These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 21239484)

  • 1. Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2.
    Marion V; Sankaranarayanan S; de Theije C; van Dijk P; Lindsey P; Lamers MC; Harding HP; Ron D; Lamers WH; Köhler SE
    J Biol Chem; 2011 Mar; 286(11):8866-74. PubMed ID: 21239484
    [TBL] [Abstract][Full Text] [Related]  

  • 2. GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.
    Bunpo P; Dudley A; Cundiff JK; Cavener DR; Wek RC; Anthony TG
    J Biol Chem; 2009 Nov; 284(47):32742-9. PubMed ID: 19783659
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Increased milk protein synthesis in response to exogenous growth hormone is associated with changes in mechanistic (mammalian) target of rapamycin (mTOR)C1-dependent and independent cell signaling.
    Sciascia Q; Pacheco D; McCoard SA
    J Dairy Sci; 2013 Apr; 96(4):2327-2338. PubMed ID: 23462168
    [TBL] [Abstract][Full Text] [Related]  

  • 4. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.
    Averous J; Lambert-Langlais S; Mesclon F; Carraro V; Parry L; Jousse C; Bruhat A; Maurin AC; Pierre P; Proud CG; Fafournoux P
    Sci Rep; 2016 Jun; 6():27698. PubMed ID: 27297692
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.
    Nikonorova IA; Mirek ET; Signore CC; Goudie MP; Wek RC; Anthony TG
    J Biol Chem; 2018 Apr; 293(14):5005-5015. PubMed ID: 29449374
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling.
    Brüggenthies JB; Fiore A; Russier M; Bitsina C; Brötzmann J; Kordes S; Menninger S; Wolf A; Conti E; Eickhoff JE; Murray PJ
    J Biol Chem; 2022 Dec; 298(12):102629. PubMed ID: 36273589
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1).
    Dennis MD; McGhee NK; Jefferson LS; Kimball SR
    Cell Signal; 2013 Dec; 25(12):2709-16. PubMed ID: 24018049
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.
    Nikonorova IA; Al-Baghdadi RJT; Mirek ET; Wang Y; Goudie MP; Wetstein BB; Dixon JL; Hine C; Mitchell JR; Adams CM; Wek RC; Anthony TG
    J Biol Chem; 2017 Apr; 292(16):6786-6798. PubMed ID: 28242759
    [TBL] [Abstract][Full Text] [Related]  

  • 9. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
    Ye J; Palm W; Peng M; King B; Lindsten T; Li MO; Koumenis C; Thompson CB
    Genes Dev; 2015 Nov; 29(22):2331-6. PubMed ID: 26543160
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress.
    Misra J; Holmes MJ; T Mirek E; Langevin M; Kim HG; Carlson KR; Watford M; Dong XC; Anthony TG; Wek RC
    Nucleic Acids Res; 2021 Jun; 49(10):5726-5742. PubMed ID: 34023907
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.
    Wilson GJ; Bunpo P; Cundiff JK; Wek RC; Anthony TG
    Am J Physiol Endocrinol Metab; 2013 Nov; 305(9):E1124-33. PubMed ID: 24002574
    [TBL] [Abstract][Full Text] [Related]  

  • 12. GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells.
    Mazor KM; Stipanuk MH
    Amino Acids; 2016 Dec; 48(12):2831-2842. PubMed ID: 27613409
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Overexpression of arginase I in enterocytes of transgenic mice elicits a selective arginine deficiency and affects skin, muscle, and lymphoid development.
    de Jonge WJ; Hallemeesch MM; Kwikkers KL; Ruijter JM; de Gier-de Vries C; van Roon MA; Meijer AJ; Marescau B; de Deyn PP; Deutz NE; Lamers WH
    Am J Clin Nutr; 2002 Jul; 76(1):128-40. PubMed ID: 12081826
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.
    Anthony TG; McDaniel BJ; Byerley RL; McGrath BC; Cavener DR; McNurlan MA; Wek RC
    J Biol Chem; 2004 Aug; 279(35):36553-61. PubMed ID: 15213227
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crosstalk of humoral and cell-cell contact-mediated signals in postnatal body growth.
    Jing X; Miyajima M; Sawada T; Chen Q; Iida K; Furushima K; Arai D; Chihara K; Sakaguchi K
    Cell Rep; 2012 Sep; 2(3):652-65. PubMed ID: 22999939
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
    Wengrod J; Wang D; Weiss S; Zhong H; Osman I; Gardner LB
    Sci Signal; 2015 Mar; 8(367):ra27. PubMed ID: 25759478
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.
    Al-Baghdadi RJT; Nikonorova IA; Mirek ET; Wang Y; Park J; Belden WJ; Wek RC; Anthony TG
    Sci Rep; 2017 Apr; 7(1):1272. PubMed ID: 28455513
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism.
    Guridi M; Kupr B; Romanino K; Lin S; Falcetta D; Tintignac L; Rüegg MA
    Skelet Muscle; 2016; 6():13. PubMed ID: 27004103
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice.
    de Jonge WJ; Kwikkers KL; te Velde AA; van Deventer SJ; Nolte MA; Mebius RE; Ruijter JM; Lamers MC; Lamers WH
    J Clin Invest; 2002 Nov; 110(10):1539-48. PubMed ID: 12438451
    [TBL] [Abstract][Full Text] [Related]  

  • 20. AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.
    Tandelilin AA; Hirase T; Hudoyo AW; Cheng J; Toyama K; Morisaki H; Morisaki T
    BMC Endocr Disord; 2015 Mar; 15():11. PubMed ID: 25887856
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.