238 related articles for article (PubMed ID: 21206757)
1. Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.
Jayadev S; Case A; Eastman AJ; Nguyen H; Pollak J; Wiley JC; Möller T; Morrison RS; Garden GA
PLoS One; 2010 Dec; 5(12):e15743. PubMed ID: 21206757
[TBL] [Abstract][Full Text] [Related]
2. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlström H; Kienlen-Campard P
J Cell Mol Med; 2018 Feb; 22(2):823-833. PubMed ID: 28994238
[TBL] [Abstract][Full Text] [Related]
3. Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
Pintchovski SA; Schenk DB; Basi GS
Curr Alzheimer Res; 2013 Jan; 10(1):4-10. PubMed ID: 22950863
[TBL] [Abstract][Full Text] [Related]
4. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
[TBL] [Abstract][Full Text] [Related]
5. Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase.
Eccles MK; Main N; Carlessi R; Armstrong AM; Sabale M; Roberts-Mok B; Tirnitz-Parker JEE; Agostino M; Groth D; Fraser PE; Verdile G
FASEB J; 2024 Jan; 38(1):e23396. PubMed ID: 38156414
[TBL] [Abstract][Full Text] [Related]
6. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
[TBL] [Abstract][Full Text] [Related]
7. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
[TBL] [Abstract][Full Text] [Related]
8. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
Watanabe H; Imaizumi K; Cai T; Zhou Z; Tomita T; Okano H
eNeuro; 2021; 8(2):. PubMed ID: 33608391
[TBL] [Abstract][Full Text] [Related]
9. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
[TBL] [Abstract][Full Text] [Related]
10. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
[TBL] [Abstract][Full Text] [Related]
11. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
Fukumori A; Fluhrer R; Steiner H; Haass C
J Neurosci; 2010 Jun; 30(23):7853-62. PubMed ID: 20534834
[TBL] [Abstract][Full Text] [Related]
12. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
[TBL] [Abstract][Full Text] [Related]
13. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
[TBL] [Abstract][Full Text] [Related]
14. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ
J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302
[TBL] [Abstract][Full Text] [Related]
15. Acceleration of amyloidogenesis and memory impairment by estrogen deficiency through NF-κB dependent beta-secretase activation in presenilin 2 mutant mice.
Hwang CJ; Park MH; Choi MK; Choi JS; Oh KW; Hwang DY; Han SB; Hong JT
Brain Behav Immun; 2016 Mar; 53():113-122. PubMed ID: 26593275
[TBL] [Abstract][Full Text] [Related]
16. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
[TBL] [Abstract][Full Text] [Related]
17. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.
Lai MT; Chen E; Crouthamel MC; DiMuzio-Mower J; Xu M; Huang Q; Price E; Register RB; Shi XP; Donoviel DB; Bernstein A; Hazuda D; Gardell SJ; Li YM
J Biol Chem; 2003 Jun; 278(25):22475-81. PubMed ID: 12684521
[TBL] [Abstract][Full Text] [Related]
18. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.
Marinangeli C; Tasiaux B; Opsomer R; Hage S; Sodero AO; Dewachter I; Octave JN; Smith SO; Constantinescu SN; Kienlen-Campard P
J Biol Chem; 2015 Mar; 290(11):7169-84. PubMed ID: 25614624
[TBL] [Abstract][Full Text] [Related]
19. Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice.
Chu Y; Peng X; Long Z; Wang K; Luo S; Sharma A; He G
Acta Biochim Biophys Sin (Shanghai); 2015 Apr; 47(4):258-66. PubMed ID: 25736404
[TBL] [Abstract][Full Text] [Related]
20. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
Page RM; Baumann K; Tomioka M; Pérez-Revuelta BI; Fukumori A; Jacobsen H; Flohr A; Luebbers T; Ozmen L; Steiner H; Haass C
J Biol Chem; 2008 Jan; 283(2):677-83. PubMed ID: 17962197
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
