144 related articles for article (PubMed ID: 21112258)
1. Evidence of the formation of direct covalent adducts of primaquine, 2-tert-butylprimaquine (NP-96) and monohydroxy metabolite of NP-96 with glutathione and N-acetylcysteine.
Garg A; Prasad B; Takwani H; Jain M; Jain R; Singh S
J Chromatogr B Analyt Technol Biomed Life Sci; 2011 Jan; 879(1):1-7. PubMed ID: 21112258
[TBL] [Abstract][Full Text] [Related]
2. Development and validation of a sensitive and selective UHPLC-MS/MS method for quantitation of an investigational anti-malarial compound, 2-tert-butylprimaquine (NP-96) in rat plasma, and its application in a preclinical pharmacokinetic study.
Mayatra SJ; Prasad B; Jain M; Jain R; Singh S
J Pharm Biomed Anal; 2010 Jul; 52(3):410-5. PubMed ID: 19574014
[TBL] [Abstract][Full Text] [Related]
3. Rapid detection and characterization of in vitro and urinary N-acetyl-L-cysteine conjugates using quadrupole-linear ion trap mass spectrometry and polarity switching.
Jian W; Yao M; Zhang D; Zhu M
Chem Res Toxicol; 2009 Jul; 22(7):1246-55. PubMed ID: 19527004
[TBL] [Abstract][Full Text] [Related]
4. Improved detection of reactive metabolites with a bromine-containing glutathione analog using mass defect and isotope pattern matching.
Leblanc A; Shiao TC; Roy R; Sleno L
Rapid Commun Mass Spectrom; 2010 May; 24(9):1241-50. PubMed ID: 20391594
[TBL] [Abstract][Full Text] [Related]
5. In vitro metabolism of diphenyl diselenide in rat liver fractions. Conjugation with GSH and binding to thiol groups.
Prigol M; Nogueira CW; Zeni G; Bronze MR; Constantino L
Chem Biol Interact; 2012 Dec; 200(2-3):65-72. PubMed ID: 23022272
[TBL] [Abstract][Full Text] [Related]
6. A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass spectrometry and novel quaternary ammonium glutathione analogues.
Soglia JR; Contillo LG; Kalgutkar AS; Zhao S; Hop CE; Boyd JG; Cole MJ
Chem Res Toxicol; 2006 Mar; 19(3):480-90. PubMed ID: 16544956
[TBL] [Abstract][Full Text] [Related]
7. A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.
Lim HK; Chen J; Cook K; Sensenhauser C; Silva J; Evans DC
Rapid Commun Mass Spectrom; 2008 Apr; 22(8):1295-311. PubMed ID: 18383206
[TBL] [Abstract][Full Text] [Related]
8. Identification and quantification of glutathione adducts of clozapine using ultra-high-performance liquid chromatography with orthogonal acceleration time-of-flight mass spectrometry and inductively coupled plasma mass spectrometry.
MacDonald C; Smith C; Michopoulos F; Weaver R; Wilson ID
Rapid Commun Mass Spectrom; 2011 Jul; 25(13):1787-93. PubMed ID: 21638353
[TBL] [Abstract][Full Text] [Related]
9. A liquid chromatography/tandem mass spectrometry method for detecting UGT-mediated bioactivation of drugs as their N-acetylcysteine adducts in human liver microsomes.
Harada H; Endo T; Momose Y; Kusama H
Rapid Commun Mass Spectrom; 2009 Mar; 23(5):564-70. PubMed ID: 19177506
[TBL] [Abstract][Full Text] [Related]
10. Biomarkers of furan exposure by metabolic profiling of rat urine with liquid chromatography-tandem mass spectrometry and principal component analysis.
Kellert M; Wagner S; Lutz U; Lutz WK
Chem Res Toxicol; 2008 Mar; 21(3):761-8. PubMed ID: 18269250
[TBL] [Abstract][Full Text] [Related]
11. Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.
Kassahun K; Farrell K; Abbott F
Drug Metab Dispos; 1991; 19(2):525-35. PubMed ID: 1676665
[TBL] [Abstract][Full Text] [Related]
12. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
Zhuo X; Zhao W; Zheng J; Humphreys WG; Shu YZ; Zhu M
Chem Biol Interact; 2009 Oct; 181(2):227-35. PubMed ID: 19576871
[TBL] [Abstract][Full Text] [Related]
13. Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
Ruan Q; Zhu M
Chem Res Toxicol; 2010 May; 23(5):909-17. PubMed ID: 20297803
[TBL] [Abstract][Full Text] [Related]
14. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
[TBL] [Abstract][Full Text] [Related]
15. Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
Chen Q; Doss GA; Tung EC; Liu W; Tang YS; Braun MP; Didolkar V; Strauss JR; Wang RW; Stearns RA; Evans DC; Baillie TA; Tang W
Drug Metab Dispos; 2006 Jan; 34(1):145-51. PubMed ID: 16251255
[TBL] [Abstract][Full Text] [Related]
16. Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition.
Yan Z; Caldwell GW; Maher N
Anal Chem; 2008 Aug; 80(16):6410-22. PubMed ID: 18642850
[TBL] [Abstract][Full Text] [Related]
17. Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering.
Zhu M; Ma L; Zhang H; Humphreys WG
Anal Chem; 2007 Nov; 79(21):8333-41. PubMed ID: 17918967
[TBL] [Abstract][Full Text] [Related]
18. Conjugation of keto fatty acids to glutathione in plant tissues. Characterization and quantification by HPLC-tandem mass spectrometry.
Davoine C; Douki T; Iacazio G; Montillet JL; Triantaphylidès C
Anal Chem; 2005 Nov; 77(22):7366-72. PubMed ID: 16285687
[TBL] [Abstract][Full Text] [Related]
19. Rat liver microsomal and mitochondrial metabolism of primaquine in vitro.
Ni YC; Xu YQ; Wang MJ
Zhongguo Yao Li Xue Bao; 1992 Sep; 13(5):431-5. PubMed ID: 1300047
[TBL] [Abstract][Full Text] [Related]
20. Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes.
Yu LJ; Chen Y; Deninno MP; O'Connell TN; Hop CE
Drug Metab Dispos; 2005 Apr; 33(4):484-8. PubMed ID: 15640374
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
