BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

255 related articles for article (PubMed ID: 21091656)

  • 1. Pregnane X receptor- and CYP3A4-humanized mouse models and their applications.
    Cheng J; Ma X; Gonzalez FJ
    Br J Pharmacol; 2011 Jun; 163(3):461-8. PubMed ID: 21091656
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.
    Ma X; Cheung C; Krausz KW; Shah YM; Wang T; Idle JR; Gonzalez FJ
    Drug Metab Dispos; 2008 Dec; 36(12):2506-12. PubMed ID: 18799805
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of clinically used drugs that activate pregnane X receptors.
    Shukla SJ; Sakamuru S; Huang R; Moeller TA; Shinn P; Vanleer D; Auld DS; Austin CP; Xia M
    Drug Metab Dispos; 2011 Jan; 39(1):151-9. PubMed ID: 20966043
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
    Kobayashi K; Kuze J; Abe S; Takehara S; Minegishi G; Igarashi K; Kitajima S; Kanno J; Yamamoto T; Oshimura M; Kazuki Y
    Mol Pharmacol; 2019 Nov; 96(5):600-608. PubMed ID: 31455676
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity.
    Cheng J; Ma X; Krausz KW; Idle JR; Gonzalez FJ
    Drug Metab Dispos; 2009 Aug; 37(8):1611-21. PubMed ID: 19460945
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
    Casabar RC; Das PC; Dekrey GK; Gardiner CS; Cao Y; Rose RL; Wallace AD
    Toxicol Appl Pharmacol; 2010 Jun; 245(3):335-43. PubMed ID: 20361990
    [TBL] [Abstract][Full Text] [Related]  

  • 7. PXR/CYP3A4-humanized mice for studying drug-drug interactions involving intestinal P-glycoprotein.
    Holmstock N; Gonzalez FJ; Baes M; Annaert P; Augustijns P
    Mol Pharm; 2013 Mar; 10(3):1056-62. PubMed ID: 23360470
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Role of pregnane X receptor in obesity and glucose homeostasis in male mice.
    Spruiell K; Richardson RM; Cullen JM; Awumey EM; Gonzalez FJ; Gyamfi MA
    J Biol Chem; 2014 Feb; 289(6):3244-61. PubMed ID: 24362030
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of human pregnane X receptor in high fat diet-induced obesity in pre-menopausal female mice.
    Spruiell K; Jones DZ; Cullen JM; Awumey EM; Gonzalez FJ; Gyamfi MA
    Biochem Pharmacol; 2014 Jun; 89(3):399-412. PubMed ID: 24721462
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Functional evolution of the pregnane X receptor.
    Iyer M; Reschly EJ; Krasowski MD
    Expert Opin Drug Metab Toxicol; 2006 Jun; 2(3):381-97. PubMed ID: 16863441
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction.
    Vignati LA; Bogni A; Grossi P; Monshouwer M
    Toxicology; 2004 Jun; 199(1):23-33. PubMed ID: 15125996
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mg2+/Mn2+-dependent phosphatase 1A is involved in regulating pregnane X receptor-mediated cytochrome p450 3A4 gene expression.
    Pondugula SR; Flannery PC; Apte U; Babu JR; Geetha T; Rege SD; Chen T; Abbott KL
    Drug Metab Dispos; 2015 Mar; 43(3):385-91. PubMed ID: 25561723
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CYP3A4 and pregnane X receptor humanized mice.
    Gonzalez FJ
    J Biochem Mol Toxicol; 2007; 21(4):158-62. PubMed ID: 17936928
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.
    Wang H; Li H; Moore LB; Johnson MD; Maglich JM; Goodwin B; Ittoop OR; Wisely B; Creech K; Parks DJ; Collins JL; Willson TM; Kalpana GV; Venkatesh M; Xie W; Cho SY; Roboz J; Redinbo M; Moore JT; Mani S
    Mol Endocrinol; 2008 Apr; 22(4):838-57. PubMed ID: 18096694
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor.
    Ding X; Lichti K; Staudinger JL
    Toxicol Sci; 2006 Jun; 91(2):448-55. PubMed ID: 16547076
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.
    Kanno Y; Tanuma N; Yazawa S; Zhao S; Inaba M; Nakamura S; Nemoto K; Inouye Y
    Drug Metab Dispos; 2016 Aug; 44(8):1158-63. PubMed ID: 27197997
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition.
    Antolino-Lobo I; Meulenbelt J; Nijmeijer SM; Maas-Bakker RF; Meijerman I; van den Berg M; van Duursen MB
    Toxicol Lett; 2011 May; 203(1):82-91. PubMed ID: 21402137
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice.
    Johnson CH; Bonzo JA; Cheng J; Krausz KW; Kang DW; Luecke H; Idle JR; Gonzalez FJ
    Drug Metab Dispos; 2013 Feb; 41(2):406-13. PubMed ID: 23160821
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor.
    Zhang X; Wang Y; Ma Z; Liang Q; Tang X; Hu D; Tan H; Xiao C; Gao Y
    Drug Des Devel Ther; 2015; 9():6343-62. PubMed ID: 26674743
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation.
    Cheng J; Shah YM; Ma X; Pang X; Tanaka T; Kodama T; Krausz KW; Gonzalez FJ
    J Pharmacol Exp Ther; 2010 Oct; 335(1):32-41. PubMed ID: 20627999
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.