336 related articles for article (PubMed ID: 21177487)
1. In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite.
Mahajan MK; Uttamsingh V; Daniels JS; Gan LS; LeDuc BW; Williams DA
Drug Metab Dispos; 2011 Apr; 39(4):693-702. PubMed ID: 21177487
[TBL] [Abstract][Full Text] [Related]
2. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
[TBL] [Abstract][Full Text] [Related]
3. Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism.
Wu WN; McKown LA; Reitz AB
Eur J Drug Metab Pharmacokinet; 2006; 31(4):277-83. PubMed ID: 17315539
[TBL] [Abstract][Full Text] [Related]
4. In vitro metabolism studies of nomifensine monooxygenation pathways: metabolite identification, reaction phenotyping, and bioactivation mechanism.
Yu J; Brown DG; Burdette D
Drug Metab Dispos; 2010 Oct; 38(10):1767-78. PubMed ID: 20595377
[TBL] [Abstract][Full Text] [Related]
5. Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats.
Jin L; Baillie TA
Chem Res Toxicol; 1997 Mar; 10(3):318-27. PubMed ID: 9084912
[TBL] [Abstract][Full Text] [Related]
6. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
Reilly CA; Ehlhardt WJ; Jackson DA; Kulanthaivel P; Mutlib AE; Espina RJ; Moody DE; Crouch DJ; Yost GS
Chem Res Toxicol; 2003 Mar; 16(3):336-49. PubMed ID: 12641434
[TBL] [Abstract][Full Text] [Related]
7. In vitro metabolism of BIIB021, an inhibitor of heat shock protein 90, in liver microsomes and hepatocytes of rats, dogs, and humans and recombinant human cytochrome P450 isoforms.
Xu L; Woodward C; Khan S; Prakash C
Drug Metab Dispos; 2012 Apr; 40(4):680-93. PubMed ID: 22217465
[TBL] [Abstract][Full Text] [Related]
8. Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes.
Kang P; Dalvie D; Smith E; Zhou S; Deese A
Drug Metab Dispos; 2007 Jul; 35(7):1081-8. PubMed ID: 17403914
[TBL] [Abstract][Full Text] [Related]
9. Disposition of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2'- (methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by novel metabolic pathways. Characterization of unusual metabolites by liquid chromatography/mass spectrometry and NMR.
Mutlib AE; Shockcor J; Chen SY; Espina RJ; Pinto DJ; Orwat MJ; Prakash SR; Gan LS
Chem Res Toxicol; 2002 Jan; 15(1):48-62. PubMed ID: 11800597
[TBL] [Abstract][Full Text] [Related]
10. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
Tang W; Stearns RA; Wang RW; Chiu SH; Baillie TA
Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
[TBL] [Abstract][Full Text] [Related]
11. Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine.
Wen B; Ma L; Rodrigues AD; Zhu M
Drug Metab Dispos; 2008 May; 36(5):841-50. PubMed ID: 18238857
[TBL] [Abstract][Full Text] [Related]
12. In vitro metabolism of obovatol and its effect on cytochrome P450 enzyme activities in human liver microsomes.
Joo J; Lee D; Wu Z; Shin JH; Lee HS; Kwon BM; Huh TL; Kim YW; Lee SJ; Kim TW; Lee T; Liu KH
Biopharm Drug Dispos; 2013 May; 34(4):195-202. PubMed ID: 23446989
[TBL] [Abstract][Full Text] [Related]
13. Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.
Wen B; Chen Y; Fitch WL
Drug Metab Dispos; 2009 Jul; 37(7):1557-62. PubMed ID: 19364830
[TBL] [Abstract][Full Text] [Related]
14. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
[TBL] [Abstract][Full Text] [Related]
15. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
[TBL] [Abstract][Full Text] [Related]
16. Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: characterization of thioether conjugates by liquid chromatography/mass spectrometry and high field nuclear magnetic resonance spectroscopy.
Chen H; Grover S; Yu L; Walker G; Mutlib A
Chem Res Toxicol; 2010 Jan; 23(1):159-70. PubMed ID: 19961160
[TBL] [Abstract][Full Text] [Related]
17. Bioactivation of glafenine by human liver microsomes and peroxidases: identification of electrophilic iminoquinone species and GSH conjugates.
Wen B; Moore DJ
Drug Metab Dispos; 2011 Sep; 39(9):1511-21. PubMed ID: 21628497
[TBL] [Abstract][Full Text] [Related]
18. In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity.
Smith KS; Smith PL; Heady TN; Trugman JM; Harman WD; Macdonald TL
Chem Res Toxicol; 2003 Feb; 16(2):123-8. PubMed ID: 12588182
[TBL] [Abstract][Full Text] [Related]
19. Evidence for the bioactivation of 4-nonylphenol to quinone methide and ortho-benzoquinone metabolites in human liver microsomes.
Deng P; Zhong D; Nan F; Liu S; Li D; Yuan T; Chen X; Zheng J
Chem Res Toxicol; 2010 Oct; 23(10):1617-28. PubMed ID: 20843008
[TBL] [Abstract][Full Text] [Related]
20. In Vitro and In Vivo Characterization of Reactive Intermediates of Corynoline.
Mao X; Peng Y; Zheng J
Drug Metab Dispos; 2015 Oct; 43(10):1491-8. PubMed ID: 26261285
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
