These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

153 related articles for article (PubMed ID: 21070145)

  • 1. Identification of phase-I metabolites and chronic toxicity study of the Kv1.3 blocker PAP-1 (5-(4-phenoxybutoxy)psoralen) in the rat.
    Hao B; Chen ZW; Zhou XJ; Zimin PI; Miljanich GP; Wulff H; Wang YX
    Xenobiotica; 2011 Mar; 41(3):198-211. PubMed ID: 21070145
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3.
    Bodendiek SB; Mahieux C; Hänsel W; Wulff H
    Eur J Med Chem; 2009 May; 44(5):1838-52. PubMed ID: 19056148
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
    Niwa T; Shiraga T; Mitani Y; Terakawa M; Tokuma Y; Kagayama A
    Drug Metab Dispos; 2000 Sep; 28(9):1128-34. PubMed ID: 10950860
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques.
    Pereira LE; Villinger F; Wulff H; Sankaranarayanan A; Raman G; Ansari AA
    Exp Biol Med (Maywood); 2007 Nov; 232(10):1338-54. PubMed ID: 17959847
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potassium channel block by a tripartite complex of two cationophilic ligands and a potassium ion.
    Zimin PI; Garic B; Bodendiek SB; Mahieux C; Wulff H; Zhorov BS
    Mol Pharmacol; 2010 Oct; 78(4):588-99. PubMed ID: 20601455
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metabolism of dl-praeruptorin A in rat liver microsomes using HPLC-electrospray ionization tandem mass spectrometry.
    Ruan H; Zhang Z; Liang XF; Fu Y; Su MQ; Liu QL; Wang XM; Zhu X
    Arch Pharm Res; 2011 Aug; 34(8):1311-21. PubMed ID: 21910053
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Formation in vitro of an inhibitory cytochrome P450 x Fe2+-metabolite complex with roxithromycin and its decladinosyl, O-dealkyl and N-demethyl metabolites in rat liver microsomes.
    Yamazaki H; Shimada T
    Xenobiotica; 1998 Oct; 28(10):995-1004. PubMed ID: 9849646
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases.
    Schmitz A; Sankaranarayanan A; Azam P; Schmidt-Lassen K; Homerick D; Hänsel W; Wulff H
    Mol Pharmacol; 2005 Nov; 68(5):1254-70. PubMed ID: 16099841
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Comparative metabolism of aschantin in human and animal hepatocytes.
    Lee MS; Shim HJ; Cho YY; Lee JY; Kang HC; Song IS; Lee HS
    Arch Pharm Res; 2024 Feb; 47(2):111-126. PubMed ID: 38182943
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
    Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes.
    Tang X; Di X; Zhong Z; Xie Q; Chen Y; Wang F; Ling Z; Xu P; Zhao K; Wang Z; Liu L; Liu X
    J Pharm Biomed Anal; 2016 Sep; 128():98-105. PubMed ID: 27239758
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis.
    Azam P; Sankaranarayanan A; Homerick D; Griffey S; Wulff H
    J Invest Dermatol; 2007 Jun; 127(6):1419-29. PubMed ID: 17273162
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism.
    Wu WN; McKown LA; Reitz AB
    Eur J Drug Metab Pharmacokinet; 2006; 31(4):277-83. PubMed ID: 17315539
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes.
    Zhang Y; Guo X; Lin ET; Benet LZ
    Pharmacology; 1999 Mar; 58(3):147-59. PubMed ID: 9925971
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vitro metabolism of L-696,229, an HIV-1 reverse transcriptase inhibitor in rats and humans. Hepatic and extrahepatic metabolism and identification of enzymes involved in the hepatic metabolism.
    Prueksaritanont T; Dwyer LM; Balani SK; Theoharides AD
    Drug Metab Dispos; 1994; 22(2):281-8. PubMed ID: 7516854
    [TBL] [Abstract][Full Text] [Related]  

  • 16. [Metabolites and metabolic pathways of mesaconitine in rat liver microsomal investigated by using UPLC-MS/MS method in vitro].
    Bi YF; Liu S; Zhang RX; Song FR; Liu ZQ
    Yao Xue Xue Bao; 2013 Dec; 48(12):1823-8. PubMed ID: 24689241
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of rat liver cytochrome P450 3A and 2D in metabolism of imrecoxib.
    Xu HY; Xie ZY; Zhang P; Sun J; Chu FM; Guo ZR; Zhong DF
    Acta Pharmacol Sin; 2006 Mar; 27(3):372-80. PubMed ID: 16490176
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.
    Eagling VA; Tjia JF; Back DJ
    Br J Clin Pharmacol; 1998 Feb; 45(2):107-14. PubMed ID: 9491822
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 5-(3-Phenylpropoxy)psoralen and 5-(4-phenylbutoxy)psoralen: mechanistic studies on phototoxicity.
    Bode CW; Hänsel W
    Pharmazie; 2005 Mar; 60(3):225-8. PubMed ID: 15801679
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effect of the Kv1.3 voltage-gated potassium channel blocker PAP-1 on the initiation and progress of atherosclerosis in a rat model.
    Wu X; Xu R; Cao M; Ruan L; Wang X; Zhang C
    Heart Vessels; 2015 Jan; 30(1):108-14. PubMed ID: 24441938
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.