252 related articles for article (PubMed ID: 21177334)
1. Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B.
Hashiramoto A; Murata M; Kawazoe T; Yoshida K; Akiyama C; Shiozawa K; Shiozawa S
Rheumatology (Oxford); 2011 May; 50(5):852-61. PubMed ID: 21177334
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
Georgakis GV; Li Y; Rassidakis GZ; Martinez-Valdez H; Medeiros LJ; Younes A
Clin Cancer Res; 2006 Jan; 12(2):584-90. PubMed ID: 16428504
[TBL] [Abstract][Full Text] [Related]
3. Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and phosphatidylinositol 3-kinase/Akt.
Hashiramoto A; Sakai C; Yoshida K; Tsumiyama K; Miura Y; Shiozawa K; Nose M; Komai K; Shiozawa S
Arthritis Rheum; 2007 Jul; 56(7):2170-9. PubMed ID: 17599743
[TBL] [Abstract][Full Text] [Related]
4. Heat shock protein 90 inhibitor induces apoptosis and attenuates activation of hepatic stellate cells.
Myung SJ; Yoon JH; Kim BH; Lee JH; Jung EU; Lee HS
J Pharmacol Exp Ther; 2009 Jul; 330(1):276-82. PubMed ID: 19329756
[TBL] [Abstract][Full Text] [Related]
5. Anti-apoptotic effect of heat shock protein 90 on hypoxia-mediated cardiomyocyte damage is mediated via the phosphatidylinositol 3-kinase/AKT pathway.
Wang W; Peng Y; Wang Y; Zhao X; Yuan Z
Clin Exp Pharmacol Physiol; 2009 Sep; 36(9):899-903. PubMed ID: 19298537
[TBL] [Abstract][Full Text] [Related]
6. Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta-induced cell signaling.
Shi L; Zhang Z; Fang S; Xu J; Liu J; Shen J; Fang F; Luo L; Yin Z
Mol Immunol; 2009 Feb; 46(4):541-50. PubMed ID: 18950863
[TBL] [Abstract][Full Text] [Related]
7. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation.
Jeon YK; Park CH; Kim KY; Li YC; Kim J; Kim YA; Paik JH; Park BK; Kim CW; Kim YN
J Pathol; 2007 Oct; 213(2):170-9. PubMed ID: 17768706
[TBL] [Abstract][Full Text] [Related]
8. Geldanamycin inhibits tyrosine phosphorylation-dependent NF-kappaB activation.
Crèvecoeur J; Merville MP; Piette J; Gloire G
Biochem Pharmacol; 2008 Jun; 75(11):2183-91. PubMed ID: 18455150
[TBL] [Abstract][Full Text] [Related]
9. Necessary role of phosphatidylinositol 3-kinase in transforming growth factor beta-mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts.
Kim G; Jun JB; Elkon KB
Arthritis Rheum; 2002 Jun; 46(6):1504-11. PubMed ID: 12115180
[TBL] [Abstract][Full Text] [Related]
10. Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.
Zhang HG; Wang Y; Xie JF; Liang X; Liu D; Yang P; Hsu HC; Ray RB; Mountz JD
Arthritis Rheum; 2001 Jul; 44(7):1555-67. PubMed ID: 11465707
[TBL] [Abstract][Full Text] [Related]
11. Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.
Xu H; He Y; Yang X; Liang L; Zhan Z; Ye Y; Yang X; Lian F; Sun L
Rheumatology (Oxford); 2007 Jun; 46(6):920-6. PubMed ID: 17314215
[TBL] [Abstract][Full Text] [Related]
12. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways.
Hwang SY; Kim JY; Kim KW; Park MK; Moon Y; Kim WU; Kim HY
Arthritis Res Ther; 2004; 6(2):R120-8. PubMed ID: 15059275
[TBL] [Abstract][Full Text] [Related]
13. Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation.
Machida H; Matsumoto Y; Shirai M; Kubota N
Int J Radiat Biol; 2003 Dec; 79(12):973-80. PubMed ID: 14713575
[TBL] [Abstract][Full Text] [Related]
14. [Study on signal transduction pathway in differentiation and apoptosis of leukemia cells induced by heat shock protein inhibitor].
Yu WJ; Rao Q; Wang M; Tian Z; Xu ZF; Wang JX
Zhonghua Xue Ye Xue Za Zhi; 2007 Oct; 28(10):677-80. PubMed ID: 18399173
[TBL] [Abstract][Full Text] [Related]
15. NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosis.
Bai S; Liu H; Chen KH; Eksarko P; Perlman H; Moore TL; Pope RM
Arthritis Rheum; 2004 Dec; 50(12):3844-55. PubMed ID: 15593196
[TBL] [Abstract][Full Text] [Related]
16. Geldanamycin interferes with the 90-kDa heat shock protein, affecting lipopolysaccharide-mediated interleukin-1 expression and apoptosis within macrophages.
Hsu HY; Wu HL; Tan SK; Li VP; Wang WT; Hsu J; Cheng CH
Mol Pharmacol; 2007 Jan; 71(1):344-56. PubMed ID: 16868182
[TBL] [Abstract][Full Text] [Related]
17. Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells.
Schumacher JA; Crockett DK; Elenitoba-Johnson KS; Lim MS
Proteomics; 2007 Aug; 7(15):2603-16. PubMed ID: 17610208
[TBL] [Abstract][Full Text] [Related]
18. Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis.
Harigai M; Hara M; Kawamoto M; Kawaguchi Y; Sugiura T; Tanaka M; Nakagawa M; Ichida H; Takagi K; Higami-Ohsako S; Shimada K; Kamatani N
Arthritis Rheum; 2004 Jul; 50(7):2167-77. PubMed ID: 15248214
[TBL] [Abstract][Full Text] [Related]
19. [Heat shock activated Rac-MEKK-JNK pathway and hsp90 beta gene expression].
Li XY; Lu C; Wu NH; Shen YF
Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2002 Jun; 24(3):264-8. PubMed ID: 12905631
[TBL] [Abstract][Full Text] [Related]
20. Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.
Takada Y; Ichikawa H; Pataer A; Swisher S; Aggarwal BB
Oncogene; 2007 Feb; 26(8):1201-12. PubMed ID: 16924232
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]