BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 21077849)

  • 1. Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors.
    Duque G; Vidal C; Rivas D
    Br J Pharmacol; 2011 Mar; 162(5):1109-18. PubMed ID: 21077849
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors.
    Abeles AM; Marjanovic N; Park J; Attur M; Chan ES; Al-Mussawir HE; Dave M; Fisher MC; Stuchin SA; Abramson SB; Pillinger MH
    Arthritis Rheum; 2007 Sep; 56(9):2840-53. PubMed ID: 17763406
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Alendronate enhances osteogenic differentiation of bone marrow stromal cells: a preliminary study.
    Kim HK; Kim JH; Abbas AA; Yoon TR
    Clin Orthop Relat Res; 2009 Dec; 467(12):3121-8. PubMed ID: 18665432
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
    Lobell RB; Omer CA; Abrams MT; Bhimnathwala HG; Brucker MJ; Buser CA; Davide JP; deSolms SJ; Dinsmore CJ; Ellis-Hutchings MS; Kral AM; Liu D; Lumma WC; Machotka SV; Rands E; Williams TM; Graham SL; Hartman GD; Oliff AI; Heimbrook DC; Kohl NE
    Cancer Res; 2001 Dec; 61(24):8758-68. PubMed ID: 11751396
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.
    Coxon FP; Helfrich MH; Van't Hof R; Sebti S; Ralston SH; Hamilton A; Rogers MJ
    J Bone Miner Res; 2000 Aug; 15(8):1467-76. PubMed ID: 10934645
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
    Lerner EC; Zhang TT; Knowles DB; Qian Y; Hamilton AD; Sebti SM
    Oncogene; 1997 Sep; 15(11):1283-8. PubMed ID: 9315095
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone.
    Lau CP; Huang L; Tsui SK; Ng PK; Leung PY; Kumta SM
    J Orthop Res; 2011 Mar; 29(3):403-13. PubMed ID: 20886653
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
    Stark WW; Blaskovich MA; Johnson BA; Qian Y; Vasudevan A; Pitt B; Hamilton AD; Sebti SM; Davies P
    Am J Physiol; 1998 Jul; 275(1):L55-63. PubMed ID: 9688935
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor.
    O'Meara SJ; Kinsella BT
    Biochem J; 2005 Feb; 386(Pt 1):177-89. PubMed ID: 15469414
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines.
    Ageberg M; Rydström K; Lindén O; Linderoth J; Jerkeman M; Drott K
    Exp Cell Res; 2011 May; 317(8):1179-91. PubMed ID: 21324313
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Alendronate promotes bone formation by inhibiting protein prenylation in osteoblasts in rat tooth replantation model.
    Komatsu K; Shimada A; Shibata T; Wada S; Ideno H; Nakashima K; Amizuka N; Noda M; Nifuji A
    J Endocrinol; 2013 Nov; 219(2):145-58. PubMed ID: 24096963
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Investigation of the effect of the farnesyl protein transferase inhibitor R115777 on isoprenylation and intracellular signalling by the prostacyclin receptor.
    O'Meara SJ; Kinsella BT
    Br J Pharmacol; 2004 Sep; 143(2):318-30. PubMed ID: 15339863
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Aminobisphosphonates cause osteoblast apoptosis and inhibit bone nodule formation in vitro.
    Idris AI; Rojas J; Greig IR; Van't Hof RJ; Ralston SH
    Calcif Tissue Int; 2008 Mar; 82(3):191-201. PubMed ID: 18259679
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rho GTPase signaling and PTH 3-34, but not PTH 1-34, maintain the actin cytoskeleton and antagonize bisphosphonate effects in mouse osteoblastic MC3T3-E1 cells.
    Kazmers NH; Ma SA; Yoshida T; Stern PH
    Bone; 2009 Jul; 45(1):52-60. PubMed ID: 19361585
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
    Sun J; Qian Y; Hamilton AD; Sebti SM
    Oncogene; 1998 Mar; 16(11):1467-73. PubMed ID: 9525745
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.
    Finder JD; Litz JL; Blaskovich MA; McGuire TF; Qian Y; Hamilton AD; Davies P; Sebti SM
    J Biol Chem; 1997 May; 272(21):13484-8. PubMed ID: 9153192
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Osteoanabolic effect of alendronate and zoledronate on bone marrow stromal cells (BMSCs) isolated from aged female osteoporotic patients and its implications for their mode of action in the treatment of age-related bone loss.
    Lindtner RA; Tiaden AN; Genelin K; Ebner HL; Manzl C; Klawitter M; Sitte I; von Rechenberg B; Blauth M; Richards PJ
    Osteoporos Int; 2014 Mar; 25(3):1151-61. PubMed ID: 23974861
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor.
    Kusama T; Mukai M; Tatsuta M; Matsumoto Y; Nakamura H; Inoue M
    Clin Exp Metastasis; 2003; 20(6):561-7. PubMed ID: 14598891
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
    Vogt A; Sun J; Qian Y; Hamilton AD; Sebti SM
    J Biol Chem; 1997 Oct; 272(43):27224-9. PubMed ID: 9341167
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase.
    Bergstrom JD; Bostedor RG; Masarachia PJ; Reszka AA; Rodan G
    Arch Biochem Biophys; 2000 Jan; 373(1):231-41. PubMed ID: 10620343
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.