BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

197 related articles for article (PubMed ID: 21094165)

  • 1. Visualizing active-site dynamics in single crystals of HePTP: opening of the WPD loop involves coordinated movement of the E loop.
    Critton DA; Tautz L; Page R
    J Mol Biol; 2011 Jan; 405(3):619-29. PubMed ID: 21094165
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis of substrate recognition by hematopoietic tyrosine phosphatase.
    Critton DA; Tortajada A; Stetson G; Peti W; Page R
    Biochemistry; 2008 Dec; 47(50):13336-45. PubMed ID: 19053285
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: structure of a KIM phosphatase with phosphate bound at the active site.
    Mustelin T; Tautz L; Page R
    J Mol Biol; 2005 Nov; 354(1):150-63. PubMed ID: 16226275
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
    Eswaran J; von Kries JP; Marsden B; Longman E; Debreczeni JE; Ugochukwu E; Turnbull A; Lee WH; Knapp S; Barr AJ
    Biochem J; 2006 May; 395(3):483-91. PubMed ID: 16441242
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation.
    Szedlacsek SE; Aricescu AR; Fulga TA; Renault L; Scheidig AJ
    J Mol Biol; 2001 Aug; 311(3):557-68. PubMed ID: 11493009
    [TBL] [Abstract][Full Text] [Related]  

  • 6. SHP family protein tyrosine phosphatases adopt canonical active-site conformations in the apo and phosphate-bound states.
    Alicea-Velazquez NL; Boggon TJ
    Protein Pept Lett; 2013 Sep; 20(9):1039-48. PubMed ID: 23514039
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.
    Sheriff S; Beno BR; Zhai W; Kostich WA; McDonnell PA; Kish K; Goldfarb V; Gao M; Kiefer SE; Yanchunas J; Huang Y; Shi S; Zhu S; Dzierba C; Bronson J; Macor JE; Appiah KK; Westphal RS; O'Connell J; Gerritz SW
    J Med Chem; 2011 Oct; 54(19):6548-62. PubMed ID: 21882820
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Conservative tryptophan mutants of the protein tyrosine phosphatase YopH exhibit impaired WPD-loop function and crystallize with divanadate esters in their active sites.
    Moise G; Gallup NM; Alexandrova AN; Hengge AC; Johnson SJ
    Biochemistry; 2015 Oct; 54(42):6490-500. PubMed ID: 26445170
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop.
    Xiao P; Wang X; Wang HM; Fu XL; Cui FA; Yu X; Wen SS; Bi WX; Sun JP
    Int J Biochem Cell Biol; 2014 Dec; 57():84-95. PubMed ID: 25450460
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dynamics of the WPD loop of the Yersinia protein tyrosine phosphatase.
    Hu X; Stebbins CE
    Biophys J; 2006 Aug; 91(3):948-56. PubMed ID: 16698773
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Relation between the flexibility of the WPD loop and the activity of the catalytic domain of protein tyrosine phosphatase SHP-1.
    Yang J; Niu T; Zhang A; Mishra AK; Zhao ZJ; Zhou GW
    J Cell Biochem; 2001; 84(1):47-55. PubMed ID: 11746515
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The molecular details of WPD-loop movement differ in the protein-tyrosine phosphatases YopH and PTP1B.
    Brandão TA; Johnson SJ; Hengge AC
    Arch Biochem Biophys; 2012 Sep; 525(1):53-9. PubMed ID: 22698963
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases.
    Moise G; Morales Y; Beaumont V; Caradonna T; Loria JP; Johnson SJ; Hengge AC
    Biochemistry; 2018 Sep; 57(36):5315-5326. PubMed ID: 30110154
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Engineered inhibitor sensitivity in the WPD loop of a protein tyrosine phosphatase.
    Zhang XY; Bishop AC
    Biochemistry; 2008 Apr; 47(15):4491-500. PubMed ID: 18358001
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential oxidation of protein-tyrosine phosphatases.
    Groen A; Lemeer S; van der Wijk T; Overvoorde J; Heck AJ; Ostman A; Barford D; Slijper M; den Hertog J
    J Biol Chem; 2005 Mar; 280(11):10298-304. PubMed ID: 15623519
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sequence - dynamics - function relationships in protein tyrosine phosphatases.
    Crean RM; Corbella M; Calixto AR; Hengge AC; Kamerlin SCL
    QRB Discov; 2024; 5():e4. PubMed ID: 38689874
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases.
    Shen R; Crean RM; Johnson SJ; Kamerlin SCL; Hengge AC
    JACS Au; 2021 May; 1(5):646-659. PubMed ID: 34308419
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis.
    Adams J; Thornton BP; Tabernero L
    Int J Mol Sci; 2021 Nov; 22(22):. PubMed ID: 34830087
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1.
    Yang J; Liang X; Niu T; Meng W; Zhao Z; Zhou GW
    J Biol Chem; 1998 Oct; 273(43):28199-207. PubMed ID: 9774441
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases.
    Crean RM; Biler M; van der Kamp MW; Hengge AC; Kamerlin SCL
    J Am Chem Soc; 2021 Mar; 143(10):3830-3845. PubMed ID: 33661624
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.