Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

392 related articles for article (PubMed ID: 21123367)

  • 1. AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor.
    Liu JL; Mao Z; Gallick GE; Yung WK
    Neuro Oncol; 2011 Feb; 13(2):184-94. PubMed ID: 21123367
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma.
    Lu KH; Wu W; Dave B; Slomovitz BM; Burke TW; Munsell MF; Broaddus RR; Walker CL
    Clin Cancer Res; 2008 May; 14(9):2543-50. PubMed ID: 18451215
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells.
    Memmott RM; Gills JJ; Hollingshead M; Powers MC; Chen Z; Kemp B; Kozikowski A; Dennis PA
    Cancer Res; 2008 Jan; 68(2):580-8. PubMed ID: 18199555
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.
    Huang X; Wullschleger S; Shpiro N; McGuire VA; Sakamoto K; Woods YL; McBurnie W; Fleming S; Alessi DR
    Biochem J; 2008 Jun; 412(2):211-21. PubMed ID: 18387000
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade.
    Liu JL; Mao Z; LaFortune TA; Alonso MM; Gallick GE; Fueyo J; Yung WK
    Cancer Res; 2007 Nov; 67(22):11054-63. PubMed ID: 18006852
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway.
    Lin CC; Yeh HH; Huang WL; Yan JJ; Lai WW; Su WP; Chen HH; Su WC
    Am J Respir Cell Mol Biol; 2013 Aug; 49(2):241-50. PubMed ID: 23526220
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.
    Xie Z; Dong Y; Scholz R; Neumann D; Zou MH
    Circulation; 2008 Feb; 117(7):952-62. PubMed ID: 18250273
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Negative regulation of mTOR activity by LKB1-AMPK signaling in non-small cell lung cancer cells.
    Dong LX; Sun LL; Zhang X; Pan L; Lian LJ; Chen Z; Zhong DS
    Acta Pharmacol Sin; 2013 Feb; 34(2):314-8. PubMed ID: 23178462
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation.
    Zhu H; Moriasi CM; Zhang M; Zhao Y; Zou MH
    J Biol Chem; 2013 Jun; 288(23):16495-16505. PubMed ID: 23612973
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis.
    Nagalingam A; Arbiser JL; Bonner MY; Saxena NK; Sharma D
    Breast Cancer Res; 2012 Feb; 14(1):R35. PubMed ID: 22353783
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner.
    Rattan R; Giri S; Hartmann LC; Shridhar V
    J Cell Mol Med; 2011 Jan; 15(1):166-78. PubMed ID: 19874425
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metformin sensitizes insulin signaling through AMPK-mediated PTEN down-regulation in preadipocyte 3T3-L1 cells.
    Lee SK; Lee JO; Kim JH; Kim SJ; You GY; Moon JW; Jung JH; Park SH; Uhm KO; Park JM; Suh PG; Kim HS
    J Cell Biochem; 2011 May; 112(5):1259-67. PubMed ID: 21465524
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The LKB1 tumor suppressor negatively regulates mTOR signaling.
    Shaw RJ; Bardeesy N; Manning BD; Lopez L; Kosmatka M; DePinho RA; Cantley LC
    Cancer Cell; 2004 Jul; 6(1):91-9. PubMed ID: 15261145
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.
    Tripathi DN; Chowdhury R; Trudel LJ; Tee AR; Slack RS; Walker CL; Wogan GN
    Proc Natl Acad Sci U S A; 2013 Aug; 110(32):E2950-7. PubMed ID: 23878245
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways.
    Han S; Khuri FR; Roman J
    Cancer Res; 2006 Jan; 66(1):315-23. PubMed ID: 16397245
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells.
    Dowling RJ; Zakikhani M; Fantus IG; Pollak M; Sonenberg N
    Cancer Res; 2007 Nov; 67(22):10804-12. PubMed ID: 18006825
    [TBL] [Abstract][Full Text] [Related]  

  • 17. AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation.
    Ning J; Clemmons DR
    Mol Endocrinol; 2010 Jun; 24(6):1218-29. PubMed ID: 20363874
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
    Wolff NC; Vega-Rubin-de-Celis S; Xie XJ; Castrillon DH; Kabbani W; Brugarolas J
    Mol Cell Biol; 2011 May; 31(9):1870-84. PubMed ID: 21383064
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.
    Sanli T; Rashid A; Liu C; Harding S; Bristow RG; Cutz JC; Singh G; Wright J; Tsakiridis T
    Int J Radiat Oncol Biol Phys; 2010 Sep; 78(1):221-9. PubMed ID: 20615625
    [TBL] [Abstract][Full Text] [Related]  

  • 20. LKB1/AMPK inhibits TGF-β1 production and the TGF-β signaling pathway in breast cancer cells.
    Li NS; Zou JR; Lin H; Ke R; He XL; Xiao L; Huang D; Luo L; Lv N; Luo Z
    Tumour Biol; 2016 Jun; 37(6):8249-58. PubMed ID: 26718214
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.