BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

231 related articles for article (PubMed ID: 21055468)

  • 1. MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.
    Durigova M; Nagase H; Mort JS; Roughley PJ
    Matrix Biol; 2011 Mar; 30(2):145-53. PubMed ID: 21055468
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.
    Little CB; Hughes CE; Curtis CL; Janusz MJ; Bohne R; Wang-Weigand S; Taiwo YO; Mitchell PG; Otterness IG; Flannery CR; Caterson B
    Matrix Biol; 2002 Apr; 21(3):271-88. PubMed ID: 12009333
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
    Little CB; Flannery CR; Hughes CE; Mort JS; Roughley PJ; Dent C; Caterson B
    Biochem J; 1999 Nov; 344 Pt 1(Pt 1):61-8. PubMed ID: 10548534
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity.
    Mercuri FA; Maciewicz RA; Tart J; Last K; Fosang AJ
    J Biol Chem; 2000 Oct; 275(42):33038-45. PubMed ID: 11032846
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage.
    Durigova M; Troeberg L; Nagase H; Roughley PJ; Mort JS
    Eur Cell Mater; 2011 Jan; 21():31-45. PubMed ID: 21225593
    [TBL] [Abstract][Full Text] [Related]  

  • 6. MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.
    Struglics A; Hansson M
    Biochem J; 2012 Sep; 446(2):213-23. PubMed ID: 22670872
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
    Tortorella MD; Pratta MA; Fox JW; Arner EC
    J Biol Chem; 1998 Mar; 273(10):5846-50. PubMed ID: 9488721
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13.
    Miwa HE; Gerken TA; Hering TM
    Matrix Biol; 2006 Oct; 25(8):534-45. PubMed ID: 16945513
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.
    Milner JM; Rowan AD; Cawston TE; Young DA
    Arthritis Res Ther; 2006; 8(5):R142. PubMed ID: 16919164
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.
    Durigova M; Soucy P; Fushimi K; Nagase H; Mort JS; Roughley PJ
    Osteoarthritis Cartilage; 2008 Oct; 16(10):1245-52. PubMed ID: 18372197
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.
    Stanton H; Ung L; Fosang AJ
    Biochem J; 2002 May; 364(Pt 1):181-90. PubMed ID: 11988091
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
    Fosang AJ; Neame PJ; Last K; Hardingham TE; Murphy G; Hamilton JA
    J Biol Chem; 1992 Sep; 267(27):19470-4. PubMed ID: 1326552
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair.
    Little CB; Meeker CT; Golub SB; Lawlor KE; Farmer PJ; Smith SM; Fosang AJ
    J Clin Invest; 2007 Jun; 117(6):1627-36. PubMed ID: 17510707
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.
    Lark MW; Williams H; Hoernner LA; Weidner J; Ayala JM; Harper CF; Christen A; Olszewski J; Konteatis Z; Webber R
    Biochem J; 1995 Apr; 307 ( Pt 1)(Pt 1):245-52. PubMed ID: 7717983
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
    Büttner FH; Hughes CE; Margerie D; Lichte A; Tschesche H; Caterson B; Bartnik E
    Biochem J; 1998 Jul; 333 ( Pt 1)(Pt 1):159-65. PubMed ID: 9639575
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4).
    Tortorella MD; Pratta M; Liu RQ; Austin J; Ross OH; Abbaszade I; Burn T; Arner E
    J Biol Chem; 2000 Jun; 275(24):18566-73. PubMed ID: 10751421
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo.
    Sandy JD; Verscharen C
    Biochem J; 2001 Sep; 358(Pt 3):615-26. PubMed ID: 11535123
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Degradation of cartilage aggrecan by collagenase-3 (MMP-13).
    Fosang AJ; Last K; Knäuper V; Murphy G; Neame PJ
    FEBS Lett; 1996 Feb; 380(1-2):17-20. PubMed ID: 8603731
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase.
    Pratta MA; Tortorella MD; Arner EC
    J Biol Chem; 2000 Dec; 275(50):39096-102. PubMed ID: 10991945
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Aggrecanase. A target for the design of inhibitors of cartilage degradation.
    Arner EC; Pratta MA; Decicco CP; Xue CB; Newton RC; Trzaskos JM; Magolda RL; Tortorella MD
    Ann N Y Acad Sci; 1999 Jun; 878():92-107. PubMed ID: 10415722
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.