253 related articles for article (PubMed ID: 21222484)
1. Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.
Grogan BC; Parker JB; Guminski AF; Stivers JT
Biochemistry; 2011 Feb; 50(5):618-27. PubMed ID: 21222484
[TBL] [Abstract][Full Text] [Related]
2. Dynamics of uracil and 5-fluorouracil in DNA.
Parker JB; Stivers JT
Biochemistry; 2011 Feb; 50(5):612-7. PubMed ID: 21190322
[TBL] [Abstract][Full Text] [Related]
3. Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.
Luo Y; Walla M; Wyatt MD
DNA Repair (Amst); 2008 Feb; 7(2):162-9. PubMed ID: 17942376
[TBL] [Abstract][Full Text] [Related]
4. Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition.
Welsh SJ; Hobbs S; Aherne GW
Eur J Cancer; 2003 Feb; 39(3):378-87. PubMed ID: 12565992
[TBL] [Abstract][Full Text] [Related]
5. dUTPase inhibition confers susceptibility to a thymidylate synthase inhibitor in DNA-repair-defective human cancer cells.
Yokogawa T; Yano W; Tsukioka S; Osada A; Wakasa T; Ueno H; Hoshino T; Yamamura K; Fujioka A; Fukuoka M; Ohkubo S; Matsuo K
Cancer Sci; 2021 Jan; 112(1):422-432. PubMed ID: 33140501
[TBL] [Abstract][Full Text] [Related]
6. Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts.
Andersen S; Heine T; Sneve R; König I; Krokan HE; Epe B; Nilsen H
Carcinogenesis; 2005 Mar; 26(3):547-55. PubMed ID: 15564287
[TBL] [Abstract][Full Text] [Related]
7. Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration.
Weil AF; Ghosh D; Zhou Y; Seiple L; McMahon MA; Spivak AM; Siliciano RF; Stivers JT
Proc Natl Acad Sci U S A; 2013 Feb; 110(6):E448-57. PubMed ID: 23341616
[TBL] [Abstract][Full Text] [Related]
8. The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition.
Webley SD; Welsh SJ; Jackman AL; Aherne GW
Br J Cancer; 2001 Aug; 85(3):446-52. PubMed ID: 11487279
[TBL] [Abstract][Full Text] [Related]
9. Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication.
Nilsen H; Rosewell I; Robins P; Skjelbred CF; Andersen S; Slupphaug G; Daly G; Krokan HE; Lindahl T; Barnes DE
Mol Cell; 2000 Jun; 5(6):1059-65. PubMed ID: 10912000
[TBL] [Abstract][Full Text] [Related]
10. UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Pettersen HS; Visnes T; Vågbø CB; Svaasand EK; Doseth B; Slupphaug G; Kavli B; Krokan HE
Nucleic Acids Res; 2011 Oct; 39(19):8430-44. PubMed ID: 21745813
[TBL] [Abstract][Full Text] [Related]
11. Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.
Masaoka A; Matsubara M; Hasegawa R; Tanaka T; Kurisu S; Terato H; Ohyama Y; Karino N; Matsuda A; Ide H
Biochemistry; 2003 May; 42(17):5003-12. PubMed ID: 12718543
[TBL] [Abstract][Full Text] [Related]
12. SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress.
Nagaria P; Svilar D; Brown AR; Wang XH; Sobol RW; Wyatt MD
Mutat Res; 2013; 743-744():26-32. PubMed ID: 23253900
[TBL] [Abstract][Full Text] [Related]
13. Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase.
Fischer JA; Muller-Weeks S; Caradonna SJ
Cancer Res; 2006 Sep; 66(17):8829-37. PubMed ID: 16951200
[TBL] [Abstract][Full Text] [Related]
14. hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup.
Kavli B; Sundheim O; Akbari M; Otterlei M; Nilsen H; Skorpen F; Aas PA; Hagen L; Krokan HE; Slupphaug G
J Biol Chem; 2002 Oct; 277(42):39926-36. PubMed ID: 12161446
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil.
Christenson ES; Gizzi A; Cui J; Egleston M; Seamon KJ; DePasquale M; Orris B; Park BH; Stivers JT
Mol Pharmacol; 2021 Jun; 99(6):412-425. PubMed ID: 33795350
[TBL] [Abstract][Full Text] [Related]
16. Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition.
Koehler SE; Ladner RD
Mol Pharmacol; 2004 Sep; 66(3):620-6. PubMed ID: 15322254
[TBL] [Abstract][Full Text] [Related]
17. The role of dUTPase and uracil-DNA repair in cancer chemotherapy.
Ladner RD
Curr Protein Pept Sci; 2001 Dec; 2(4):361-70. PubMed ID: 12374095
[TBL] [Abstract][Full Text] [Related]
18. 5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity.
An Q; Robins P; Lindahl T; Barnes DE
Cancer Res; 2007 Feb; 67(3):940-5. PubMed ID: 17283124
[TBL] [Abstract][Full Text] [Related]
19. Excision of uracil from transcribed DNA negatively affects gene expression.
Lühnsdorf B; Epe B; Khobta A
J Biol Chem; 2014 Aug; 289(32):22008-18. PubMed ID: 24951587
[TBL] [Abstract][Full Text] [Related]
20. Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination.
Huehls AM; Huntoon CJ; Joshi PM; Baehr CA; Wagner JM; Wang X; Lee MY; Karnitz LM
Mol Pharmacol; 2016 Jan; 89(1):53-62. PubMed ID: 26494862
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
