BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

361 related articles for article (PubMed ID: 21216930)

  • 1. JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling.
    Song L; Rawal B; Nemeth JA; Haura EB
    Mol Cancer Ther; 2011 Mar; 10(3):481-94. PubMed ID: 21216930
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutation.
    Kim SM; Kwon OJ; Hong YK; Kim JH; Solca F; Ha SJ; Soo RA; Christensen JG; Lee JH; Cho BC
    Mol Cancer Ther; 2012 Oct; 11(10):2254-64. PubMed ID: 22891040
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.
    Chen J; Zhang Y; Petrus MN; Xiao W; Nicolae A; Raffeld M; Pittaluga S; Bamford RN; Nakagawa M; Ouyang ST; Epstein AL; Kadin ME; Del Mistro A; Woessner R; Jaffe ES; Waldmann TA
    Proc Natl Acad Sci U S A; 2017 Apr; 114(15):3975-3980. PubMed ID: 28356514
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer.
    Song L; Smith MA; Doshi P; Sasser K; Fulp W; Altiok S; Haura EB
    J Thorac Oncol; 2014 Jul; 9(7):974-982. PubMed ID: 24922005
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.
    Gao SP; Mark KG; Leslie K; Pao W; Motoi N; Gerald WL; Travis WD; Bornmann W; Veach D; Clarkson B; Bromberg JF
    J Clin Invest; 2007 Dec; 117(12):3846-56. PubMed ID: 18060032
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells.
    Cao W; Liu Y; Zhang R; Zhang B; Wang T; Zhu X; Mei L; Chen H; Zhang H; Ming P; Huang L
    Sci Rep; 2015 Jul; 5():8477. PubMed ID: 26166037
    [TBL] [Abstract][Full Text] [Related]  

  • 7. EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma.
    Clay TD; Russell PA; Do H; Sundararajan V; Conron M; Wright GM; Solomon B; Dobrovic A; McLachlan SA; Moore MM
    Med Oncol; 2017 Sep; 34(10):175. PubMed ID: 28879441
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of JAK1/2 can overcome EGFR-TKI resistance in human NSCLC.
    Kim DM; Kim MJ; Moon JH; Lee EY; Hong JK; Lee S; Koh DI; Ryu YS; Kim SM; Jung SA; Shin JS; Kim J; Park YS; Hong SW; Lee SH; Jung J; Park SS; Kim DY; Kim EH; Jeong HR; Gong JH; Kim J; Chan Kim S; Yu HN; Ki SY; Kim TW; Jin DH
    Biochem Biophys Res Commun; 2020 Jun; 527(1):305-310. PubMed ID: 32446385
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3.
    Shou J; You L; Yao J; Xie J; Jing J; Jing Z; Jiang L; Sui X; Pan H; Han W
    Cancer Lett; 2016 Aug; 379(1):124-33. PubMed ID: 27264264
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.
    Subramaniam A; Shanmugam MK; Ong TH; Li F; Perumal E; Chen L; Vali S; Abbasi T; Kapoor S; Ahn KS; Kumar AP; Hui KM; Sethi G
    Br J Pharmacol; 2013 Oct; 170(4):807-21. PubMed ID: 23848338
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Interleukin-6 promotes proliferative vitreoretinopathy by inducing epithelial-mesenchymal transition via the JAK1/STAT3 signaling pathway.
    Chen X; Yang W; Deng X; Ye S; Xiao W
    Mol Vis; 2020; 26():517-529. PubMed ID: 32818015
    [TBL] [Abstract][Full Text] [Related]  

  • 12. ILT4 inhibition prevents TAM- and dysfunctional T cell-mediated immunosuppression and enhances the efficacy of anti-PD-L1 therapy in NSCLC with EGFR activation.
    Chen X; Gao A; Zhang F; Yang Z; Wang S; Fang Y; Li J; Wang J; Shi W; Wang L; Zheng Y; Sun Y
    Theranostics; 2021; 11(7):3392-3416. PubMed ID: 33537094
    [No Abstract]   [Full Text] [Related]  

  • 13. Oral administration of penta-O-galloyl-β-D-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition.
    Lee HJ; Seo NJ; Jeong SJ; Park Y; Jung DB; Koh W; Lee HJ; Lee EO; Ahn KS; Ahn KS; Lü J; Kim SH
    Carcinogenesis; 2011 Jun; 32(6):804-11. PubMed ID: 21289371
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cooperative interaction between protein inhibitor of activated signal transducer and activator of transcription-3 with epidermal growth factor receptor blockade in lung cancer.
    Kluge A; Dabir S; Kern J; Nethery D; Halmos B; Ma P; Dowlati A
    Int J Cancer; 2009 Oct; 125(7):1728-34. PubMed ID: 19569236
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas.
    Lee TL; Yeh J; Van Waes C; Chen Z
    Mol Cancer Ther; 2006 Jan; 5(1):8-19. PubMed ID: 16432158
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma.
    Yang S; Luo C; Gu Q; Xu Q; Wang G; Sun H; Qian Z; Tan Y; Qin Y; Shen Y; Xu X; Chen SH; Chan CC; Wang H; Mao M; Fang DD
    Oncotarget; 2016 Feb; 7(5):5461-9. PubMed ID: 26701727
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Induction of apoptosis by morusin in human non-small cell lung cancer cells by suppression of EGFR/STAT3 activation.
    Park HJ; Min TR; Chi GY; Choi YH; Park SH
    Biochem Biophys Res Commun; 2018 Oct; 505(1):194-200. PubMed ID: 30243717
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway.
    Kuang Y; Guo W; Ling J; Xu D; Liao Y; Zhao H; Du X; Wang H; Xu M; Song H; Wang T; Jing B; Li K; Hu M; Wu W; Deng J; Wang Q
    Cell Death Dis; 2019 Apr; 10(4):297. PubMed ID: 30931929
    [TBL] [Abstract][Full Text] [Related]  

  • 19. LIF-JAK1-STAT3 signaling delays contact inhibition of human corneal endothelial cells.
    Liu X; Tseng SC; Zhang MC; Chen SY; Tighe S; Lu WJ; Zhu YT
    Cell Cycle; 2015; 14(8):1197-206. PubMed ID: 25695744
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC.
    Chaib I; Karachaliou N; Pilotto S; Codony Servat J; Cai X; Li X; Drozdowskyj A; Servat CC; Yang J; Hu C; Cardona AF; Vivanco GL; Vergnenegre A; Sanchez JM; Provencio M; de Marinis F; Passaro A; Carcereny E; Reguart N; Campelo CG; Teixido C; Sperduti I; Rodriguez S; Lazzari C; Verlicchi A; de Aguirre I; Queralt C; Wei J; Estrada R; Puig de la Bellacasa R; Ramirez JL; Jacobson K; Ditzel HJ; Santarpia M; Viteri S; Molina MA; Zhou C; Cao P; Ma PC; Bivona TG; Rosell R
    J Natl Cancer Inst; 2017 Sep; 109(9):. PubMed ID: 28376152
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.