BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 21245530)

  • 81. Hybridization arrest of cell-free translation of the malarial dihydrofolate reductase/thymidylate synthase mRNA by anti-sense oligodeoxyribonucleotides.
    Sartorius C; Franklin RM
    Nucleic Acids Res; 1991 Apr; 19(7):1613-8. PubMed ID: 2027768
    [TBL] [Abstract][Full Text] [Related]  

  • 82. Complete restoration of activity to inactive mutants of Escherichia coli thymidylate synthase: evidence that E. coli thymidylate synthase is a half-the-sites activity enzyme.
    Maley F; Pedersen-Lane J; Changchien L
    Biochemistry; 1995 Feb; 34(5):1469-74. PubMed ID: 7849005
    [TBL] [Abstract][Full Text] [Related]  

  • 83. Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase.
    Czyzyk DJ; Valhondo M; Jorgensen WL; Anderson KS
    FEBS Lett; 2019 Aug; 593(15):2069-2078. PubMed ID: 31172516
    [TBL] [Abstract][Full Text] [Related]  

  • 84. X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.
    Catalano A; Luciani R; Carocci A; Cortesi D; Pozzi C; Borsari C; Ferrari S; Mangani S
    Eur J Med Chem; 2016 Nov; 123():649-664. PubMed ID: 27517810
    [TBL] [Abstract][Full Text] [Related]  

  • 85. Thymidylate synthase as a translational regulator of cellular gene expression.
    Liu J; Schmitz JC; Lin X; Tai N; Yan W; Farrell M; Bailly M; Chen Tm; Chu E
    Biochim Biophys Acta; 2002 Jul; 1587(2-3):174-82. PubMed ID: 12084459
    [TBL] [Abstract][Full Text] [Related]  

  • 86. Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.
    Fritz TA; Tondi D; Finer-Moore JS; Costi MP; Stroud RM
    Chem Biol; 2001 Oct; 8(10):981-95. PubMed ID: 11590022
    [TBL] [Abstract][Full Text] [Related]  

  • 87. Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89.
    Weichsel A; Montfort WR
    Nat Struct Biol; 1995 Dec; 2(12):1095-101. PubMed ID: 8846221
    [TBL] [Abstract][Full Text] [Related]  

  • 88. Significance of mutations on the structural perturbation of thymidylate synthase: implications for their involvement in subunit exchange.
    Saxl RL; Maley GF; Hauer CR; Maccoll R; Changchien L; Maley F
    Protein Sci; 2007 Jul; 16(7):1439-48. PubMed ID: 17586776
    [TBL] [Abstract][Full Text] [Related]  

  • 89. Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
    Huang X; Gibson LM; Bell BJ; Lovelace LL; Peña MM; Berger FG; Berger SH; Lebioda L
    Biochemistry; 2010 Mar; 49(11):2475-82. PubMed ID: 20151707
    [TBL] [Abstract][Full Text] [Related]  

  • 90. Structure-based discovery of inhibitors of thymidylate synthase.
    Shoichet BK; Stroud RM; Santi DV; Kuntz ID; Perry KM
    Science; 1993 Mar; 259(5100):1445-50. PubMed ID: 8451640
    [TBL] [Abstract][Full Text] [Related]  

  • 91. Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein.
    Mathews II; Deacon AM; Canaves JM; McMullan D; Lesley SA; Agarwalla S; Kuhn P
    Structure; 2003 Jun; 11(6):677-90. PubMed ID: 12791256
    [TBL] [Abstract][Full Text] [Related]  

  • 92. Regulation of mouse thymidylate synthase gene expression in growth-stimulated cells: upstream S phase control elements are indistinguishable from the essential promoter elements.
    Ash J; Liao WC; Ke Y; Johnson LF
    Nucleic Acids Res; 1995 Nov; 23(22):4649-56. PubMed ID: 8524656
    [TBL] [Abstract][Full Text] [Related]  

  • 93. Mechanism of hairpin-duplex conversion for the HIV-1 dimerization initiation site.
    Bernacchi S; Ennifar E; Tóth K; Walter P; Langowski J; Dumas P
    J Biol Chem; 2005 Dec; 280(48):40112-21. PubMed ID: 16169845
    [TBL] [Abstract][Full Text] [Related]  

  • 94. A mouse thymidylate synthase pseudogene derived from an aberrantly processed RNA molecule.
    Li DW; Johnson LF
    Gene; 1989 Oct; 82(2):363-70. PubMed ID: 2573561
    [TBL] [Abstract][Full Text] [Related]  

  • 95. Transcriptional control elements of the rat thymidylate synthase promoter: evolutionary conservation of regulatory features.
    Lee Y; Johnson LF
    Exp Cell Res; 2000 Jul; 258(1):53-64. PubMed ID: 10912787
    [TBL] [Abstract][Full Text] [Related]  

  • 96. Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution.
    Sampathkumar P; Turley S; Ulmer JE; Rhie HG; Sibley CH; Hol WG
    J Mol Biol; 2005 Oct; 352(5):1091-104. PubMed ID: 16139296
    [TBL] [Abstract][Full Text] [Related]  

  • 97. Amino acid substitution analysis of E. coli thymidylate synthase: the study of a highly conserved region at the N-terminus.
    Kim CW; Michaels ML; Miller JH
    Proteins; 1992 Aug; 13(4):352-63. PubMed ID: 1518803
    [TBL] [Abstract][Full Text] [Related]  

  • 98. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
    Fantz C; Shaw D; Jennings W; Forsthoefel A; Kitchens M; Phan J; Minor W; Lebioda L; Berger FG; Spencer HT
    Mol Pharmacol; 2000 Feb; 57(2):359-66. PubMed ID: 10648646
    [TBL] [Abstract][Full Text] [Related]  

  • 99. Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation.
    Landau MJ; Sharma H; Anderson KS
    Protein Sci; 2013 Sep; 22(9):1161-73. PubMed ID: 23813474
    [TBL] [Abstract][Full Text] [Related]  

  • 100. D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
    Sage CR; Michelitsch MD; Stout TJ; Biermann D; Nissen R; Finer-Moore J; Stroud RM
    Biochemistry; 1998 Sep; 37(39):13893-901. PubMed ID: 9753479
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.