678 related articles for article (PubMed ID: 21092856)
1. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.
Hu F; Padukkavidana T; Vægter CB; Brady OA; Zheng Y; Mackenzie IR; Feldman HH; Nykjaer A; Strittmatter SM
Neuron; 2010 Nov; 68(4):654-67. PubMed ID: 21092856
[TBL] [Abstract][Full Text] [Related]
2. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency.
Lee WC; Almeida S; Prudencio M; Caulfield TR; Zhang YJ; Tay WM; Bauer PO; Chew J; Sasaguri H; Jansen-West KR; Gendron TF; Stetler CT; Finch N; Mackenzie IR; Rademakers R; Gao FB; Petrucelli L
Hum Mol Genet; 2014 Mar; 23(6):1467-78. PubMed ID: 24163244
[TBL] [Abstract][Full Text] [Related]
3. Progranulin regulates neuronal outgrowth independent of sortilin.
Gass J; Lee WC; Cook C; Finch N; Stetler C; Jansen-West K; Lewis J; Link CD; Rademakers R; Nykjær A; Petrucelli L
Mol Neurodegener; 2012 Jul; 7():33. PubMed ID: 22781549
[TBL] [Abstract][Full Text] [Related]
4. Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by
Holler CJ; Taylor G; Deng Q; Kukar T
eNeuro; 2017; 4(4):. PubMed ID: 28828399
[TBL] [Abstract][Full Text] [Related]
5. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
Holler CJ; Taylor G; McEachin ZT; Deng Q; Watkins WJ; Hudson K; Easley CA; Hu WT; Hales CM; Rossoll W; Bassell GJ; Kukar T
Mol Neurodegener; 2016 Jun; 11(1):46. PubMed ID: 27341800
[TBL] [Abstract][Full Text] [Related]
6. Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
Chen X; Chang J; Deng Q; Xu J; Nguyen TA; Martens LH; Cenik B; Taylor G; Hudson KF; Chung J; Yu K; Yu P; Herz J; Farese RV; Kukar T; Tansey MG
J Neurosci; 2013 May; 33(21):9202-13. PubMed ID: 23699531
[TBL] [Abstract][Full Text] [Related]
7. Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers.
Alquézar C; de la Encarnación A; Moreno F; López de Munain A; Martín-Requero Á
J Psychiatry Neurosci; 2016 Jun; 41(4):225-39. PubMed ID: 26624524
[TBL] [Abstract][Full Text] [Related]
8. The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding.
De Muynck L; Herdewyn S; Beel S; Scheveneels W; Van Den Bosch L; Robberecht W; Van Damme P
Neurobiol Aging; 2013 Nov; 34(11):2541-7. PubMed ID: 23706646
[TBL] [Abstract][Full Text] [Related]
9. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
Zhou X; Sun L; Bastos de Oliveira F; Qi X; Brown WJ; Smolka MB; Sun Y; Hu F
J Cell Biol; 2015 Sep; 210(6):991-1002. PubMed ID: 26370502
[TBL] [Abstract][Full Text] [Related]
10. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
Huang M; Modeste E; Dammer E; Merino P; Taylor G; Duong DM; Deng Q; Holler CJ; Gearing M; Dickson D; Seyfried NT; Kukar T
Acta Neuropathol Commun; 2020 Oct; 8(1):163. PubMed ID: 33028409
[TBL] [Abstract][Full Text] [Related]
11. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
Martens LH; Zhang J; Barmada SJ; Zhou P; Kamiya S; Sun B; Min SW; Gan L; Finkbeiner S; Huang EJ; Farese RV
J Clin Invest; 2012 Nov; 122(11):3955-9. PubMed ID: 23041626
[TBL] [Abstract][Full Text] [Related]
12. Inter-Species Differences in Regulation of the Progranulin-Sortilin Axis in TDP-43 Cell Models of Neurodegeneration.
Gumina V; Onesto E; Colombrita C; Maraschi A; Silani V; Ratti A
Int J Mol Sci; 2019 Nov; 20(23):. PubMed ID: 31766750
[TBL] [Abstract][Full Text] [Related]
13. TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
Nicholson AM; Finch NA; Wojtas A; Baker MC; Perkerson RB; Castanedes-Casey M; Rousseau L; Benussi L; Binetti G; Ghidoni R; Hsiung GY; Mackenzie IR; Finger E; Boeve BF; Ertekin-Taner N; Graff-Radford NR; Dickson DW; Rademakers R
J Neurochem; 2013 Sep; 126(6):781-91. PubMed ID: 23742080
[TBL] [Abstract][Full Text] [Related]
14. Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor.
Prudencio M; Jansen-West KR; Lee WC; Gendron TF; Zhang YJ; Xu YF; Gass J; Stuani C; Stetler C; Rademakers R; Dickson DW; Buratti E; Petrucelli L
Proc Natl Acad Sci U S A; 2012 Dec; 109(52):21510-5. PubMed ID: 23236149
[TBL] [Abstract][Full Text] [Related]
15. Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
Mohan S; Sampognaro PJ; Argouarch AR; Maynard JC; Welch M; Patwardhan A; Courtney EC; Zhang J; Mason A; Li KH; Huang EJ; Seeley WW; Miller BL; Burlingame A; Jacobson MP; Kao AW
Mol Neurodegener; 2021 Aug; 16(1):51. PubMed ID: 34344440
[TBL] [Abstract][Full Text] [Related]
16. Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia.
Kurnellas M; Mitra A; Schwabe T; Paul R; Arrant AE; Roberson ED; Ward M; Yeh F; Long H; Rosenthal A
J Transl Med; 2023 Jun; 21(1):387. PubMed ID: 37322482
[TBL] [Abstract][Full Text] [Related]
17. Increasing progranulin levels and blockade of the ERK1/2 pathway: upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia.
Alquezar C; Esteras N; de la Encarnación A; Moreno F; López de Munain A; Martín-Requero Á
Eur Neuropsychopharmacol; 2015 Mar; 25(3):386-403. PubMed ID: 25624003
[TBL] [Abstract][Full Text] [Related]
18. The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C.
Zhou X; Sullivan PM; Sun L; Hu F
J Neurochem; 2017 Oct; 143(2):236-243. PubMed ID: 28640985
[TBL] [Abstract][Full Text] [Related]
19. Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
Tanaka Y; Suzuki G; Matsuwaki T; Hosokawa M; Serrano G; Beach TG; Yamanouchi K; Hasegawa M; Nishihara M
Hum Mol Genet; 2017 Mar; 26(5):969-988. PubMed ID: 28073925
[TBL] [Abstract][Full Text] [Related]
20. TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.
Chen-Plotkin AS; Unger TL; Gallagher MD; Bill E; Kwong LK; Volpicelli-Daley L; Busch JI; Akle S; Grossman M; Van Deerlin V; Trojanowski JQ; Lee VM
J Neurosci; 2012 Aug; 32(33):11213-27. PubMed ID: 22895706
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]