BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

100 related articles for article (PubMed ID: 21118151)

  • 1. Loss of the tumour-suppressor genes CHK2 and BRCA1 results in chromosomal instability.
    Stolz A; Ertych N; Bastians H
    Biochem Soc Trans; 2010 Dec; 38(6):1704-8. PubMed ID: 21118151
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Tumor suppressor CHK2: regulator of DNA damage response and mediator of chromosomal stability.
    Stolz A; Ertych N; Bastians H
    Clin Cancer Res; 2011 Feb; 17(3):401-5. PubMed ID: 21088254
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.
    Stolz A; Ertych N; Kienitz A; Vogel C; Schneider V; Fritz B; Jacob R; Dittmar G; Weichert W; Petersen I; Bastians H
    Nat Cell Biol; 2010 May; 12(5):492-9. PubMed ID: 20364141
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.
    Ertych N; Stolz A; Valerius O; Braus GH; Bastians H
    Proc Natl Acad Sci U S A; 2016 Feb; 113(7):1817-22. PubMed ID: 26831064
    [TBL] [Abstract][Full Text] [Related]  

  • 5. BRCA1 is regulated by Chk2 in response to spindle damage.
    Chabalier-Taste C; Racca C; Dozier C; Larminat F
    Biochim Biophys Acta; 2008 Dec; 1783(12):2223-33. PubMed ID: 18804494
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.
    Kim SS; Cao L; Li C; Xu X; Huber LJ; Chodosh LA; Deng CX
    Mol Cell Biol; 2004 Nov; 24(21):9498-507. PubMed ID: 15485917
    [TBL] [Abstract][Full Text] [Related]  

  • 7. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.
    Lee JS; Collins KM; Brown AL; Lee CH; Chung JH
    Nature; 2000 Mar; 404(6774):201-4. PubMed ID: 10724175
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1.
    Grigorova M; Staines JM; Ozdag H; Caldas C; Edwards PA
    Cytogenet Genome Res; 2004; 104(1-4):333-40. PubMed ID: 15162061
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.
    Wang HC; Chou WC; Shieh SY; Shen CY
    Cancer Res; 2006 Feb; 66(3):1391-400. PubMed ID: 16452194
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage.
    Shang ZF; Huang B; Xu QZ; Zhang SM; Fan R; Liu XD; Wang Y; Zhou PK
    Cancer Res; 2010 May; 70(9):3657-66. PubMed ID: 20406977
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability.
    Lüddecke S; Ertych N; Stenzinger A; Weichert W; Beissbarth T; Dyczkowski J; Gaedcke J; Valerius O; Braus GH; Kschischo M; Bastians H
    Oncogene; 2016 May; 35(18):2398-406. PubMed ID: 26300001
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.
    Castedo M; Perfettini JL; Roumier T; Yakushijin K; Horne D; Medema R; Kroemer G
    Oncogene; 2004 May; 23(25):4353-61. PubMed ID: 15048074
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Collaboration of Brca1 and Chk2 in tumorigenesis.
    McPherson JP; Lemmers B; Hirao A; Hakem A; Abraham J; Migon E; Matysiak-Zablocki E; Tamblyn L; Sanchez-Sweatman O; Khokha R; Squire J; Hande MP; Mak TW; Hakem R
    Genes Dev; 2004 May; 18(10):1144-53. PubMed ID: 15131084
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments.
    Lampson MA; Kapoor TM
    Nat Cell Biol; 2005 Jan; 7(1):93-8. PubMed ID: 15592459
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining.
    Zhuang J; Zhang J; Willers H; Wang H; Chung JH; van Gent DC; Hallahan DE; Powell SN; Xia F
    Cancer Res; 2006 Feb; 66(3):1401-8. PubMed ID: 16452195
    [TBL] [Abstract][Full Text] [Related]  

  • 16. BRCA1 is required for meiotic spindle assembly and spindle assembly checkpoint activation in mouse oocytes.
    Xiong B; Li S; Ai JS; Yin S; Ouyang YC; Sun SC; Chen DY; Sun QY
    Biol Reprod; 2008 Oct; 79(4):718-26. PubMed ID: 18596218
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer.
    Weaver Z; Montagna C; Xu X; Howard T; Gadina M; Brodie SG; Deng CX; Ried T
    Oncogene; 2002 Aug; 21(33):5097-107. PubMed ID: 12140760
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CHK2-dependent phosphorylation of BRCA1 in hypoxia.
    Gibson SL; Bindra RS; Glazer PM
    Radiat Res; 2006 Oct; 166(4):646-51. PubMed ID: 17007555
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis.
    Venoux M; Basbous J; Berthenet C; Prigent C; Fernandez A; Lamb NJ; Rouquier S
    Hum Mol Genet; 2008 Jan; 17(2):215-24. PubMed ID: 17925329
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer.
    Tommiska J; Bartkova J; Heinonen M; Hautala L; Kilpivaara O; Eerola H; Aittomäki K; Hofstetter B; Lukas J; von Smitten K; Blomqvist C; Ristimäki A; Heikkilä P; Bartek J; Nevanlinna H
    Oncogene; 2008 Apr; 27(17):2501-6. PubMed ID: 17982490
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.