These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

146 related articles for article (PubMed ID: 21222447)

  • 1. Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolase.
    Johnson CM; Linsky TW; Yoon DW; Person MD; Fast W
    J Am Chem Soc; 2011 Feb; 133(5):1553-62. PubMed ID: 21222447
    [TBL] [Abstract][Full Text] [Related]  

  • 2. On the mechanism of dimethylarginine dimethylaminohydrolase inactivation by 4-halopyridines.
    Johnson CM; Monzingo AF; Ke Z; Yoon DW; Linsky TW; Guo H; Robertus JD; Fast W
    J Am Chem Soc; 2011 Jul; 133(28):10951-9. PubMed ID: 21630706
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selective Covalent Protein Modification by 4-Halopyridines through Catalysis.
    Schardon CL; Tuley A; Er JAV; Swartzel JC; Fast W
    Chembiochem; 2017 Aug; 18(15):1551-1556. PubMed ID: 28470883
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of 4,4'-Dipyridylsulfide Analogs as "Switchable Electrophiles" for Covalent Inhibition.
    Ahn YC; May VK; Bedford GC; Tuley AA; Fast W
    ACS Chem Biol; 2021 Feb; 16(2):264-269. PubMed ID: 33492128
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
    Linsky TW; Fast W
    Bioorg Med Chem; 2012 Sep; 20(18):5550-8. PubMed ID: 22921743
    [TBL] [Abstract][Full Text] [Related]  

  • 6. S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase.
    Leiper J; Murray-Rust J; McDonald N; Vallance P
    Proc Natl Acad Sci U S A; 2002 Oct; 99(21):13527-32. PubMed ID: 12370443
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa.
    Stone EM; Costello AL; Tierney DL; Fast W
    Biochemistry; 2006 May; 45(17):5618-30. PubMed ID: 16634643
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase.
    Stone EM; Schaller TH; Bianchi H; Person MD; Fast W
    Biochemistry; 2005 Oct; 44(42):13744-52. PubMed ID: 16229464
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1.
    Tommasi S; Zanato C; Lewis BC; Nair PC; Dall'Angelo S; Zanda M; Mangoni AA
    Org Biomol Chem; 2015 Dec; 13(46):11315-30. PubMed ID: 26420019
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of
    Lunk I; Litty FA; Hennig S; Vetter IR; Kotthaus J; Altmann KS; Ott G; Havemeyer A; Carrillo GarcĂ­a C; Clement B; Schade D
    J Med Chem; 2020 Jan; 63(1):425-432. PubMed ID: 31841335
    [No Abstract]   [Full Text] [Related]  

  • 11. Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis.
    Hartzoulakis B; Rossiter S; Gill H; O'Hara B; Steinke E; Gane PJ; Hurtado-Guerrero R; Leiper JM; Vallance P; Rust JM; Selwood DL
    Bioorg Med Chem Lett; 2007 Jul; 17(14):3953-6. PubMed ID: 17543521
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis.
    Stone EM; Person MD; Costello NJ; Fast W
    Biochemistry; 2005 May; 44(18):7069-78. PubMed ID: 15865451
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.
    Mileni M; Garfunkle J; DeMartino JK; Cravatt BF; Boger DL; Stevens RC
    J Am Chem Soc; 2009 Aug; 131(30):10497-506. PubMed ID: 19722626
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.
    Wang Y; Monzingo AF; Hu S; Schaller TH; Robertus JD; Fast W
    Biochemistry; 2009 Sep; 48(36):8624-35. PubMed ID: 19663506
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A continuous, fluorescent, high-throughput assay for human dimethylarginine dimethylaminohydrolase-1.
    Linsky T; Fast W
    J Biomol Screen; 2011 Oct; 16(9):1089-97. PubMed ID: 21921133
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase.
    Kotthaus J; Schade D; Kotthaus J; Clement B
    J Enzyme Inhib Med Chem; 2012 Feb; 27(1):24-8. PubMed ID: 21740101
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
    Hong L; Fast W
    J Biol Chem; 2007 Nov; 282(48):34684-92. PubMed ID: 17895252
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural characterization and high-throughput screening of inhibitors of PvdQ, an NTN hydrolase involved in pyoverdine synthesis.
    Drake EJ; Gulick AM
    ACS Chem Biol; 2011 Nov; 6(11):1277-86. PubMed ID: 21892836
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development.
    Murphy RB; Tommasi S; Lewis BC; Mangoni AA
    Molecules; 2016 May; 21(5):. PubMed ID: 27187323
    [TBL] [Abstract][Full Text] [Related]  

  • 20. DdaR (PA1196) Regulates Expression of Dimethylarginine Dimethylaminohydrolase for the Metabolism of Methylarginines in Pseudomonas aeruginosa PAO1.
    Lundgren BR; Bailey FJ; Moley G; Nomura CT
    J Bacteriol; 2017 Apr; 199(8):. PubMed ID: 28167521
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.