BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 21090809)

  • 1. Design, synthesis, and evaluation of dibenzo[c,h][1,6]naphthyridines as topoisomerase I inhibitors and potential anticancer agents.
    Kiselev E; Dexheimer TS; Pommier Y; Cushman M
    J Med Chem; 2010 Dec; 53(24):8716-26. PubMed ID: 21090809
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dibenzo[c,h][1,5]naphthyridinediones as topoisomerase I inhibitors: design, synthesis, and biological evaluation.
    Kiselev E; Empey N; Agama K; Pommier Y; Cushman M
    J Org Chem; 2012 Jun; 77(11):5167-72. PubMed ID: 22587603
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity.
    Alonso C; Fuertes M; González M; Rubiales G; Tesauro C; Knudsen BR; Palacios F
    Eur J Med Chem; 2016 Jun; 115():179-90. PubMed ID: 27017547
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and biological evaluation of 1,5-naphthyridines as topoisomerase I inhibitors. A new family of antiproliferative agents.
    Alonso C; Fuertes M; González M; Rodríguez-Gascón A; Rubiales G; Palacios F
    Curr Top Med Chem; 2014; 14(23):2722-8. PubMed ID: 25515747
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: In vitro screening, molecular docking and ADME predictions.
    Kardile RA; Sarkate AP; Borude AS; Mane RS; Lokwani DK; Tiwari SV; Azad R; Burra PVLS; Thopate SR
    Bioorg Chem; 2021 Oct; 115():105174. PubMed ID: 34314913
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and biological evaluations of novel indenoisoquinolines as topoisomerase I inhibitors.
    Zhang X; Wang R; Zhao L; Lu N; Wang J; You Q; Li Z; Guo Q
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1276-81. PubMed ID: 22079759
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Straightforward synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents of hybrid Chromeno[4,3-b][1,5]Naphthyridines and Chromeno[4,3-b][1,5]Naphthyridin-6-ones.
    Martín-Encinas E; Rubiales G; Knudssen BR; Palacios F; Alonso C
    Eur J Med Chem; 2019 Sep; 178():752-766. PubMed ID: 31229877
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Fused chromeno and quinolino[1,8]naphthyridines: Synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents.
    Martín-Encinas E; Rubiales G; Knudsen BR; Palacios F; Alonso C
    Bioorg Med Chem; 2021 Jun; 40():116177. PubMed ID: 33962152
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity.
    Elbadawi MM; Eldehna WM; Wang W; Agama KK; Pommier Y; Abe M
    Eur J Med Chem; 2021 Apr; 215():113261. PubMed ID: 33631697
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents: a systematic study of structure-activity relationships.
    Kiselev E; Agama K; Pommier Y; Cushman M
    J Med Chem; 2012 Feb; 55(4):1682-97. PubMed ID: 22329436
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/IIα inhibitors.
    Arepalli SK; Lee C; Sim S; Lee K; Jo H; Jun KY; Kwon Y; Kang JS; Jung JK; Lee H
    Bioorg Med Chem; 2018 Oct; 26(18):5181-5193. PubMed ID: 30253887
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity.
    Majumdar P; Bathula C; Basu SM; Das SK; Agarwal R; Hati S; Singh A; Sen S; Das BB
    Eur J Med Chem; 2015 Sep; 102():540-51. PubMed ID: 26312433
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of potent indenoisoquinoline topoisomerase I poisons lacking the 3-nitro toxicophore.
    Beck DE; Abdelmalak M; Lv W; Reddy PV; Tender GS; O'Neill E; Agama K; Marchand C; Pommier Y; Cushman M
    J Med Chem; 2015 May; 58(9):3997-4015. PubMed ID: 25909279
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons.
    Beck DE; Lv W; Abdelmalak M; Plescia CB; Agama K; Marchand C; Pommier Y; Cushman M
    Bioorg Med Chem; 2016 Apr; 24(7):1469-79. PubMed ID: 26906474
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I.
    Elsayed MSA; Su Y; Wang P; Sethi T; Agama K; Ravji A; Redon CE; Kiselev E; Horzmann KA; Freeman JL; Pommier Y; Cushman M
    J Med Chem; 2017 Jul; 60(13):5364-5376. PubMed ID: 28657311
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.
    Sooryakumar D; Dexheimer TS; Teicher BA; Pommier Y
    Mol Cancer Ther; 2011 Aug; 10(8):1490-9. PubMed ID: 21636699
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis and biological evaluation of 3-substituted indenoisoquinoline derivatives as topoisomerase I inhibitors.
    Zhao Q; Xu X; Xie Z; Liu X; You Q; Guo Q; Zhong Y; Li Z
    Bioorg Med Chem Lett; 2016 Feb; 26(3):1068-1072. PubMed ID: 26725027
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents.
    Kiselev E; DeGuire S; Morrell A; Agama K; Dexheimer TS; Pommier Y; Cushman M
    J Med Chem; 2011 Sep; 54(17):6106-16. PubMed ID: 21823606
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors.
    Yu LM; Zhang XR; Li XB; Yang Y; Wei HY; He XX; Gu LQ; Huang ZS; Pommier Y; An LK
    Eur J Med Chem; 2015 Aug; 101():525-33. PubMed ID: 26188908
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
    Zhang XR; Wang HW; Tang WL; Zhang Y; Yang H; Hu DX; Ravji A; Marchand C; Kiselev E; Ofori-Atta K; Agama K; Pommier Y; An LK
    J Med Chem; 2018 Nov; 61(22):9908-9930. PubMed ID: 30336023
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.