These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

243 related articles for article (PubMed ID: 2114100)

  • 1. Mechanisms of 2'-deoxyguanosine toxicity in mouse T-lymphoma cells with purine nucleoside phosphorylase deficiency and resistance to inhibition of ribonucleotide reductase by dGTP.
    Duan DS; Nagashima T; Hoshino T; Waldman F; Pawlak K; Sadee W
    Biochem J; 1990 Jun; 268(3):725-31. PubMed ID: 2114100
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Isolation and characterization of purine-nucleoside phosphorylase-deficient T-lymphoma cells and secondary mutants with altered ribonucleotide reductase: genetic model for immunodeficiency disease.
    Ullman B; Gudas LJ; Clift SM; Martin DW
    Proc Natl Acad Sci U S A; 1979 Mar; 76(3):1074-8. PubMed ID: 108675
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Guanine for DNA synthesis. A compulsory route through ribonucleotide reductase.
    Duan DS; Sadee W
    Biochem J; 1988 Nov; 255(3):1045-8. PubMed ID: 3063254
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanisms of deoxyguanosine lymphotoxicity. Human thymocytes, but not peripheral blood lymphocytes accumulate deoxy-GTP in conditions simulating purine nucleoside phosphorylase deficiency.
    Fairbanks LD; Taddeo A; Duley JA; Simmonds HA
    J Immunol; 1990 Jan; 144(2):485-91. PubMed ID: 2104895
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Deoxyguanosine toxicity in a mouse T lymphoma: relationship to purine nucleoside phosphorylase-associated immune dysfunction.
    Gudas LJ; Ullman B; Cohen A; Martin DW
    Cell; 1978 Jul; 14(3):531-8. PubMed ID: 99243
    [No Abstract]   [Full Text] [Related]  

  • 6. Demonstration of normal and mutant protein M1 subunits of deoxyGTP-resistant ribonucleotide reductase from mutant mouse lymphoma cells.
    Ullman B; Gudas LJ; Caras IW; Eriksson S; Weinberg GL; Wormsted MA; Martin DW
    J Biol Chem; 1981 Oct; 256(19):10189-92. PubMed ID: 7024266
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Functional and mechanistic studies on the toxicity of deoxyguanosine for the in vitro proliferation and differentiation of human peripheral blood B lymphocytes.
    Scharenberg JG; Spaapen LJ; Rijkers GT; Duran M; Staal GE; Zegers BJ
    Eur J Immunol; 1986 Apr; 16(4):381-7. PubMed ID: 3084280
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Different pathways for deoxyguanosine toxicity in T-lymphocytes of various developmental stages.
    Scharenberg JG; Rijkers GT; Spaapen LJ; Toebes EA; Rijksen G; Duran M; Staal GE; Zegers BJ
    Int J Immunopharmacol; 1988; 10(6):675-86. PubMed ID: 2974022
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of purine-nucleoside phosphorylase deficiency.
    Albert D; Bluestein HG; Willis RC; Nette K; Seegmiller JE
    Cell Immunol; 1984 Jul; 86(2):501-9. PubMed ID: 6428752
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor--BCX-1777.
    Bantia S; Ananth SL; Parker CD; Horn LL; Upshaw R
    Int Immunopharmacol; 2003 Jun; 3(6):879-87. PubMed ID: 12781704
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies.
    Bantia S; Parker C; Upshaw R; Cunningham A; Kotian P; Kilpatrick JM; Morris P; Chand P; Babu YS
    Int Immunopharmacol; 2010 Jul; 10(7):784-90. PubMed ID: 20399911
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Deoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblasts.
    Mann GJ; Fox RM
    J Clin Invest; 1986 Nov; 78(5):1261-9. PubMed ID: 3490493
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency.
    Cohen A; Gudas LJ; Ammann AJ; Staal GE; Martin DW
    J Clin Invest; 1978 May; 61(5):1405-9. PubMed ID: 96138
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase.
    Carson DA; Wasson DB; Lakow E; Kamatani N
    Proc Natl Acad Sci U S A; 1982 Jun; 79(12):3848-52. PubMed ID: 6808516
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparison of in vivo efficacy of BCX-1777 and cyclosporin in xenogeneic graft-vs.-host disease: the role of dGTP in antiproliferative action of BCX-1777.
    Banti S; Miller PJ; Parker CD; Ananth SL; Horn LL; Babu YS; Sandhu JS
    Int Immunopharmacol; 2002 Jun; 2(7):913-23. PubMed ID: 12188033
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Deoxyribonucleoside triphosphate metabolism and the mammalian cell cycle. Effects of hydroxyurea on mutant and wild-type mouse S49 T-lymphoma cells.
    Eriksson S; Skog S; Tribukait B; Wallström B
    Exp Cell Res; 1987 Jan; 168(1):79-88. PubMed ID: 3096753
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The biochemistry and pharmacology of PD 116124 (8-amino-2'-nordeoxyguanosine), an inhibitor of purine nucleoside phosphorylase (PNP).
    Dong MK; Scott ME; Schrier DJ; Suto MJ; Sircar JC; Black A; Chang T; Gilbertsen RB
    J Pharmacol Exp Ther; 1992 Jan; 260(1):319-26. PubMed ID: 1530976
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A purine nucleoside phosphorylase (PNP) inhibitor induces apoptosis via caspase-3-like protease activity in MOLT-4 T cells.
    Posmantur R; Wang KK; Nath R; Gilbertsen RB
    Immunopharmacology; 1997 Oct; 37(2-3):231-44. PubMed ID: 9403342
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Correction of purine nucleoside phosphorylase deficiency by retroviral-mediated gene transfer in mouse S49 T cell lymphoma: a model for gene therapy of T cell immunodeficiency.
    Foresman MD; Nelson DM; McIvor RS
    Hum Gene Ther; 1992 Dec; 3(6):625-31. PubMed ID: 1482702
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Deoxyguanosine toxicity on lymphoid cells as a cause for immunosuppression in purine nucleoside phosphorylase deficiency.
    Chan TS
    Cell; 1978 Jul; 14(3):523-30. PubMed ID: 99242
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 13.