These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

94 related articles for article (PubMed ID: 21175429)

  • 1. For a PDK1 inhibitor, the substrate matters.
    Knight ZA
    Biochem J; 2011 Jan; 433(2):e1-2. PubMed ID: 21175429
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.
    Najafov A; Sommer EM; Axten JM; Deyoung MP; Alessi DR
    Biochem J; 2011 Jan; 433(2):357-69. PubMed ID: 21087210
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
    Medina JR; Becker CJ; Blackledge CW; Duquenne C; Feng Y; Grant SW; Heerding D; Li WH; Miller WH; Romeril SP; Scherzer D; Shu A; Bobko MA; Chadderton AR; Dumble M; Gardiner CM; Gilbert S; Liu Q; Rabindran SK; Sudakin V; Xiang H; Brady PG; Campobasso N; Ward P; Axten JM
    J Med Chem; 2011 Mar; 54(6):1871-95. PubMed ID: 21341675
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The phosphoinositide-dependent protein kinase 1 inhibitor, UCN-01, induces fragmentation: possible role of metalloproteinases.
    Alcántara-Hernández R; Hernández-Méndez A; García-Sáinz JA
    Eur J Pharmacol; 2014 Oct; 740():88-96. PubMed ID: 25016091
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors.
    Najafov A; Shpiro N; Alessi DR
    Biochem J; 2012 Dec; 448(2):285-95. PubMed ID: 23030823
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Selective 3-phosphoinositide-dependent kinase 1 (PDK1) inhibitors: dissecting the function and pharmacology of PDK1.
    Medina JR
    J Med Chem; 2013 Apr; 56(7):2726-37. PubMed ID: 23448267
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The calcium-sensing receptor regulates protein tyrosine phosphorylation through PDK1 in boar spermatozoa.
    Macías-García B; García-Marín LJ; Bragado MJ; González-Fernández L
    Mol Reprod Dev; 2019 Jul; 86(7):751-761. PubMed ID: 31074040
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
    Schulze JO; Saladino G; Busschots K; Neimanis S; Süß E; Odadzic D; Zeuzem S; Hindie V; Herbrand AK; Lisa MN; Alzari PM; Gervasio FL; Biondi RM
    Cell Chem Biol; 2016 Oct; 23(10):1193-1205. PubMed ID: 27693059
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1.
    Xu Z; Nagashima K; Sun D; Rush T; Northrup A; Andersen JN; Kariv I; Bobkova EV
    J Biomol Screen; 2009 Dec; 14(10):1257-62. PubMed ID: 19822882
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Small-molecule inhibitors of PDK1.
    Peifer C; Alessi DR
    ChemMedChem; 2008 Dec; 3(12):1810-38. PubMed ID: 18972468
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
    Sturm EM; Parzmair GP; Radnai B; Frei RB; Sturm GJ; Hammer A; Schuligoi R; Lippe IT; Heinemann A
    Eur J Immunol; 2015 May; 45(5):1548-59. PubMed ID: 25645675
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma.
    Scortegagna M; Ruller C; Feng Y; Lazova R; Kluger H; Li JL; De SK; Rickert R; Pellecchia M; Bosenberg M; Ronai ZA
    Oncogene; 2014 Aug; 33(34):4330-9. PubMed ID: 24037523
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site.
    Busschots K; Lopez-Garcia LA; Lammi C; Stroba A; Zeuzem S; Piiper A; Alzari PM; Neimanis S; Arencibia JM; Engel M; Schulze JO; Biondi RM
    Chem Biol; 2012 Sep; 19(9):1152-63. PubMed ID: 22999883
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors.
    Chen T; Sorna V; Choi S; Call L; Bearss J; Carpenter K; Warner SL; Sharma S; Bearss DJ; Vankayalapati H
    Bioorg Med Chem Lett; 2017 Dec; 27(24):5473-5480. PubMed ID: 29150397
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inverse in silico screening for identification of kinase inhibitor targets.
    Zahler S; Tietze S; Totzke F; Kubbutat M; Meijer L; Vollmar AM; Apostolakis J
    Chem Biol; 2007 Nov; 14(11):1207-14. PubMed ID: 18022559
    [TBL] [Abstract][Full Text] [Related]  

  • 16. PDK1 inhibitor GSK2334470 synergizes with proteasome inhibitor MG‑132 in multiple myeloma cells by inhibiting full AKT activity and increasing nuclear accumulation of the PTEN protein.
    Zhang J; Yang C; Zhou F; Chen X
    Oncol Rep; 2018 Jun; 39(6):2951-2959. PubMed ID: 29658600
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays.
    Hofler A; Nichols T; Grant S; Lingardo L; Esposito EA; Gridley S; Murphy ST; Kath JC; Cronin CN; Kraus M; Alton G; Xie Z; Sutton S; Gehring M; Ermolieff J
    Anal Biochem; 2011 Jul; 414(2):179-86. PubMed ID: 21402045
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.
    Feldman RI; Wu JM; Polokoff MA; Kochanny MJ; Dinter H; Zhu D; Biroc SL; Alicke B; Bryant J; Yuan S; Buckman BO; Lentz D; Ferrer M; Whitlow M; Adler M; Finster S; Chang Z; Arnaiz DO
    J Biol Chem; 2005 May; 280(20):19867-74. PubMed ID: 15772071
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Potential inhibition of PDK1/Akt signaling by phenothiazines suppresses cancer cell proliferation and survival.
    Choi JH; Yang YR; Lee SK; Kim SH; Kim YH; Cha JY; Oh SW; Ha JR; Ryu SH; Suh PG
    Ann N Y Acad Sci; 2008 Sep; 1138():393-403. PubMed ID: 18837915
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.
    Nagashima K; Shumway SD; Sathyanarayanan S; Chen AH; Dolinski B; Xu Y; Keilhack H; Nguyen T; Wiznerowicz M; Li L; Lutterbach BA; Chi A; Paweletz C; Allison T; Yan Y; Munshi SK; Klippel A; Kraus M; Bobkova EV; Deshmukh S; Xu Z; Mueller U; Szewczak AA; Pan BS; Richon V; Pollock R; Blume-Jensen P; Northrup A; Andersen JN
    J Biol Chem; 2011 Feb; 286(8):6433-48. PubMed ID: 21118801
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.