212 related articles for article (PubMed ID: 21248371)
1. HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.
Nardinocchi L; Puca R; D'Orazi G
Aging (Albany NY); 2011 Jan; 3(1):33-43. PubMed ID: 21248371
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis.
Nardinocchi L; Puca R; Sacchi A; D'Orazi G
Mol Cancer; 2009 Jan; 8():1. PubMed ID: 19128456
[TBL] [Abstract][Full Text] [Related]
3. Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.
Nardinocchi L; Puca R; Sacchi A; Rechavi G; Givol D; D'Orazi G
PLoS One; 2009 Aug; 4(8):e6819. PubMed ID: 19714248
[TBL] [Abstract][Full Text] [Related]
4. HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1α inhibition.
Nardinocchi L; Puca R; Givol D; D'Orazi G
Cell Cycle; 2010 Apr; 9(7):1270-5. PubMed ID: 20234185
[TBL] [Abstract][Full Text] [Related]
5. Hyperglycemia triggers HIPK2 protein degradation.
Baldari S; Garufi A; Granato M; Cuomo L; Pistritto G; Cirone M; D'Orazi G
Oncotarget; 2017 Jan; 8(1):1190-1203. PubMed ID: 27901482
[TBL] [Abstract][Full Text] [Related]
6. HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α.
Chen P; Duan X; Li X; Li J; Ba Q; Wang H
Oncogene; 2020 Apr; 39(14):2863-2876. PubMed ID: 32034309
[TBL] [Abstract][Full Text] [Related]
7. Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells.
Nardinocchi L; Puca R; Givol D; D'Orazi G
FEBS Lett; 2010 Oct; 584(19):4253-8. PubMed ID: 20849851
[TBL] [Abstract][Full Text] [Related]
8. Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth.
Nardinocchi L; Puca R; Guidolin D; Belloni AS; Bossi G; Michiels C; Sacchi A; Onisto M; D'Orazi G
Biochim Biophys Acta; 2009 Feb; 1793(2):368-77. PubMed ID: 19046997
[TBL] [Abstract][Full Text] [Related]
9. Targeting COX-2/PGE(2) pathway in HIPK2 knockdown cancer cells: impact on dendritic cell maturation.
Garufi A; Pistritto G; Ceci C; Di Renzo L; Santarelli R; Faggioni A; Cirone M; D'Orazi G
PLoS One; 2012; 7(11):e48342. PubMed ID: 23144866
[TBL] [Abstract][Full Text] [Related]
10. Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB.
Rohwer N; Dame C; Haugstetter A; Wiedenmann B; Detjen K; Schmitt CA; Cramer T
PLoS One; 2010 Aug; 5(8):e12038. PubMed ID: 20706634
[TBL] [Abstract][Full Text] [Related]
11. Hypoxia-inducible factor-1α protects cervical carcinoma cells from apoptosis induced by radiation via modulation of vascular endothelial growth factor and p53 under hypoxia.
Fu Z; Chen D; Cheng H; Wang F
Med Sci Monit; 2015 Jan; 21():318-25. PubMed ID: 25623525
[TBL] [Abstract][Full Text] [Related]
12. Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1alpha-induced gene in pancreatic cancer.
Baker AF; Koh MY; Williams RR; James B; Wang H; Tate WR; Gallegos A; Von Hoff DD; Han H; Powis G
Pancreas; 2008 Mar; 36(2):178-86. PubMed ID: 18376310
[TBL] [Abstract][Full Text] [Related]
13. Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity.
D'Orazi G; Garufi A; Cirone M
IUBMB Life; 2020 Aug; 72(8):1634-1639. PubMed ID: 32593231
[TBL] [Abstract][Full Text] [Related]
14. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.
Rui Y; Xu Z; Lin S; Li Q; Rui H; Luo W; Zhou HM; Cheung PY; Wu Z; Ye Z; Li P; Han J; Lin SC
EMBO J; 2004 Nov; 23(23):4583-94. PubMed ID: 15526030
[TBL] [Abstract][Full Text] [Related]
15. Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy.
Zhang X; Qi Z; Yin H; Yang G
Theranostics; 2019; 9(4):1096-1114. PubMed ID: 30867818
[TBL] [Abstract][Full Text] [Related]
16. Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis.
Di Stefano V; Rinaldo C; Sacchi A; Soddu S; D'Orazi G
Exp Cell Res; 2004 Feb; 293(2):311-20. PubMed ID: 14729469
[TBL] [Abstract][Full Text] [Related]
17. Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression.
Peng XH; Karna P; Cao Z; Jiang BH; Zhou M; Yang L
J Biol Chem; 2006 Sep; 281(36):25903-14. PubMed ID: 16847054
[TBL] [Abstract][Full Text] [Related]
18. Severity and duration of hypoxic stress differentially regulates HIF-1α-mediated cardiomyocyte apoptotic signaling milieu during myocardial infarction.
Datta Chaudhuri R; Banerjee D; Banik A; Sarkar S
Arch Biochem Biophys; 2020 Sep; 690():108430. PubMed ID: 32473132
[TBL] [Abstract][Full Text] [Related]
19. UVC inhibits HIF-1alpha protein translation by a DNA damage- and topoisomerase I-independent pathway.
Rapisarda A; Melillo G
Oncogene; 2007 Oct; 26(48):6875-84. PubMed ID: 17496931
[TBL] [Abstract][Full Text] [Related]
20. Modeling the interplay between the HIF-1 and p53 pathways in hypoxia.
Zhou CH; Zhang XP; Liu F; Wang W
Sci Rep; 2015 Sep; 5():13834. PubMed ID: 26346319
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
