298 related articles for article (PubMed ID: 21210745)
1. Bioactivation of drugs: risk and drug design.
Walsh JS; Miwa GT
Annu Rev Pharmacol Toxicol; 2011; 51():145-67. PubMed ID: 21210745
[TBL] [Abstract][Full Text] [Related]
2. Biotransformation and bioactivation reactions of alicyclic amines in drug molecules.
Bolleddula J; DeMent K; Driscoll JP; Worboys P; Brassil PJ; Bourdet DL
Drug Metab Rev; 2014 Aug; 46(3):379-419. PubMed ID: 24909234
[TBL] [Abstract][Full Text] [Related]
3. Peroxidases: a role in the metabolism and side effects of drugs.
Tafazoli S; O'Brien PJ
Drug Discov Today; 2005 May; 10(9):617-25. PubMed ID: 15894226
[TBL] [Abstract][Full Text] [Related]
4. Predicting toxicities of reactive metabolite-positive drug candidates.
Kalgutkar AS; Dalvie D
Annu Rev Pharmacol Toxicol; 2015; 55():35-54. PubMed ID: 25292426
[TBL] [Abstract][Full Text] [Related]
5. Non-cytochrome P450-mediated bioactivation and its toxicological relevance.
Gan J; Ma S; Zhang D
Drug Metab Rev; 2016 Nov; 48(4):473-501. PubMed ID: 27533622
[TBL] [Abstract][Full Text] [Related]
6. Cytochrome P450s and other enzymes in drug metabolism and toxicity.
Guengerich FP
AAPS J; 2006 Mar; 8(1):E101-11. PubMed ID: 16584116
[TBL] [Abstract][Full Text] [Related]
7. Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.
Stepan AF; Walker DP; Bauman J; Price DA; Baillie TA; Kalgutkar AS; Aleo MD
Chem Res Toxicol; 2011 Sep; 24(9):1345-410. PubMed ID: 21702456
[TBL] [Abstract][Full Text] [Related]
8. The generation, detection, and effects of reactive drug metabolites.
Stachulski AV; Baillie TA; Park BK; Obach RS; Dalvie DK; Williams DP; Srivastava A; Regan SL; Antoine DJ; Goldring CE; Chia AJ; Kitteringham NR; Randle LE; Callan H; Castrejon JL; Farrell J; Naisbitt DJ; Lennard MS
Med Res Rev; 2013 Sep; 33(5):985-1080. PubMed ID: 23090860
[TBL] [Abstract][Full Text] [Related]
9. Cytochrome P450s: mechanisms and biological implications in drug metabolism and its interaction with oxidative stress.
Bhattacharyya S; Sinha K; Sil PC
Curr Drug Metab; 2014; 15(7):719-42. PubMed ID: 25429675
[TBL] [Abstract][Full Text] [Related]
10. Minimising the potential for metabolic activation in drug discovery.
Kalgutkar AS; Soglia JR
Expert Opin Drug Metab Toxicol; 2005 Jun; 1(1):91-142. PubMed ID: 16922655
[TBL] [Abstract][Full Text] [Related]
11. Detecting reactive drug metabolites for reducing the potential for drug toxicity.
Grillo MP
Expert Opin Drug Metab Toxicol; 2015; 11(8):1281-302. PubMed ID: 26005795
[TBL] [Abstract][Full Text] [Related]
12. On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics.
Kalgutkar AS; Dalvie DK; O'Donnell JP; Taylor TJ; Sahakian DC
Curr Drug Metab; 2002 Aug; 3(4):379-424. PubMed ID: 12093357
[TBL] [Abstract][Full Text] [Related]
13. Drug bioactivation and protein adduct formation in the pathogenesis of drug-induced toxicity.
Park BK; Laverty H; Srivastava A; Antoine DJ; Naisbitt D; Williams DP
Chem Biol Interact; 2011 Jun; 192(1-2):30-6. PubMed ID: 20846520
[TBL] [Abstract][Full Text] [Related]
14. A comprehensive listing of bioactivation pathways of organic functional groups.
Kalgutkar AS; Gardner I; Obach RS; Shaffer CL; Callegari E; Henne KR; Mutlib AE; Dalvie DK; Lee JS; Nakai Y; O'Donnell JP; Boer J; Harriman SP
Curr Drug Metab; 2005 Jun; 6(3):161-225. PubMed ID: 15975040
[TBL] [Abstract][Full Text] [Related]
15. Managing the liabilities arising from structural alerts: a safe philosophy for medicinal chemists.
Edwards PJ; Sturino C
Curr Med Chem; 2011; 18(20):3116-35. PubMed ID: 21651480
[TBL] [Abstract][Full Text] [Related]
16. Role of bioactivation in drug-induced hypersensitivity reactions.
Sanderson JP; Naisbitt DJ; Park BK
AAPS J; 2006 Feb; 8(1):E55-64. PubMed ID: 16584134
[TBL] [Abstract][Full Text] [Related]
17. Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism.
Pirmohamed M; Madden S; Park BK
Clin Pharmacokinet; 1996 Sep; 31(3):215-30. PubMed ID: 8877251
[TBL] [Abstract][Full Text] [Related]
18. Metabolic activation in drug-induced liver injury.
Leung L; Kalgutkar AS; Obach RS
Drug Metab Rev; 2012 Feb; 44(1):18-33. PubMed ID: 21939431
[TBL] [Abstract][Full Text] [Related]
19. Cytochromes P450 in the bioactivation of chemicals.
Ioannides C; Lewis DF
Curr Top Med Chem; 2004; 4(16):1767-88. PubMed ID: 15579107
[TBL] [Abstract][Full Text] [Related]
20. Are chemically reactive metabolites responsible for adverse reactions to drugs?
Williams DP; Kitteringham NR; Naisbitt DJ; Pirmohamed M; Smith DA; Park BK
Curr Drug Metab; 2002 Aug; 3(4):351-66. PubMed ID: 12093355
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
