BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

195 related articles for article (PubMed ID: 21193062)

  • 1. A novel mechanism for LQT3 with 2:1 block: a pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation.
    Horne AJ; Eldstrom J; Sanatani S; Fedida D
    Heart Rhythm; 2011 May; 8(5):770-7. PubMed ID: 21193062
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In utero onset of long QT syndrome with atrioventricular block and spontaneous or lidocaine-induced ventricular tachycardia: compound effects of hERG pore region mutation and SCN5A N-terminus variant.
    Lin MT; Wu MH; Chang CC; Chiu SN; Thériault O; Huang H; Christé G; Ficker E; Chahine M
    Heart Rhythm; 2008 Nov; 5(11):1567-74. PubMed ID: 18848812
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Gating properties of SCN5A mutations and the response to mexiletine in long-QT syndrome type 3 patients.
    Ruan Y; Liu N; Bloise R; Napolitano C; Priori SG
    Circulation; 2007 Sep; 116(10):1137-44. PubMed ID: 17698727
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A novel mutation in SCN5A, delQKP 1507-1509, causing long QT syndrome: role of Q1507 residue in sodium channel inactivation.
    Keller DI; Acharfi S; Delacrétaz E; Benammar N; Rotter M; Pfammatter JP; Fressart V; Guicheney P; Chahine M
    J Mol Cell Cardiol; 2003 Dec; 35(12):1513-21. PubMed ID: 14654377
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating.
    Wehrens XH; Rossenbacker T; Jongbloed RJ; Gewillig M; Heidbüchel H; Doevendans PA; Vos MA; Wellens HJ; Kass RS
    Hum Mutat; 2003 May; 21(5):552. PubMed ID: 12673799
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel.
    Abriel H; Cabo C; Wehrens XH; Rivolta I; Motoike HK; Memmi M; Napolitano C; Priori SG; Kass RS
    Circ Res; 2001 Apr; 88(7):740-5. PubMed ID: 11304498
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes.
    Viswanathan PC; Bezzina CR; George AL; Roden DM; Wilde AA; Balser JR
    Circulation; 2001 Sep; 104(10):1200-5. PubMed ID: 11535580
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Malignant perinatal variant of long-QT syndrome caused by a profoundly dysfunctional cardiac sodium channel.
    Wang DW; Crotti L; Shimizu W; Pedrazzini M; Cantu F; De Filippo P; Kishiki K; Miyazaki A; Ikeda T; Schwartz PJ; George AL
    Circ Arrhythm Electrophysiol; 2008 Dec; 1(5):370-8. PubMed ID: 19808432
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A distinct molecular mechanism by which phenytoin rescues a novel long QT 3 variant.
    Gando I; Campana C; Tan RB; Cecchin F; Sobie EA; Coetzee WA
    J Mol Cell Cardiol; 2020 Jul; 144():1-11. PubMed ID: 32339567
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A sodium channel pore mutation causing Brugada syndrome.
    Pfahnl AE; Viswanathan PC; Weiss R; Shang LL; Sanyal S; Shusterman V; Kornblit C; London B; Dudley SC
    Heart Rhythm; 2007 Jan; 4(1):46-53. PubMed ID: 17198989
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.
    Blana A; Kaese S; Fortmüller L; Laakmann S; Damke D; van Bragt K; Eckstein J; Piccini I; Kirchhefer U; Nattel S; Breithardt G; Carmeliet P; Carmeliet E; Schotten U; Verheule S; Kirchhof P; Fabritz L
    Heart Rhythm; 2010 Dec; 7(12):1862-9. PubMed ID: 20728579
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Functional characterization and identification of a therapeutic for a novel SCN5A-F1760C variant causing type 3 long QT syndrome refractory to all guideline-directed therapies.
    Stutzman MJ; Gao X; Kim M; Ye D; Zhou W; Tester DJ; Giudicessi JR; Shannon K; Ackerman MJ
    Heart Rhythm; 2023 May; 20(5):709-717. PubMed ID: 36731785
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Complex interactions in a novel SCN5A compound mutation associated with long QT and Brugada syndrome: Implications for Na+ channel blocking pharmacotherapy for de novo conduction disease.
    Liu J; Bayer JD; Aschar-Sobbi R; Wauchop M; Spears D; Gollob M; Vigmond EJ; Tsushima R; Backx PH; Chauhan VS
    PLoS One; 2018; 13(5):e0197273. PubMed ID: 29791480
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Normalization of ventricular repolarization with flecainide in long QT syndrome patients with SCN5A:DeltaKPQ mutation.
    Windle JR; Geletka RC; Moss AJ; Zareba W; Atkins DL
    Ann Noninvasive Electrocardiol; 2001 Apr; 6(2):153-8. PubMed ID: 11333173
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo.
    Tian XL; Yong SL; Wan X; Wu L; Chung MK; Tchou PJ; Rosenbaum DS; Van Wagoner DR; Kirsch GE; Wang Q
    Cardiovasc Res; 2004 Feb; 61(2):256-67. PubMed ID: 14736542
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A novel LQT3 mutation implicates the human cardiac sodium channel domain IVS6 in inactivation kinetics.
    Groenewegen WA; Bezzina CR; van Tintelen JP; Hoorntje TM; Mannens MM; Wilde AA; Jongsma HJ; Rook MB
    Cardiovasc Res; 2003 Mar; 57(4):1072-8. PubMed ID: 12650885
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome.
    Wang DW; Yazawa K; George AL; Bennett PB
    Proc Natl Acad Sci U S A; 1996 Nov; 93(23):13200-5. PubMed ID: 8917568
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Look beyond the hERG mutation: a neutral SCN5A variant may turn lidocaine into a threat.
    Lindegger N; Mongillo M
    Heart Rhythm; 2008 Nov; 5(11):1575-6. PubMed ID: 18984535
    [No Abstract]   [Full Text] [Related]  

  • 19. Congenital long-QT syndrome caused by a novel mutation in a conserved acidic domain of the cardiac Na+ channel.
    Wei J; Wang DW; Alings M; Fish F; Wathen M; Roden DM; George AL
    Circulation; 1999 Jun; 99(24):3165-71. PubMed ID: 10377081
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.
    Potet F; Beckermann TM; Kunic JD; George AL
    Circ Arrhythm Electrophysiol; 2015 Aug; 8(4):933-41. PubMed ID: 26022185
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.