BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 21087861)

  • 1. Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.
    Fader LD; Bethell R; Bonneau P; Bös M; Bousquet Y; Cordingley MG; Coulombe R; Deroy P; Faucher AM; Gagnon A; Goudreau N; Grand-Maître C; Guse I; Hucke O; Kawai SH; Lacoste JE; Landry S; Lemke CT; Malenfant E; Mason S; Morin S; O'Meara J; Simoneau B; Titolo S; Yoakim C
    Bioorg Med Chem Lett; 2011 Jan; 21(1):398-404. PubMed ID: 21087861
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.
    Fader LD; Landry S; Goulet S; Morin S; Kawai SH; Bousquet Y; Dion I; Hucke O; Goudreau N; Lemke CT; Rancourt J; Bonneau P; Titolo S; Amad M; Garneau M; Duan J; Mason S; Simoneau B
    Bioorg Med Chem Lett; 2013 Jun; 23(11):3401-5. PubMed ID: 23601710
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.
    Fader LD; Landry S; Morin S; Kawai SH; Bousquet Y; Hucke O; Goudreau N; Lemke CT; Bonneau P; Titolo S; Mason S; Simoneau B
    Bioorg Med Chem Lett; 2013 Jun; 23(11):3396-400. PubMed ID: 23583513
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pyrazole NNRTIs 1: design and initial optimisation of a novel template.
    Mowbray CE; Burt C; Corbau R; Perros M; Tran I; Stupple PA; Webster R; Wood A
    Bioorg Med Chem Lett; 2009 Oct; 19(19):5599-602. PubMed ID: 19709880
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and biological evaluation of N4-(hetero)arylsulfonylquinoxalinones as HIV-1 reverse transcriptase inhibitors.
    Xu B; Sun Y; Guo Y; Cao Y; Yu T
    Bioorg Med Chem; 2009 Apr; 17(7):2767-74. PubMed ID: 19269831
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.
    Sweeney ZK; Harris SF; Arora SF; Javanbakht H; Li Y; Fretland J; Davidson JP; Billedeau JR; Gleason SK; Hirschfeld D; Kennedy-Smith JJ; Mirzadegan T; Roetz R; Smith M; Sperry S; Suh JM; Wu J; Tsing S; Villaseñor AG; Paul A; Su G; Heilek G; Hang JQ; Zhou AS; Jernelius JA; Zhang FJ; Klumpp K
    J Med Chem; 2008 Dec; 51(23):7449-58. PubMed ID: 19007201
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity.
    Heeres J; de Jonge MR; Koymans LM; Daeyaert FF; Vinkers M; Van Aken KJ; Arnold E; Das K; Kilonda A; Hoornaert GJ; Compernolle F; Cegla M; Azzam RA; Andries K; de Béthune MP; Azijn H; Pauwels R; Lewi PJ; Janssen PA
    J Med Chem; 2005 Mar; 48(6):1910-8. PubMed ID: 15771435
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.
    Wu B; Kuhen K; Ngoc Nguyen T; Ellis D; Anaclerio B; He X; Yang K; Karanewsky D; Yin H; Wolff K; Bieza K; Caldwell J; He Y
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3430-3. PubMed ID: 16632349
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis.
    Kirschberg TA; Balakrishnan M; Huang W; Hluhanich R; Kutty N; Liclican AC; McColl DJ; Squires NH; Lansdon EB
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1131-4. PubMed ID: 18083512
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies.
    Zhan P; Liu X; Li Z; Fang Z; Li Z; Wang D; Pannecouque C; Clercq ED
    Bioorg Med Chem; 2009 Aug; 17(16):5920-7. PubMed ID: 19620009
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Strategies for the design of HIV-1 non-nucleoside reverse transcriptase inhibitors: lessons from the development of seven representative paradigms.
    Li D; Zhan P; De Clercq E; Liu X
    J Med Chem; 2012 Apr; 55(8):3595-613. PubMed ID: 22268494
    [No Abstract]   [Full Text] [Related]  

  • 12. Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.
    Su DS; Lim JJ; Tinney E; Wan BL; Young MB; Anderson KD; Rudd D; Munshi V; Bahnck C; Felock PJ; Lu M; Lai MT; Touch S; Moyer G; Distefano DJ; Flynn JA; Liang Y; Sanchez R; Prasad S; Yan Y; Perlow-Poehnelt R; Torrent M; Miller M; Vacca JP; Williams TM; Anthony NJ
    Bioorg Med Chem Lett; 2009 Sep; 19(17):5119-23. PubMed ID: 19631528
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain.
    Xiong YZ; Chen FE; Balzarini J; De Clercq E; Pannecouque C
    Chem Biodivers; 2009 Apr; 6(4):561-8. PubMed ID: 19353537
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs.
    Gu SX; Yang SQ; He QQ; Ma XD; Chen FE; Dai HF; Clercq ED; Balzarini J; Pannecouque C
    Bioorg Med Chem; 2011 Dec; 19(23):7093-9. PubMed ID: 22037050
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT inhibitors.
    Rawal RK; Prabhakar YS; Katti SB; De Clercq E
    Bioorg Med Chem; 2005 Dec; 13(24):6771-6. PubMed ID: 16198576
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-based design, parallel synthesis, structure-activity relationship, and molecular modeling studies of thiocarbamates, new potent non-nucleoside HIV-1 reverse transcriptase inhibitor isosteres of phenethylthiazolylthiourea derivatives.
    Ranise A; Spallarossa A; Cesarini S; Bondavalli F; Schenone S; Bruno O; Menozzi G; Fossa P; Mosti L; La Colla M; Sanna G; Murreddu M; Collu G; Busonera B; Marongiu ME; Pani A; La Colla P; Loddo R
    J Med Chem; 2005 Jun; 48(11):3858-73. PubMed ID: 15916438
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents.
    Monforte AM; Logoteta P; Ferro S; De Luca L; Iraci N; Maga G; Clercq ED; Pannecouque C; Chimirri A
    Bioorg Med Chem; 2009 Aug; 17(16):5962-7. PubMed ID: 19616956
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.
    Su DS; Lim JJ; Tinney E; Tucker TJ; Saggar S; Sisko JT; Wan BL; Young MB; Anderson KD; Rudd D; Munshi V; Bahnck C; Felock PJ; Lu M; Lai MT; Touch S; Moyer G; Distefano DJ; Flynn JA; Liang Y; Sanchez R; Perlow-Poehnelt R; Miller M; Vacca JP; Williams TM; Anthony NJ
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4328-32. PubMed ID: 20609585
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pharmacophore and structure-activity relationships of integrase inhibition within a dual inhibitor scaffold of HIV reverse transcriptase and integrase.
    Wang Z; Tang J; Salomon CE; Dreis CD; Vince R
    Bioorg Med Chem; 2010 Jun; 18(12):4202-11. PubMed ID: 20576573
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and studies of new 2-(coumarin-4-yloxy)-4,6-(substituted)-S-triazine derivatives as potential anti-HIV agents.
    Mahajan DH; Pannecouque C; De Clercq E; Chikhalia KH
    Arch Pharm (Weinheim); 2009 May; 342(5):281-90. PubMed ID: 19415671
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.