BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 2106831)

  • 1. Tetrahydrohomofolate polyglutamates as inhibitors of thymidylate synthase and glycinamide ribonucleotide formyltransferase in Lactobacillus casei.
    Thorndike J; Kisliuk RL; Gaumont Y; Piper JR; Nair MG
    Arch Biochem Biophys; 1990 Mar; 277(2):334-41. PubMed ID: 2106831
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
    Thorndike J; Gaumont Y; Kisliuk RL; Sirotnak FM; Murthy BR; Nair MG; Piper JR
    Cancer Res; 1989 Jan; 49(1):158-63. PubMed ID: 2521177
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase.
    Nair MG; Murthy BR; Patil SD; Kisliuk RL; Thorndike J; Gaumont Y; Ferone R; Duch DS; Edelstein MP
    J Med Chem; 1989 Jun; 32(6):1277-83. PubMed ID: 2498518
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A; Galivan J; Beardsley GP; Bader H; O'Connor BM; Russello O; Moroson BA; DeYarman MT; Kerwar SS; Freisheim JH
    Cancer Res; 1992 Apr; 52(8):2148-55. PubMed ID: 1313737
    [TBL] [Abstract][Full Text] [Related]  

  • 5. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
    Shih C; Chen VJ; Gossett LS; Gates SB; MacKellar WC; Habeck LL; Shackelford KA; Mendelsohn LG; Soose DJ; Patel VF; Andis SL; Bewley JR; Rayl EA; Moroson BA; Beardsley GP; Kohler W; Ratnam M; Schultz RM
    Cancer Res; 1997 Mar; 57(6):1116-23. PubMed ID: 9067281
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel nonclassical inhibitors of glycinamide ribonucleotide formyltransferase: 10-formyl and 10-hydroxymethyl derivatives of 5,8,10-trideazapteroic acid.
    Liu L; Nair MG; Kisliuk RL
    J Mol Recognit; 1996; 9(2):169-74. PubMed ID: 8877810
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative.
    DeGraw JI; Colwell WT; Brown VH; Sato M; Kisliuk RL; Gaumont Y; Thorndike J; Sirotnak FM
    J Med Chem; 1988 Jan; 31(1):150-3. PubMed ID: 3121855
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase.
    Baldwin SW; Tse A; Gossett LS; Taylor EC; Rosowsky A; Shih C; Moran RG
    Biochemistry; 1991 Feb; 30(7):1997-2006. PubMed ID: 1993209
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.
    Rosowsky A; Forsch RA; Reich VE; Freisheim JH; Moran RG
    J Med Chem; 1992 May; 35(9):1578-88. PubMed ID: 1578484
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase.
    Sanghani SP; Moran RG
    Biochemistry; 1997 Aug; 36(34):10506-16. PubMed ID: 9265631
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of 10-acetyl-5,8-dideazafolic acid: a potent inhibitor of glycinamide ribonucleotide transformylase.
    Caperelli CA; Conigliaro J
    J Med Chem; 1986 Oct; 29(10):2117-9. PubMed ID: 3761327
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol.
    Mendelsohn LG; Shih C; Schultz RM; Worzalla JF
    Invest New Drugs; 1996; 14(3):287-94. PubMed ID: 8958184
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis of 5,11-methenyltetrahydrohomofolate and its antifolate activity in vitro.
    Caperelli CA; Domanico P; Benkovic SJ
    J Med Chem; 1981 Sep; 24(9):1086-8. PubMed ID: 7288824
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibitors of thymidylate synthase and glycinamide ribonucleotide transformylase.
    Jackson RC
    Adv Exp Med Biol; 1994; 370():179-83. PubMed ID: 7660885
    [No Abstract]   [Full Text] [Related]  

  • 15. Deaza analogs of folic acid as antitumor agents.
    Kisliuk RL
    Curr Pharm Des; 2003; 9(31):2615-25. PubMed ID: 14529545
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines.
    Faessel HM; Slocum HK; Rustum YM; Greco WR
    Biochem Pharmacol; 1999 Mar; 57(5):567-77. PubMed ID: 9952321
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
    Piper JR; McCaleb GS; Montgomery JA; Kisliuk RL; Gaumont Y; Thorndike J; Sirotnak FM
    J Med Chem; 1988 Nov; 31(11):2164-9. PubMed ID: 3184124
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of HKSV28 cell growth by 5,11-methenyl-tetrahydrohomofolate.
    Slieker LJ; Benkovic SJ
    Mol Pharmacol; 1984 Mar; 25(2):294-302. PubMed ID: 6700575
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis.
    Tonkinson JL; Marder P; Andis SL; Schultz RM; Gossett LS; Shih C; Mendelsohn LG
    Cancer Chemother Pharmacol; 1997; 39(6):521-31. PubMed ID: 9118464
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: the critical role of polyglutamylation.
    Faessel HM; Slocum HK; Jackson RC; Boritzki TJ; Rustum YM; Nair MG; Greco WR
    Cancer Res; 1998 Jul; 58(14):3036-50. PubMed ID: 9679969
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.