205 related articles for article (PubMed ID: 21045198)
1. Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.
Yu J; Folmer JJ; Hoesch V; Doherty J; Campbell JB; Burdette D
Drug Metab Dispos; 2011 Feb; 39(2):302-11. PubMed ID: 21045198
[TBL] [Abstract][Full Text] [Related]
2. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
Yan Z; Easterwood LM; Maher N; Torres R; Huebert N; Yost GS
Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
[TBL] [Abstract][Full Text] [Related]
3. In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes.
Kalgutkar AS; Nguyen HT; Vaz AD; Doan A; Dalvie DK; McLeod DG; Murray JC
Drug Metab Dispos; 2003 Oct; 31(10):1240-50. PubMed ID: 12975333
[TBL] [Abstract][Full Text] [Related]
4. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
[TBL] [Abstract][Full Text] [Related]
5. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
[TBL] [Abstract][Full Text] [Related]
6. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
Tang W; Stearns RA; Wang RW; Chiu SH; Baillie TA
Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
[TBL] [Abstract][Full Text] [Related]
7. Substituent effect on the reductive N-dearylation of 3-(indol-1-yl)-1,2-benzisoxazoles by rat liver microsomes.
Tschirret-Guth RA; Wood HB
Drug Metab Dispos; 2003 Aug; 31(8):999-1004. PubMed ID: 12867488
[TBL] [Abstract][Full Text] [Related]
8. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
Teffera Y; Choquette D; Liu J; Colletti AE; Hollis LS; Lin MH; Zhao Z
Chem Res Toxicol; 2010 Nov; 23(11):1743-52. PubMed ID: 20825217
[TBL] [Abstract][Full Text] [Related]
9. In vitro metabolism studies of nomifensine monooxygenation pathways: metabolite identification, reaction phenotyping, and bioactivation mechanism.
Yu J; Brown DG; Burdette D
Drug Metab Dispos; 2010 Oct; 38(10):1767-78. PubMed ID: 20595377
[TBL] [Abstract][Full Text] [Related]
10. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
[TBL] [Abstract][Full Text] [Related]
11. Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
Reddy VB; Karanam BV; Gruber WL; Wallace MA; Vincent SH; Franklin RB; Baillie TA
Chem Res Toxicol; 2005 May; 18(5):880-8. PubMed ID: 15892582
[TBL] [Abstract][Full Text] [Related]
12. Bioactivation of substituted thiophenes including α-chlorothiophene-containing compounds in human liver microsomes.
Chen W; Caceres-Cortes J; Zhang H; Zhang D; Humphreys WG; Gan J
Chem Res Toxicol; 2011 May; 24(5):663-9. PubMed ID: 21417487
[TBL] [Abstract][Full Text] [Related]
13. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
[TBL] [Abstract][Full Text] [Related]
14. Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes.
Yan Z; Zhong HM; Maher N; Torres R; Leo GC; Caldwell GW; Huebert N
Drug Metab Dispos; 2005 Dec; 33(12):1867-76. PubMed ID: 16174805
[TBL] [Abstract][Full Text] [Related]
15. Bioactivation of glafenine by human liver microsomes and peroxidases: identification of electrophilic iminoquinone species and GSH conjugates.
Wen B; Moore DJ
Drug Metab Dispos; 2011 Sep; 39(9):1511-21. PubMed ID: 21628497
[TBL] [Abstract][Full Text] [Related]
16. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
Shen S; Marchick MR; Davis MR; Doss GA; Pohl LR
Chem Res Toxicol; 1999 Feb; 12(2):214-22. PubMed ID: 10027801
[TBL] [Abstract][Full Text] [Related]
17. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
[TBL] [Abstract][Full Text] [Related]
18. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.
Erve JC; Vashishtha SC; DeMaio W; Talaat RE
Drug Metab Dispos; 2007 Jun; 35(6):908-16. PubMed ID: 17353349
[TBL] [Abstract][Full Text] [Related]
19. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
Wen B; Ma L; Zhu M
Chem Biol Interact; 2008 May; 173(1):59-67. PubMed ID: 18359012
[TBL] [Abstract][Full Text] [Related]
20. In vitro metabolic activation of thiabendazole via 5-hydroxythiabendazole: identification of a glutathione conjugate of 5-hydroxythiabendazole.
Dalvie D; Smith E; Deese A; Bowlin S
Drug Metab Dispos; 2006 Apr; 34(4):709-17. PubMed ID: 16434547
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]