These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
94 related articles for article (PubMed ID: 21235240)
1. 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies. Zhang Z; Wu G; Xie F; Song T; Chang X J Med Chem; 2011 Feb; 54(4):1101-5. PubMed ID: 21235240 [TBL] [Abstract][Full Text] [Related]
2. 3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. Song T; Li X; Chang X; Liang X; Zhao Y; Wu G; Xie S; Su P; Wu Z; Feng Y; Zhang Z Bioorg Med Chem; 2013 Jan; 21(1):11-20. PubMed ID: 23206987 [TBL] [Abstract][Full Text] [Related]
3. Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design. Zhang Z; Yang H; Wu G; Li Z; Song T; Li XQ Eur J Med Chem; 2011 Sep; 46(9):3909-16. PubMed ID: 21684048 [TBL] [Abstract][Full Text] [Related]
4. Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents. Zhang Z; Jin L; Qian X; Wei M; Wang Y; Wang J; Yang Y; Xu Q; Xu Y; Liu F Chembiochem; 2007 Jan; 8(1):113-21. PubMed ID: 17139689 [TBL] [Abstract][Full Text] [Related]
5. Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors. Zhang Z; Liu C; Li X; Song T; Wu Z; Liang X; Zhao Y; Shen X; Chen H Eur J Med Chem; 2013 Feb; 60():410-20. PubMed ID: 23314054 [TBL] [Abstract][Full Text] [Related]
6. Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach. Zhang Z; Song T; Li X; Wu Z; Feng Y; Xie F; Liu C; Qin J; Chen H Eur J Med Chem; 2013 Jan; 59():141-9. PubMed ID: 23220642 [TBL] [Abstract][Full Text] [Related]
7. A novel small molecule inhibitor targeted at Bcl-2. Jin L; Zhang Z; Wang Y; Wei M; Xu Q Sci China C Life Sci; 2007 Oct; 50(5):624-9. PubMed ID: 17879060 [TBL] [Abstract][Full Text] [Related]
8. Design, synthesis, and antitumor evaluation of novel acenaphtho[1,2-b]pyrrole-carboxylic acid esters with amino chain substitution. Liu F; Qian X; Cui J; Xiao Y; Zhang R; Li G Bioorg Med Chem; 2006 Jul; 14(13):4639-44. PubMed ID: 16516477 [TBL] [Abstract][Full Text] [Related]
9. Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: synthesis, cytotoxicity, DNA-binding and cell cycle evaluation. Xie L; Xiao Y; Wang F; Xu Y; Qian X; Zhang R; Cui J; Liu J Bioorg Med Chem; 2009 Nov; 17(21):7615-21. PubMed ID: 19815418 [TBL] [Abstract][Full Text] [Related]
10. Preclinical studies of TW-37, a new nonpeptidic small-molecule inhibitor of Bcl-2, in diffuse large cell lymphoma xenograft model reveal drug action on both Bcl-2 and Mcl-1. Mohammad RM; Goustin AS; Aboukameel A; Chen B; Banerjee S; Wang G; Nikolovska-Coleska Z; Wang S; Al-Katib A Clin Cancer Res; 2007 Apr; 13(7):2226-35. PubMed ID: 17404107 [TBL] [Abstract][Full Text] [Related]
11. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold. Niu Q; Deng H; Zhang Z; Xu Q; Luan S; Huang M; Liu D; Zhao L Bioorg Med Chem Lett; 2021 Sep; 47():128215. PubMed ID: 34153472 [TBL] [Abstract][Full Text] [Related]
12. Novel Mcl-1/Bcl-2 dual inhibitors created by the structure-based hybridization of drug-divided building blocks and a fragment deconstructed from a known two-face BH3 mimetic. Zhang Z; Su P; Li X; Song T; Chai G; Yu X; Zhang K Arch Pharm (Weinheim); 2015 Feb; 348(2):89-99. PubMed ID: 25641608 [TBL] [Abstract][Full Text] [Related]
13. Acenaphtho[1,2-b]pyrrole-based selective fibroblast growth factor receptors 1 (FGFR1) inhibitors: design, synthesis, and biological activity. Chen Z; Wang X; Zhu W; Cao X; Tong L; Li H; Xie H; Xu Y; Tan S; Kuang D; Ding J; Qian X J Med Chem; 2011 Jun; 54(11):3732-45. PubMed ID: 21517068 [TBL] [Abstract][Full Text] [Related]
14. 1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation. Xu G; Liu T; Zhou Y; Yang X; Fang H Bioorg Med Chem; 2017 Oct; 25(20):5548-5556. PubMed ID: 28866374 [TBL] [Abstract][Full Text] [Related]
15. Pan-BH3 mimetic S1 exhibits broad-spectrum antitumour effects by cooperation between Bax and Bak. Song T; Xue Z; Zhang Z; Shen X; Li X Basic Clin Pharmacol Toxicol; 2013 Sep; 113(3):145-51. PubMed ID: 23557083 [TBL] [Abstract][Full Text] [Related]
16. Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: various DNA binding geometry and interesting antitumor capacity. Zhang Z; Yang Y; Zhang D; Wang Y; Qian X; Liu F Bioorg Med Chem; 2006 Oct; 14(20):6962-70. PubMed ID: 16828559 [TBL] [Abstract][Full Text] [Related]
17. Discovery of selective Mcl-1 inhibitors via structure-based design and structure-activity relationship analysis. He N; Liu P; Wang Z; Guo Z; Yan X; Chen H; Zhang Z Biochem Biophys Res Commun; 2019 May; 512(4):921-926. PubMed ID: 30928099 [TBL] [Abstract][Full Text] [Related]
18. Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins. Tang G; Yang CY; Nikolovska-Coleska Z; Guo J; Qiu S; Wang R; Gao W; Wang G; Stuckey J; Krajewski K; Jiang S; Roller PP; Wang S J Med Chem; 2007 Apr; 50(8):1723-6. PubMed ID: 17378545 [TBL] [Abstract][Full Text] [Related]
19. Fragment-Based Design, Synthesis, and Biological Evaluation of 1-Substituted-indole-2-carboxylic Acids as Selective Mcl-1 Inhibitors. Wang Z; Xu W; Song T; Guo Z; Liu L; Fan Y; Wang A; Zhang Z Arch Pharm (Weinheim); 2017 Jan; 350(1):. PubMed ID: 27911011 [TBL] [Abstract][Full Text] [Related]
20. Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. Bruncko M; Oost TK; Belli BA; Ding H; Joseph MK; Kunzer A; Martineau D; McClellan WJ; Mitten M; Ng SC; Nimmer PM; Oltersdorf T; Park CM; Petros AM; Shoemaker AR; Song X; Wang X; Wendt MD; Zhang H; Fesik SW; Rosenberg SH; Elmore SW J Med Chem; 2007 Feb; 50(4):641-62. PubMed ID: 17256834 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]