202 related articles for article (PubMed ID: 21078556)
1. Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.
Marcin LR; Higgins MA; Zusi FC; Zhang Y; Dee MF; Parker MF; Muckelbauer JK; Camac DM; Morin PE; Ramamurthy V; Tebben AJ; Lentz KA; Grace JE; Marcinkeviciene JA; Kopcho LM; Burton CR; Barten DM; Toyn JH; Meredith JE; Albright CF; Bronson JJ; Macor JE; Thompson LA
Bioorg Med Chem Lett; 2011 Jan; 21(1):537-41. PubMed ID: 21078556
[TBL] [Abstract][Full Text] [Related]
2. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Probst GD; Bowers S; Sealy JM; Stupi B; Dressen D; Jagodzinska BM; Aquino J; Gailunas A; Truong AP; Tso L; Xu YZ; Hom RK; John V; Tung JS; Pleiss MA; Tucker JA; Konradi AW; Sham HL; Jagodzinski J; Toth G; Brecht E; Yao N; Pan H; Lin M; Artis DR; Ruslim L; Bova MP; Sinha S; Yednock TA; Gauby S; Zmolek W; Quinn KP; Sauer JM
Bioorg Med Chem Lett; 2010 Oct; 20(20):6034-9. PubMed ID: 20822903
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Lindsley SR; Moore KP; Rajapakse HA; Selnick HG; Young MB; Zhu H; Munshi S; Kuo L; McGaughey GB; Colussi D; Crouthamel MC; Lai MT; Pietrak B; Price EA; Sankaranarayanan S; Simon AJ; Seabrook GR; Hazuda DJ; Pudvah NT; Hochman JH; Graham SL; Vacca JP; Nantermet PG
Bioorg Med Chem Lett; 2007 Jul; 17(14):4057-61. PubMed ID: 17482814
[TBL] [Abstract][Full Text] [Related]
4. Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.
Truong AP; Probst GD; Aquino J; Fang L; Brogley L; Sealy JM; Hom RK; Tucker JA; John V; Tung JS; Pleiss MA; Konradi AW; Sham HL; Dappen MS; Tóth G; Yao N; Brecht E; Pan H; Artis DR; Ruslim L; Bova MP; Sinha S; Yednock TA; Zmolek W; Quinn KP; Sauer JM
Bioorg Med Chem Lett; 2010 Aug; 20(16):4789-94. PubMed ID: 20634069
[TBL] [Abstract][Full Text] [Related]
5. Potent pyrrolidine- and piperidine-based BACE-1 inhibitors.
Iserloh U; Wu Y; Cumming JN; Pan J; Wang LY; Stamford AW; Kennedy ME; Kuvelkar R; Chen X; Parker EM; Strickland C; Voigt J
Bioorg Med Chem Lett; 2008 Jan; 18(1):414-7. PubMed ID: 18023580
[TBL] [Abstract][Full Text] [Related]
6. Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.
Sealy JM; Truong AP; Tso L; Probst GD; Aquino J; Hom RK; Jagodzinska BM; Dressen D; Wone DW; Brogley L; John V; Tung JS; Pleiss MA; Tucker JA; Konradi AW; Dappen MS; Toth G; Pan H; Ruslim L; Miller J; Bova MP; Sinha S; Quinn KP; Sauer JM
Bioorg Med Chem Lett; 2009 Nov; 19(22):6386-91. PubMed ID: 19811916
[TBL] [Abstract][Full Text] [Related]
7. Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads.
Huang Y; Strobel ED; Ho CY; Reynolds CH; Conway KA; Piesvaux JA; Brenneman DE; Yohrling GJ; Moore Arnold H; Rosenthal D; Alexander RS; Tounge BA; Mercken M; Vandermeeren M; Parker MH; Reitz AB; Baxter EW
Bioorg Med Chem Lett; 2010 May; 20(10):3158-60. PubMed ID: 20399652
[TBL] [Abstract][Full Text] [Related]
8. Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.
Machauer R; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Neumann U; Paganetti P
Bioorg Med Chem Lett; 2009 Mar; 19(5):1361-5. PubMed ID: 19195886
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues.
