79 related articles for article (PubMed ID: 21082722)
1. New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors.
Büchold C; Hemberger Y; Heindl C; Welker A; Degel B; Pfeuffer T; Staib P; Schneider S; Rosenthal PJ; Gut J; Morschhäuser J; Bringmann G; Schirmeister T
ChemMedChem; 2011 Jan; 6(1):141-52. PubMed ID: 21082722
[TBL] [Abstract][Full Text] [Related]
2. Cis-Configured aziridines are new pseudo-irreversible dual-mode inhibitors of Candida albicans secreted aspartic protease 2.
Degel B; Staib P; Rohrer S; Scheiber J; Martina E; Büchold C; Baumann K; Morschhäuser J; Schirmeister T
ChemMedChem; 2008 Feb; 3(2):302-15. PubMed ID: 18038380
[TBL] [Abstract][Full Text] [Related]
3. New peptidic cysteine protease inhibitors derived from the electrophilic alpha-amino acid aziridine-2,3-dicarboxylic acid.
Schirmeister T
J Med Chem; 1999 Feb; 42(4):560-72. PubMed ID: 10052963
[TBL] [Abstract][Full Text] [Related]
4. Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
Devadas B; Freeman SK; Zupec ME; Lu HF; Nagarajan SR; Kishore NS; Lodge JK; Kuneman DW; McWherter CA; Vinjamoori DV; Getman DP; Gordon JI; Sikorski JA
J Med Chem; 1997 Aug; 40(16):2609-25. PubMed ID: 9258368
[TBL] [Abstract][Full Text] [Related]
5. Rational design of aziridine-containing cysteine protease inhibitors with improved potency: studies on inhibition mechanism.
Vicik R; Helten H; Schirmeister T; Engels B
ChemMedChem; 2006 Sep; 1(9):1021-8. PubMed ID: 16933238
[TBL] [Abstract][Full Text] [Related]
6. The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase.
Diaper CM; Sutherland A; Pillai B; James MN; Semchuk P; Blanchard JS; Vederas JC
Org Biomol Chem; 2005 Dec; 3(24):4402-11. PubMed ID: 16327902
[TBL] [Abstract][Full Text] [Related]
7. Applying small molecule microarrays and resulting affinity probe cocktails for proteome profiling of mammalian cell lysates.
Shi H; Uttamchandani M; Yao SQ
Chem Asian J; 2011 Oct; 6(10):2803-15. PubMed ID: 21898842
[TBL] [Abstract][Full Text] [Related]
8. Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors.
Caffrey CR; Placha L; Barinka C; Hradilek M; Dostál J; Sajid M; McKerrow JH; Majer P; Konvalinka J; Vondrásek J
Biol Chem; 2005 Apr; 386(4):339-49. PubMed ID: 15899696
[TBL] [Abstract][Full Text] [Related]
9. Hydroxyethylene sulfones as a new scaffold to address aspartic proteases: design, synthesis, and structural characterization.
Specker E; Böttcher J; Heine A; Sotriffer CA; Lilie H; Schoop A; Müller G; Griebenow N; Klebe G
J Med Chem; 2005 Oct; 48(21):6607-19. PubMed ID: 16220977
[TBL] [Abstract][Full Text] [Related]
10. Molecular basis for the stereoselective ammoniolysis of N-alkyl aziridine-2-carboxylates catalyzed by Candida antarctica lipase B.
Park JH; Ha HJ; Lee WK; Généreux-Vincent T; Kazlauskas RJ
Chembiochem; 2009 Sep; 10(13):2213-22. PubMed ID: 19672908
[TBL] [Abstract][Full Text] [Related]
11. Kinetic resolution of tert-butyl (RS)-3-alkylcyclopentene-1-carboxylates for the synthesis of homochiral 3-alkyl-cispentacin and 3-alkyl-transpentacin derivatives.
Bunnage ME; Davies SG; Parkin RM; Roberts PM; Smith AD; Withey JM
Org Biomol Chem; 2004 Nov; 2(22):3337-54. PubMed ID: 15534712
[TBL] [Abstract][Full Text] [Related]
12. Lipase-catalyzed resolution of (2R*,3S*)- and (2R*,3R*)-3-methyl-3-phenyl-2-aziridinemethanol at low temperatures and determination of the absolute configurations of the four stereoisomers.
Sakai T; Liu Y; Ohta H; Korenaga T; Ema T
J Org Chem; 2005 Feb; 70(4):1369-75. PubMed ID: 15704972
[TBL] [Abstract][Full Text] [Related]
13. High kinetic resolution in the addition of a racemic allenylzinc onto enantiopure N-tert-butanesulfinimines: concise synthesis of enantiopure trans-2-ethynylaziridines.
Chemla F; Ferreira F
J Org Chem; 2004 Nov; 69(24):8244-50. PubMed ID: 15549794
[TBL] [Abstract][Full Text] [Related]
14. Solvent- and temperature-dependent functionalisation of enantioenriched aziridines.
de Ceglie MC; Musio B; Affortunato F; Moliterni A; Altomare A; Florio S; Luisi R
Chemistry; 2011 Jan; 17(1):286-96. PubMed ID: 21207624
[TBL] [Abstract][Full Text] [Related]
15. The potential of P1 site alterations in peptidomimetic protease inhibitors as suggested by virtual screening and explored by the use of C-C-coupling reagents.
Weik S; Luksch T; Evers A; Böttcher J; Sotriffer CA; Hasilik A; Löffler HG; Klebe G; Rademann J
ChemMedChem; 2006 Apr; 1(4):445-57. PubMed ID: 16892380
[TBL] [Abstract][Full Text] [Related]
16. Flexibility of liver alcohol dehydrogenase in stereoselective binding of 3-butylthiolane 1-oxides.
Cho H; Ramaswamy S; Plapp BV
Biochemistry; 1997 Jan; 36(2):382-9. PubMed ID: 9003191
[TBL] [Abstract][Full Text] [Related]
17. Inhibition of cysteine proteases by peptides containing aziridine-2,3-dicarboxylic acid building blocks.
Schirmeister T
Biopolymers; 1999; 51(1):87-97. PubMed ID: 10380356
[TBL] [Abstract][Full Text] [Related]
18. Aminoalkylaziridines as substrates and inhibitors of lysyl oxidase: specific inactivation of the enzyme by N-(5-aminopentyl)aziridine.
Nagan N; Callery PS; Kagan HM
Front Biosci; 1998 May; 3():A23-6. PubMed ID: 9563974
[TBL] [Abstract][Full Text] [Related]
19. Rational design of improved aziridine-based inhibitors of cysteine proteases.
Buback V; Mladenovic M; Engels B; Schirmeister T
J Phys Chem B; 2009 Apr; 113(15):5282-9. PubMed ID: 19301885
[TBL] [Abstract][Full Text] [Related]
20. Atomistic insights into the inhibition of cysteine proteases: first QM/MM calculations clarifying the stereoselectivity of epoxide-based inhibitors.
Mladenovic M; Ansorg K; Fink RF; Thiel W; Schirmeister T; Engels B
J Phys Chem B; 2008 Sep; 112(37):11798-808. PubMed ID: 18712902
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
