341 related articles for article (PubMed ID: 21059265)
21. Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor
Andrew RJ; De Rossi P; Nguyen P; Kowalski HR; Recupero AJ; Guerbette T; Krause SV; Rice RC; Laury-Kleintop L; Wagner SL; Thinakaran G
J Biol Chem; 2019 Mar; 294(12):4477-4487. PubMed ID: 30692199
[TBL] [Abstract][Full Text] [Related]
22. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
Kimura A; Hata S; Suzuki T
J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
[TBL] [Abstract][Full Text] [Related]
23. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.
Zhao J; Fu Y; Yasvoina M; Shao P; Hitt B; O'Connor T; Logan S; Maus E; Citron M; Berry R; Binder L; Vassar R
J Neurosci; 2007 Apr; 27(14):3639-49. PubMed ID: 17409228
[TBL] [Abstract][Full Text] [Related]
24. Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice.
Mori T; Koyama N; Yokoo T; Segawa T; Maeda M; Sawmiller D; Tan J; Town T
J Biol Chem; 2020 Nov; 295(48):16251-16266. PubMed ID: 32913125
[TBL] [Abstract][Full Text] [Related]
25. 1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice.
Jeong YJ; Kang GY; Kwon JH; Choi HD; Pack JK; Kim N; Lee YS; Lee HJ
Curr Alzheimer Res; 2015; 12(5):481-92. PubMed ID: 26017559
[TBL] [Abstract][Full Text] [Related]
26. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
Natunen T; Takalo M; Kemppainen S; Leskelä S; Marttinen M; Kurkinen KMA; Pursiheimo JP; Sarajärvi T; Viswanathan J; Gabbouj S; Solje E; Tahvanainen E; Pirttimäki T; Kurki M; Paananen J; Rauramaa T; Miettinen P; Mäkinen P; Leinonen V; Soininen H; Airenne K; Tanzi RE; Tanila H; Haapasalo A; Hiltunen M
Neurobiol Dis; 2016 Jan; 85():187-205. PubMed ID: 26563932
[TBL] [Abstract][Full Text] [Related]
27. The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques.
Kandalepas PC; Sadleir KR; Eimer WA; Zhao J; Nicholson DA; Vassar R
Acta Neuropathol; 2013 Sep; 126(3):329-52. PubMed ID: 23820808
[TBL] [Abstract][Full Text] [Related]
28. Mechanisms that lessen benefits of β-secretase reduction in a mouse model of Alzheimer's disease.
Devi L; Ohno M
Transl Psychiatry; 2013 Jul; 3(7):e284. PubMed ID: 23880880
[TBL] [Abstract][Full Text] [Related]
29. Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression.
Devi L; Tang J; Ohno M
Curr Alzheimer Res; 2015; 12(1):13-21. PubMed ID: 25523425
[TBL] [Abstract][Full Text] [Related]
30. Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development.
Zhang XM; Cai Y; Xiong K; Cai H; Luo XG; Feng JC; Clough RW; Struble RG; Patrylo PR; Yan XX
Eur J Neurosci; 2009 Dec; 30(12):2271-83. PubMed ID: 20092570
[TBL] [Abstract][Full Text] [Related]
31. Ethanol Alters APP Processing and Aggravates Alzheimer-Associated Phenotypes.
Huang D; Yu M; Yang S; Lou D; Zhou W; Zheng L; Wang Z; Cai F; Zhou W; Li T; Song W
Mol Neurobiol; 2018 Jun; 55(6):5006-5018. PubMed ID: 28799137
[TBL] [Abstract][Full Text] [Related]
32. Deletion of the eIF2α Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.
Devi L; Ohno M
PLoS One; 2013; 8(10):e77335. PubMed ID: 24146979
[TBL] [Abstract][Full Text] [Related]
33. SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function.
Gong B; Chen F; Pan Y; Arrieta-Cruz I; Yoshida Y; Haroutunian V; Pasinetti GM
Aging Cell; 2010 Dec; 9(6):1018-31. PubMed ID: 20854419
[TBL] [Abstract][Full Text] [Related]
34. Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases.
Cai Z; Wang C; He W; Chen Y
Curr Alzheimer Res; 2018; 15(11):1045-1052. PubMed ID: 29962345
[TBL] [Abstract][Full Text] [Related]
35. Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
Chiocco MJ; Kulnane LS; Younkin L; Younkin S; Evin G; Lamb BT
J Biol Chem; 2004 Dec; 279(50):52535-42. PubMed ID: 15452128
[TBL] [Abstract][Full Text] [Related]
36. Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep-wake Disturbances in AD Mice.
Yao AY; Halloran PJ; Ge Y; Singh N; Zhou J; Galske J; He W; Yan R; Hu X
J Neurosci; 2023 Aug; 43(35):6197-6211. PubMed ID: 37536983
[TBL] [Abstract][Full Text] [Related]
37. BACE1: the beta-secretase enzyme in Alzheimer's disease.
Vassar R
J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
[TBL] [Abstract][Full Text] [Related]
38. Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.
Chen CH; Zhou W; Liu S; Deng Y; Cai F; Tone M; Tone Y; Tong Y; Song W
Int J Neuropsychopharmacol; 2012 Feb; 15(1):77-90. PubMed ID: 21329555
[TBL] [Abstract][Full Text] [Related]
39. The beta-secretase, BACE: a prime drug target for Alzheimer's disease.
Vassar R
J Mol Neurosci; 2001 Oct; 17(2):157-70. PubMed ID: 11816789
[TBL] [Abstract][Full Text] [Related]
40. PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.
Devi L; Ohno M
Neurobiol Aging; 2014 Oct; 35(10):2272-81. PubMed ID: 24889041
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
