These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells. Reddiconto G; Toto C; Palamà I; De Leo S; de Luca E; De Matteis S; Dini L; Passerini CG; Di Renzo N; Maffia M; Coluccia AM Blood; 2012 Mar; 119(10):2335-45. PubMed ID: 22262776 [TBL] [Abstract][Full Text] [Related]
4. Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors. Konig H; Holtz M; Modi H; Manley P; Holyoake TL; Forman SJ; Bhatia R Leukemia; 2008 Apr; 22(4):748-55. PubMed ID: 18273048 [TBL] [Abstract][Full Text] [Related]
5. Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex. Chen M; Gallipoli P; DeGeer D; Sloma I; Forrest DL; Chan M; Lai D; Jorgensen H; Ringrose A; Wang HM; Lambie K; Nakamoto H; Saw KM; Turhan A; Arlinghaus R; Paul J; Stobo J; Barnett MJ; Eaves A; Eaves CJ; Holyoake TL; Jiang X J Natl Cancer Inst; 2013 Mar; 105(6):405-23. PubMed ID: 23446755 [TBL] [Abstract][Full Text] [Related]
6. BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells. Chu S; Holtz M; Gupta M; Bhatia R Blood; 2004 Apr; 103(8):3167-74. PubMed ID: 15070699 [TBL] [Abstract][Full Text] [Related]
7. Curcumin derivative C817 inhibits proliferation of imatinib-resistant chronic myeloid leukemia cells with wild-type or mutant Bcr-Abl in vitro. Wu LX; Wu Y; Chen RJ; Liu Y; Huang LS; Lou LG; Zheng ZH; Chen YZ; Xu JH Acta Pharmacol Sin; 2014 Mar; 35(3):401-9. PubMed ID: 24487968 [TBL] [Abstract][Full Text] [Related]
8. Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation. Holtz MS; Slovak ML; Zhang F; Sawyers CL; Forman SJ; Bhatia R Blood; 2002 May; 99(10):3792-800. PubMed ID: 11986238 [TBL] [Abstract][Full Text] [Related]
9. Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate. Giuntoli S; Tanturli M; Di Gesualdo F; Barbetti V; Rovida E; Dello Sbarba P Haematologica; 2011 Feb; 96(2):204-12. PubMed ID: 21071498 [TBL] [Abstract][Full Text] [Related]
10. BCR-ABL kinase is dead; long live the CML stem cell. Perl A; Carroll M J Clin Invest; 2011 Jan; 121(1):22-5. PubMed ID: 21157035 [TBL] [Abstract][Full Text] [Related]
11. Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition. Ng KP; Manjeri A; Lee KL; Huang W; Tan SY; Chuah CT; Poellinger L; Ong ST Blood; 2014 May; 123(21):3316-26. PubMed ID: 24705490 [TBL] [Abstract][Full Text] [Related]
12. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies. Jiang X; Zhao Y; Smith C; Gasparetto M; Turhan A; Eaves A; Eaves C Leukemia; 2007 May; 21(5):926-35. PubMed ID: 17330101 [TBL] [Abstract][Full Text] [Related]
13. Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment. Chu S; McDonald T; Lin A; Chakraborty S; Huang Q; Snyder DS; Bhatia R Blood; 2011 Nov; 118(20):5565-72. PubMed ID: 21931114 [TBL] [Abstract][Full Text] [Related]
14. Tetrandrine citrate eliminates imatinib-resistant chronic myeloid leukemia cells in vitro and in vivo by inhibiting Bcr-Abl/β-catenin axis. Xu XH; Gan YC; Xu GB; Chen T; Zhou H; Tang JF; Gu Y; Xu F; Xie YY; Zhao XY; Xu RZ J Zhejiang Univ Sci B; 2012 Nov; 13(11):867-74. PubMed ID: 23125079 [TBL] [Abstract][Full Text] [Related]
15. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Copland M; Hamilton A; Elrick LJ; Baird JW; Allan EK; Jordanides N; Barow M; Mountford JC; Holyoake TL Blood; 2006 Jun; 107(11):4532-9. PubMed ID: 16469872 [TBL] [Abstract][Full Text] [Related]
16. A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia. Ma L; Shan Y; Bai R; Xue L; Eide CA; Ou J; Zhu LJ; Hutchinson L; Cerny J; Khoury HJ; Sheng Z; Druker BJ; Li S; Green MR Sci Transl Med; 2014 Sep; 6(252):252ra121. PubMed ID: 25186176 [TBL] [Abstract][Full Text] [Related]
17. Enhanced ABL-inhibitor-induced MAPK-activation in T315I-BCR-ABL-expressing cells: a potential mechanism of altered leukemogenicity. Härtel N; Klag T; Hanfstein B; Mueller MC; Schenk T; Erben P; Hochhaus A; La Rosée P J Cancer Res Clin Oncol; 2012 Feb; 138(2):203-12. PubMed ID: 22089930 [TBL] [Abstract][Full Text] [Related]
18. Suppression of autophagy by BCR/ABL. Calabretta B; Salomoni P Front Biosci (Schol Ed); 2012 Jan; 4(2):453-60. PubMed ID: 22202070 [TBL] [Abstract][Full Text] [Related]
19. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Bhatia R; Holtz M; Niu N; Gray R; Snyder DS; Sawyers CL; Arber DA; Slovak ML; Forman SJ Blood; 2003 Jun; 101(12):4701-7. PubMed ID: 12576334 [TBL] [Abstract][Full Text] [Related]
20. [A preliminary study on mechanisms for resistance of CML patient BM-derived bcr/abl+ and Flk1+CD31-CD34- stem cells to STI571 in vitro]. Song YP; Fang BJ; Wei XD; Zheng S Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2005 Dec; 13(6):1004-9. PubMed ID: 16403268 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]