 34328859
[TBL] [Abstract][Full Text] [Related]
18. Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).
Kitada S; Kress CL; Krajewska M; Jia L; Pellecchia M; Reed JC
Blood; 2008 Mar; 111(6):3211-9. PubMed ID: 18202226
[TBL] [Abstract][Full Text] [Related]
19. BH3 mimetics: status of the field and new developments.
Billard C
Mol Cancer Ther; 2013 Sep; 12(9):1691-700. PubMed ID: 23974697
[TBL] [Abstract][Full Text] [Related]
20. Induction of apoptosis and antitumor effects of a small molecule inhibitor of Bcl-2 and Bcl-xl, gossypol acetate, in multiple myeloma in vitro and in vivo.
Lin J; Wu Y; Yang D; Zhao Y
Oncol Rep; 2013 Aug; 30(2):731-8. PubMed ID: 23708869
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
