These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

237 related articles for article (PubMed ID: 21206757)

  • 1. Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.
    Jayadev S; Case A; Eastman AJ; Nguyen H; Pollak J; Wiley JC; Möller T; Morrison RS; Garden GA
    PLoS One; 2010 Dec; 5(12):e15743. PubMed ID: 21206757
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
    Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlström H; Kienlen-Campard P
    J Cell Mol Med; 2018 Feb; 22(2):823-833. PubMed ID: 28994238
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
    Pintchovski SA; Schenk DB; Basi GS
    Curr Alzheimer Res; 2013 Jan; 10(1):4-10. PubMed ID: 22950863
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
    Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
    J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase.
    Eccles MK; Main N; Carlessi R; Armstrong AM; Sabale M; Roberts-Mok B; Tirnitz-Parker JEE; Agostino M; Groth D; Fraser PE; Verdile G
    FASEB J; 2024 Jan; 38(1):e23396. PubMed ID: 38156414
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
    Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
    Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
    Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
    Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
    Watanabe H; Imaizumi K; Cai T; Zhou Z; Tomita T; Okano H
    eNeuro; 2021; 8(2):. PubMed ID: 33608391
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
    Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
    Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
    Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
    J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
    Fukumori A; Fluhrer R; Steiner H; Haass C
    J Neurosci; 2010 Jun; 30(23):7853-62. PubMed ID: 20534834
    [TBL] [Abstract][Full Text] [Related]  

  • 12. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
    Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
    J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
    Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ
    J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Acceleration of amyloidogenesis and memory impairment by estrogen deficiency through NF-κB dependent beta-secretase activation in presenilin 2 mutant mice.
    Hwang CJ; Park MH; Choi MK; Choi JS; Oh KW; Hwang DY; Han SB; Hong JT
    Brain Behav Immun; 2016 Mar; 53():113-122. PubMed ID: 26593275
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
    Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.
    Lai MT; Chen E; Crouthamel MC; DiMuzio-Mower J; Xu M; Huang Q; Price E; Register RB; Shi XP; Donoviel DB; Bernstein A; Hazuda D; Gardell SJ; Li YM
    J Biol Chem; 2003 Jun; 278(25):22475-81. PubMed ID: 12684521
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.
    Marinangeli C; Tasiaux B; Opsomer R; Hage S; Sodero AO; Dewachter I; Octave JN; Smith SO; Constantinescu SN; Kienlen-Campard P
    J Biol Chem; 2015 Mar; 290(11):7169-84. PubMed ID: 25614624
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice.
    Chu Y; Peng X; Long Z; Wang K; Luo S; Sharma A; He G
    Acta Biochim Biophys Sin (Shanghai); 2015 Apr; 47(4):258-66. PubMed ID: 25736404
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
    Page RM; Baumann K; Tomioka M; Pérez-Revuelta BI; Fukumori A; Jacobsen H; Flohr A; Luebbers T; Ozmen L; Steiner H; Haass C
    J Biol Chem; 2008 Jan; 283(2):677-83. PubMed ID: 17962197
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.