BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

374 related articles for article (PubMed ID: 21087194)

  • 1. Selection of behaviors and segmental coordination during larval locomotion is disrupted by nuclear polyglutamine inclusions in a new Drosophila Huntington's disease-like model.
    Nishimura Y; Yalgin C; Akimoto S; Doumanis J; Sasajima R; Nukina N; Miyakawa H; Moore AW; Morimoto T
    J Neurogenet; 2010 Dec; 24(4):194-206. PubMed ID: 21087194
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.
    Lee WC; Yoshihara M; Littleton JT
    Proc Natl Acad Sci U S A; 2004 Mar; 101(9):3224-9. PubMed ID: 14978262
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.
    Dong X; Zong S; Witting A; Lindenberg KS; Kochanek S; Huang B
    J Gene Med; 2012 Jul; 14(7):468-81. PubMed ID: 22700462
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.
    Schilling G; Savonenko AV; Klevytska A; Morton JL; Tucker SM; Poirier M; Gale A; Chan N; Gonzales V; Slunt HH; Coonfield ML; Jenkins NA; Copeland NG; Ross CA; Borchelt DR
    Hum Mol Genet; 2004 Aug; 13(15):1599-610. PubMed ID: 15190011
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
    Tanaka Y; Igarashi S; Nakamura M; Gafni J; Torcassi C; Schilling G; Crippen D; Wood JD; Sawa A; Jenkins NA; Copeland NG; Borchelt DR; Ross CA; Ellerby LM
    Neurobiol Dis; 2006 Feb; 21(2):381-91. PubMed ID: 16150600
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Live axonal transport disruption by mutant huntingtin fragments in Drosophila motor neuron axons.
    Sinadinos C; Burbidge-King T; Soh D; Thompson LM; Marsh JL; Wyttenbach A; Mudher AK
    Neurobiol Dis; 2009 May; 34(2):389-95. PubMed ID: 19268537
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model.
    Weiss KR; Kimura Y; Lee WC; Littleton JT
    Genetics; 2012 Feb; 190(2):581-600. PubMed ID: 22095086
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.
    Jackson GR; Salecker I; Dong X; Yao X; Arnheim N; Faber PW; MacDonald ME; Zipursky SL
    Neuron; 1998 Sep; 21(3):633-42. PubMed ID: 9768849
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.
    Wang YL; Liu W; Wada E; Murata M; Wada K; Kanazawa I
    Neurosci Res; 2005 Nov; 53(3):241-9. PubMed ID: 16095740
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases.
    de Pril R; Fischer DF; Roos RA; van Leeuwen FW
    Mol Cell Neurosci; 2007 Jan; 34(1):10-9. PubMed ID: 17092742
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis.
    Miller J; Arrasate M; Shaby BA; Mitra S; Masliah E; Finkbeiner S
    J Neurosci; 2010 Aug; 30(31):10541-50. PubMed ID: 20685997
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.
    Arrasate M; Mitra S; Schweitzer ES; Segal MR; Finkbeiner S
    Nature; 2004 Oct; 431(7010):805-10. PubMed ID: 15483602
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.
    Bates EA; Victor M; Jones AK; Shi Y; Hart AC
    J Neurosci; 2006 Mar; 26(10):2830-8. PubMed ID: 16525063
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.
    Steffan JS; Bodai L; Pallos J; Poelman M; McCampbell A; Apostol BL; Kazantsev A; Schmidt E; Zhu YZ; Greenwald M; Kurokawa R; Housman DE; Jackson GR; Marsh JL; Thompson LM
    Nature; 2001 Oct; 413(6857):739-43. PubMed ID: 11607033
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.
    Valencia A; Reeves PB; Sapp E; Li X; Alexander J; Kegel KB; Chase K; Aronin N; DiFiglia M
    J Neurosci Res; 2010 Jan; 88(1):179-90. PubMed ID: 19642201
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila.
    Gunawardena S; Her LS; Brusch RG; Laymon RA; Niesman IR; Gordesky-Gold B; Sintasath L; Bonini NM; Goldstein LS
    Neuron; 2003 Sep; 40(1):25-40. PubMed ID: 14527431
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cellular and subcellular localization of Huntingtin [corrected] aggregates in the brain of a rat transgenic for Huntington disease.
    Petrasch-Parwez E; Nguyen HP; Löbbecke-Schumacher M; Habbes HW; Wieczorek S; Riess O; Andres KH; Dermietzel R; Von Hörsten S
    J Comp Neurol; 2007 Apr; 501(5):716-30. PubMed ID: 17299753
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.
    Huang B; Schiefer J; Sass C; Kosinski CM; Kochanek S
    J Gene Med; 2008 Mar; 10(3):269-79. PubMed ID: 18067195
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.
    Sang TK; Li C; Liu W; Rodriguez A; Abrams JM; Zipursky SL; Jackson GR
    Hum Mol Genet; 2005 Feb; 14(3):357-72. PubMed ID: 15590702
    [TBL] [Abstract][Full Text] [Related]  

  • 20. SUMO modification of Huntingtin and Huntington's disease pathology.
    Steffan JS; Agrawal N; Pallos J; Rockabrand E; Trotman LC; Slepko N; Illes K; Lukacsovich T; Zhu YZ; Cattaneo E; Pandolfi PP; Thompson LM; Marsh JL
    Science; 2004 Apr; 304(5667):100-4. PubMed ID: 15064418
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.