BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

231 related articles for article (PubMed ID: 21109200)

  • 1. The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers.
    Williams SL; Huang J; Edwards YJ; Ulloa RH; Dillon LM; Prolla TA; Vance JM; Moraes CT; Züchner S
    Cell Metab; 2010 Dec; 12(6):675-82. PubMed ID: 21109200
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA.
    Wanrooij S; Luoma P; van Goethem G; van Broeckhoven C; Suomalainen A; Spelbrink JN
    Nucleic Acids Res; 2004; 32(10):3053-64. PubMed ID: 15181170
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging.
    Edgar D; Trifunovic A
    Aging (Albany NY); 2009 Dec; 1(12):1028-32. PubMed ID: 20157586
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice.
    Dai Y; Clark J; Zheng K; Kujoth GC; Prolla TA; Simon DK
    Neurotoxicol Teratol; 2014; 46():62-7. PubMed ID: 25450660
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice.
    Kolesar JE; Safdar A; Abadi A; MacNeil LG; Crane JD; Tarnopolsky MA; Kaufman BA
    Free Radic Biol Med; 2014 Oct; 75():241-51. PubMed ID: 25106705
    [TBL] [Abstract][Full Text] [Related]  

  • 6. MitoRCA-seq reveals unbalanced cytocine to thymine transition in Polg mutant mice.
    Ni T; Wei G; Shen T; Han M; Lian Y; Fu H; Luo Y; Yang Y; Liu J; Wakabayashi Y; Li Z; Finkel T; Xu H; Zhu J
    Sci Rep; 2015 Jul; 5():12049. PubMed ID: 26212336
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA.
    Bailey LJ; Cluett TJ; Reyes A; Prolla TA; Poulton J; Leeuwenburgh C; Holt IJ
    Nucleic Acids Res; 2009 Apr; 37(7):2327-35. PubMed ID: 19244310
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma.
    Someya S; Yamasoba T; Kujoth GC; Pugh TD; Weindruch R; Tanokura M; Prolla TA
    Neurobiol Aging; 2008 Jul; 29(7):1080-92. PubMed ID: 17363114
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection.
    Maclaine KD; Stebbings KA; Llano DA; Havird JC
    BMC Genom Data; 2021 Nov; 22(1):52. PubMed ID: 34823474
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells.
    Spelbrink JN; Toivonen JM; Hakkaart GA; Kurkela JM; Cooper HM; Lehtinen SK; Lecrenier N; Back JW; Speijer D; Foury F; Jacobs HT
    J Biol Chem; 2000 Aug; 275(32):24818-28. PubMed ID: 10827171
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Association of novel POLG mutations and multiple mitochondrial DNA deletions with variable clinical phenotypes in a Spanish population.
    González-Vioque E; Blázquez A; Fernández-Moreira D; Bornstein B; Bautista J; Arpa J; Navarro C; Campos Y; Fernández-Moreno MA; Garesse R; Arenas J; Martín MA
    Arch Neurol; 2006 Jan; 63(1):107-11. PubMed ID: 16401742
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.
    Kim MJ; Haroon S; Chen GD; Ding D; Wanagat J; Liu L; Zhang Y; White K; Park HJ; Han C; Boyd K; Caicedo I; Evans K; Linser PJ; Tanokura M; Prolla T; Salvi R; Vermulst M; Someya S
    Exp Gerontol; 2019 Oct; 125():110675. PubMed ID: 31344454
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Premature aging is associated with higher levels of 8-oxoguanine and increased DNA damage in the Polg mutator mouse.
    Yu T; Slone J; Liu W; Barnes R; Opresko PL; Wark L; Mai S; Horvath S; Huang T
    Aging Cell; 2022 Sep; 21(9):e13669. PubMed ID: 35993394
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice.
    Safdar A; Khrapko K; Flynn JM; Saleem A; De Lisio M; Johnston AP; Kratysberg Y; Samjoo IA; Kitaoka Y; Ogborn DI; Little JP; Raha S; Parise G; Akhtar M; Hettinga BP; Rowe GC; Arany Z; Prolla TA; Tarnopolsky MA
    Skelet Muscle; 2016; 6():7. PubMed ID: 26834962
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Do mtDNA deletions drive premature aging in mtDNA mutator mice?
    Kraytsberg Y; Simon DK; Turnbull DM; Khrapko K
    Aging Cell; 2009 Aug; 8(4):502-6. PubMed ID: 19416127
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis.
    Safdar A; Annis S; Kraytsberg Y; Laverack C; Saleem A; Popadin K; Woods DC; Tilly JL; Khrapko K
    Curr Opin Genet Dev; 2016 Jun; 38():127-132. PubMed ID: 27497229
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain.
    Hauser DN; Dillman AA; Ding J; Li Y; Cookson MR
    PLoS One; 2014; 9(4):e94646. PubMed ID: 24722488
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain.
    Clark-Matott J; Saleem A; Dai Y; Shurubor Y; Ma X; Safdar A; Beal MF; Tarnopolsky M; Simon DK
    Neurobiol Aging; 2015 Nov; 36(11):2972-2983. PubMed ID: 26294258
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions.
    Nissanka N; Bacman SR; Plastini MJ; Moraes CT
    Nat Commun; 2018 Jun; 9(1):2491. PubMed ID: 29950568
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Different faces of mitochondrial DNA mutators.
    Szczepanowska K; Trifunovic A
    Biochim Biophys Acta; 2015 Nov; 1847(11):1362-72. PubMed ID: 26014346
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.