Bäck M; Nyhlén J; Kvarnström I; Appelgren S; Borkakoti N; Jansson K; Lindberg J; Nyström S; Hallberg A; Rosenquist S; Samuelsson B
Bioorg Med Chem; 2008 Nov; 16(21):9471-86. PubMed ID: 18842420
[TBL] [Abstract][Full Text] [Related]
10. BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Clarke B; Cutler L; Demont E; Dingwall C; Dunsdon R; Hawkins J; Howes C; Hussain I; Maile G; Matico R; Mosley J; Naylor A; O'Brien A; Redshaw S; Rowland P; Soleil V; Smith KJ; Sweitzer S; Theobald P; Vesey D; Walter DS; Wayne G
Bioorg Med Chem Lett; 2010 Aug; 20(15):4639-44. PubMed ID: 20579874
[TBL] [Abstract][Full Text] [Related]
11. Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor.
Iserloh U; Pan J; Stamford AW; Kennedy ME; Zhang Q; Zhang L; Parker EM; McHugh NA; Favreau L; Strickland C; Voigt J
Bioorg Med Chem Lett; 2008 Jan; 18(1):418-22. PubMed ID: 17980584
[TBL] [Abstract][Full Text] [Related]
12. Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic.
Wångsell F; Russo F; Sävmarker J; Rosenquist A; Samuelsson B; Larhed M
Bioorg Med Chem Lett; 2009 Aug; 19(16):4711-4. PubMed ID: 19576765
[TBL] [Abstract][Full Text] [Related]
13. BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Clarke B; Demont E; Dingwall C; Dunsdon R; Faller A; Hawkins J; Hussain I; MacPherson D; Maile G; Matico R; Milner P; Mosley J; Naylor A; O'Brien A; Redshaw S; Riddell D; Rowland P; Soleil V; Smith KJ; Stanway S; Stemp G; Sweitzer S; Theobald P; Vesey D; Walter DS; Ward J; Wayne G
Bioorg Med Chem Lett; 2008 Feb; 18(3):1017-21. PubMed ID: 18166458
[TBL] [Abstract][Full Text] [Related]
14. Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.
Rueeger H; Rondeau JM; McCarthy C; Möbitz H; Tintelnot-Blomley M; Neumann U; Desrayaud S
Bioorg Med Chem Lett; 2011 Apr; 21(7):1942-7. PubMed ID: 21388807
[TBL] [Abstract][Full Text] [Related]
15. Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
Lerchner A; Machauer R; Betschart C; Veenstra S; Rueeger H; McCarthy C; Tintelnot-Blomley M; Jaton AL; Rabe S; Desrayaud S; Enz A; Staufenbiel M; Paganetti P; Rondeau JM; Neumann U
Bioorg Med Chem Lett; 2010 Jan; 20(2):603-7. PubMed ID: 19963375
[TBL] [Abstract][Full Text] [Related]
16. Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing.
Nantermet PG; Rajapakse HA; Stanton MG; Stauffer SR; Barrow JC; Gregro AR; Moore KP; Steinbeiser MA; Swestock J; Selnick HG; Graham SL; McGaughey GB; Colussi D; Lai MT; Sankaranarayanan S; Simon AJ; Munshi S; Cook JJ; Holahan MA; Michener MS; Vacca JP
ChemMedChem; 2009 Jan; 4(1):37-40. PubMed ID: 19085994
[No Abstract] [Full Text] [Related]
17. Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.
Barrow JC; Rittle KE; Ngo PL; Selnick HG; Graham SL; Pitzenberger SM; McGaughey GB; Colussi D; Lai MT; Huang Q; Tugusheva K; Espeseth AS; Simon AJ; Munshi SK; Vacca JP
ChemMedChem; 2007 Jul; 2(7):995-9. PubMed ID: 17458843
[No Abstract] [Full Text] [Related]
18. Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE.
Wu YJ; Zhang Y; Good AC; Burton CR; Toyn JH; Albright CF; Macor JE; Thompson LA
Bioorg Med Chem Lett; 2009 May; 19(10):2654-60. PubMed ID: 19375914
[TBL] [Abstract][Full Text] [Related]
19. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
Machauer R; Laumen K; Veenstra S; Rondeau JM; Tintelnot-Blomley M; Betschart C; Jaton AL; Desrayaud S; Staufenbiel M; Rabe S; Paganetti P; Neumann U
Bioorg Med Chem Lett; 2009 Mar; 19(5):1366-70. PubMed ID: 19195887
[TBL] [Abstract][Full Text] [Related]
20. Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bowers S; Xu YZ; Yuan S; Probst GD; Hom RK; Chan W; Konradi AW; Sham HL; Zhu YL; Beroza P; Pan H; Brecht E; Yao N; Lougheed J; Tam D; Ren Z; Ruslim L; Bova MP; Artis DR
Bioorg Med Chem Lett; 2013 Apr; 23(7):2181-6. PubMed ID: 23465612
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
