BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

83 related articles for article (PubMed ID: 21122808)

  • 1. Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination.
    Hodgson RA; Hyde LA; Guthrie DH; Cohen-Williams ME; Leach PT; Kazdoba TM; Bleickardt CJ; Lu SX; Parker EM; Varty GB
    Pharmacol Biochem Behav; 2011 Apr; 98(2):181-7. PubMed ID: 21122808
    [TBL] [Abstract][Full Text] [Related]  

  • 2. mGluR5, but not mGluR1, antagonist modifies MK-801-induced locomotor activity and deficit of prepulse inhibition.
    Pietraszek M; Gravius A; Schäfer D; Weil T; Trifanova D; Danysz W
    Neuropharmacology; 2005 Jul; 49(1):73-85. PubMed ID: 15992582
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allosteric metabotropic glutamate receptor 1 antagonist, FTIDC [4-[1-(2-fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide].
    Satow A; Maehara S; Ise S; Hikichi H; Fukushima M; Suzuki G; Kimura T; Tanak T; Ito S; Kawamoto H; Ohta H
    J Pharmacol Exp Ther; 2008 Aug; 326(2):577-86. PubMed ID: 18487514
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task.
    Steckler T; Oliveira AF; Van Dyck C; Van Craenendonck H; Mateus AM; Langlois X; Lesage AS; Prickaerts J
    Behav Brain Res; 2005 Oct; 164(1):52-60. PubMed ID: 16043241
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum.
    Nakao H; Nakao K; Kano M; Aiba A
    Neurosci Res; 2007 Apr; 57(4):538-43. PubMed ID: 17270300
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1.
    Kohara A; Toya T; Tamura S; Watabiki T; Nagakura Y; Shitaka Y; Hayashibe S; Kawabata S; Okada M
    J Pharmacol Exp Ther; 2005 Oct; 315(1):163-9. PubMed ID: 15976016
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
    Kinney GG; O'Brien JA; Lemaire W; Burno M; Bickel DJ; Clements MK; Chen TB; Wisnoski DD; Lindsley CW; Tiller PR; Smith S; Jacobson MA; Sur C; Duggan ME; Pettibone DJ; Conn PJ; Williams DL
    J Pharmacol Exp Ther; 2005 Apr; 313(1):199-206. PubMed ID: 15608073
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
    El-Kouhen O; Lehto SG; Pan JB; Chang R; Baker SJ; Zhong C; Hollingsworth PR; Mikusa JP; Cronin EA; Chu KL; McGaraughty SP; Uchic ME; Miller LN; Rodell NM; Patel M; Bhatia P; Mezler M; Kolasa T; Zheng GZ; Fox GB; Stewart AO; Decker MW; Moreland RB; Brioni JD; Honore P
    Br J Pharmacol; 2006 Nov; 149(6):761-74. PubMed ID: 17016515
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one.
    Satow A; Suzuki G; Maehara S; Hikichi H; Murai T; Murai T; Kawagoe-Takaki H; Hata M; Ito S; Ozaki S; Kawamoto H; Ohta H
    J Pharmacol Exp Ther; 2009 Jul; 330(1):179-90. PubMed ID: 19359526
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC).
    Suzuki G; Kimura T; Satow A; Kaneko N; Fukuda J; Hikichi H; Sakai N; Maehara S; Kawagoe-Takaki H; Hata M; Azuma T; Ito S; Kawamoto H; Ohta H
    J Pharmacol Exp Ther; 2007 Jun; 321(3):1144-53. PubMed ID: 17360958
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats - a comparison.
    Gravius A; Barberi C; Schäfer D; Schmidt WJ; Danysz W
    Neuropharmacology; 2006 Dec; 51(7-8):1146-55. PubMed ID: 16905160
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effect of the class I metabotropic glutamate receptor antagonist AIDA on certain behaviours in rats with experimental chronic hyperammonemia.
    Grzeda E; Wiśniewska RJ
    Adv Med Sci; 2009; 54(2):269-76. PubMed ID: 19875354
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra.
    Cauli O; Llansola M; Erceg S; Felipo V
    J Hepatol; 2006 Nov; 45(5):654-61. PubMed ID: 16982110
    [TBL] [Abstract][Full Text] [Related]  

  • 14. JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist.
    Lavreysen H; Wouters R; Bischoff F; Nóbrega Pereira S; Langlois X; Blokland S; Somers M; Dillen L; Lesage AS
    Neuropharmacology; 2004 Dec; 47(7):961-72. PubMed ID: 15555631
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents.
    Hikichi H; Murai T; Okuda S; Maehara S; Satow A; Ise S; Nishino M; Suzuki G; Takehana H; Hata M; Ohta H
    Eur J Pharmacol; 2010 Aug; 639(1-3):106-14. PubMed ID: 20371227
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Comparison of the effects of mGluR1 and mGluR5 antagonists on the expression of behavioral sensitization to the locomotor effect of morphine and the morphine withdrawal jumping in mice.
    Kotlinska J; Bochenski M
    Eur J Pharmacol; 2007 Mar; 558(1-3):113-8. PubMed ID: 17222405
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improvesoOutcome after brain trauma.
    Faden AI; O'Leary DM; Fan L; Bao W; Mullins PG; Movsesyan VA
    Exp Neurol; 2001 Feb; 167(2):435-44. PubMed ID: 11161632
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice.
    Schröder UH; Müller T; Schreiber R; Stolle A; Zuschratter W; Balschun D; Jork R; Reymann KG
    Neuroscience; 2008 Nov; 157(2):385-95. PubMed ID: 18832015
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Virtual screening for selective allosteric mGluR1 antagonists and structure-activity relationship investigations for coumarine derivatives.
    Noeske T; Jirgensons A; Starchenkovs I; Renner S; Jaunzeme I; Trifanova D; Hechenberger M; Bauer T; Kauss V; Parsons CG; Schneider G; Weil T
    ChemMedChem; 2007 Dec; 2(12):1763-73. PubMed ID: 17868161
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacological antagonism of metabotropic glutamate receptor 1 regulates long-term potentiation and spatial reference memory in the dentate gyrus of freely moving rats via N-methyl-D-aspartate and metabotropic glutamate receptor-dependent mechanisms.
    Naie K; Manahan-Vaughan D
    Eur J Neurosci; 2005 Jan; 21(2):411-21. PubMed ID: 15673440
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.