BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

308 related articles for article (PubMed ID: 21047555)

  • 1. HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3.
    Chou AH; Chen SY; Yeh TH; Weng YH; Wang HL
    Neurobiol Dis; 2011 Feb; 41(2):481-8. PubMed ID: 21047555
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Polyglutamine-expanded ataxin-3 impairs long-term depression in Purkinje neurons of SCA3 transgenic mouse by inhibiting HAT and impairing histone acetylation.
    Chou AH; Chen YL; Hu SH; Chang YM; Wang HL
    Brain Res; 2014 Oct; 1583():220-9. PubMed ID: 25139423
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.
    Chou AH; Yeh TH; Ouyang P; Chen YL; Chen SY; Wang HL
    Neurobiol Dis; 2008 Jul; 31(1):89-101. PubMed ID: 18502140
    [TBL] [Abstract][Full Text] [Related]  

  • 4. T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse.
    Chou AH; Chen YL; Chiu CC; Yuan SJ; Weng YH; Yeh TH; Lin YL; Fang JM; Wang HL
    Neuropharmacology; 2015 Dec; 99():308-17. PubMed ID: 26254860
    [TBL] [Abstract][Full Text] [Related]  

  • 5. p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons.
    Chou AH; Lin AC; Hong KY; Hu SH; Chen YL; Chen JY; Wang HL
    Neurochem Int; 2011 Feb; 58(2):145-52. PubMed ID: 21092747
    [TBL] [Abstract][Full Text] [Related]  

  • 6. H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse.
    Wang HL; Hu SH; Chou AH; Wang SS; Weng YH; Yeh TH
    Neuropharmacology; 2013 Jul; 70():1-11. PubMed ID: 23347954
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL.
    Chou AH; Yeh TH; Kuo YL; Kao YC; Jou MJ; Hsu CY; Tsai SR; Kakizuka A; Wang HL
    Neurobiol Dis; 2006 Feb; 21(2):333-45. PubMed ID: 16112867
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.
    Switonski PM; Szlachcic WJ; Krzyzosiak WJ; Figiel M
    Neurobiol Dis; 2015 Jan; 73():174-88. PubMed ID: 25301414
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Treatment with sodium butyrate induces autophagy resulting in therapeutic benefits for spinocerebellar ataxia type 3.
    Watchon M; Robinson KJ; Luu L; An Y; Yuan KC; Plenderleith SK; Cheng F; Don EK; Nicholson GA; Lee A; Laird AS
    FASEB J; 2024 Jan; 38(2):e23429. PubMed ID: 38258931
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation.
    Chou AH; Chen CY; Chen SY; Chen WJ; Chen YL; Weng YS; Wang HL
    Neurochem Int; 2010 Jan; 56(2):329-39. PubMed ID: 19909779
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
    Colomer Gould VF; Goti D; Pearce D; Gonzalez GA; Gao H; Bermudez de Leon M; Jenkins NA; Copeland NG; Ross CA; Brown DR
    Neurobiol Dis; 2007 Sep; 27(3):362-9. PubMed ID: 17632007
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
    Hübener J; Weber JJ; Richter C; Honold L; Weiss A; Murad F; Breuer P; Wüllner U; Bellstedt P; Paquet-Durand F; Takano J; Saido TC; Riess O; Nguyen HP
    Hum Mol Genet; 2013 Feb; 22(3):508-18. PubMed ID: 23100324
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Silencing mutant ATXN3 expression resolves molecular phenotypes in SCA3 transgenic mice.
    Rodríguez-Lebrón E; Costa Mdo C; Luna-Cancalon K; Peron TM; Fischer S; Boudreau RL; Davidson BL; Paulson HL
    Mol Ther; 2013 Oct; 21(10):1909-18. PubMed ID: 23820820
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Polyglutamine-induced neurodegeneration in SCA3 is not mitigated by non-expanded ataxin-3: conclusions from double-transgenic mouse models.
    Hübener J; Riess O
    Neurobiol Dis; 2010 Apr; 38(1):116-24. PubMed ID: 20079840
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3.
    Evert BO; Vogt IR; Vieira-Saecker AM; Ozimek L; de Vos RA; Brunt ER; Klockgether T; Wüllner U
    J Neuropathol Exp Neurol; 2003 Oct; 62(10):1006-18. PubMed ID: 14575237
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vivo assessment of riluzole as a potential therapeutic drug for spinocerebellar ataxia type 3.
    Schmidt J; Schmidt T; Golla M; Lehmann L; Weber JJ; Hübener-Schmid J; Riess O
    J Neurochem; 2016 Jul; 138(1):150-62. PubMed ID: 26990650
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3.
    Boy J; Schmidt T; Wolburg H; Mack A; Nuber S; Böttcher M; Schmitt I; Holzmann C; Zimmermann F; Servadio A; Riess O
    Hum Mol Genet; 2009 Nov; 18(22):4282-95. PubMed ID: 19666958
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Divalproex sodium modulates nuclear localization of ataxin-3 and prevents cellular toxicity caused by expanded ataxin-3.
    Wang ZJ; Hanet A; Weishäupl D; Martins IM; Sowa AS; Riess O; Schmidt T
    CNS Neurosci Ther; 2018 May; 24(5):404-411. PubMed ID: 29318784
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4.
    Yi J; Zhang L; Tang B; Han W; Zhou Y; Chen Z; Jia D; Jiang H
    PLoS One; 2013; 8(1):e54792. PubMed ID: 23382971
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells.
    Konno A; Shuvaev AN; Miyake N; Miyake K; Iizuka A; Matsuura S; Huda F; Nakamura K; Yanagi S; Shimada T; Hirai H
    Cerebellum; 2014 Feb; 13(1):29-41. PubMed ID: 23955261
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.