BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

213 related articles for article (PubMed ID: 21252227)

  • 21. α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement.
    Chu X; Tae HS; Xu Q; Jiang T; Adams DJ; Yu R
    ACS Chem Neurosci; 2019 Oct; 10(10):4328-4336. PubMed ID: 31411453
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.
    Callaghan B; Haythornthwaite A; Berecki G; Clark RJ; Craik DJ; Adams DJ
    J Neurosci; 2008 Oct; 28(43):10943-51. PubMed ID: 18945902
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Are alpha9alpha10 nicotinic acetylcholine receptors a pain target for alpha-conotoxins?
    Nevin ST; Clark RJ; Klimis H; Christie MJ; Craik DJ; Adams DJ
    Mol Pharmacol; 2007 Dec; 72(6):1406-10. PubMed ID: 17804600
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Analgesic α-conotoxins modulate native and recombinant GIRK1/2 channels via activation of GABA
    Bony AR; McArthur JR; Finol-Urdaneta RK; Adams DJ
    Br J Pharmacol; 2022 Jan; 179(1):179-198. PubMed ID: 34599513
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif.
    Carstens BB; Berecki G; Daniel JT; Lee HS; Jackson KA; Tae HS; Sadeghi M; Castro J; O'Donnell T; Deiteren A; Brierley SM; Craik DJ; Adams DJ; Clark RJ
    Angew Chem Int Ed Engl; 2016 Apr; 55(15):4692-6. PubMed ID: 26948522
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors.
    Huynh PN; Harvey PJ; Gajewiak J; Craik DJ; Michael McIntosh J
    Biochem Pharmacol; 2020 Nov; 181():114124. PubMed ID: 32593612
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor.
    Halai R; Callaghan B; Daly NL; Clark RJ; Adams DJ; Craik DJ
    J Med Chem; 2011 Oct; 54(19):6984-92. PubMed ID: 21888386
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABA(B) receptor.
    Huynh TG; Cuny H; Slesinger PA; Adams DJ
    Mol Pharmacol; 2015 Feb; 87(2):240-50. PubMed ID: 25425625
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms.
    Tsetlin V; Haufe Y; Safronova V; Serov D; Shadamarshan P; Son L; Shelukhina I; Kudryavtsev D; Kryukova E; Kasheverov I; Nicke A; Utkin Y
    Front Cell Neurosci; 2021; 15():765541. PubMed ID: 35002625
    [TBL] [Abstract][Full Text] [Related]  

  • 30. d-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability.
    Ren J; Zhu X; Xu P; Li R; Fu Y; Dong S; Zhangsun D; Wu Y; Luo S
    Mar Drugs; 2019 Feb; 17(3):. PubMed ID: 30823399
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor.
    Luo S; Akondi KB; Zhangsun D; Wu Y; Zhu X; Hu Y; Christensen S; Dowell C; Daly NL; Craik DJ; Wang CI; Lewis RJ; Alewood PF; Michael McIntosh J
    J Biol Chem; 2010 Apr; 285(16):12355-66. PubMed ID: 20145249
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Dimerization of α-Conotoxins as a Strategy to Enhance the Inhibition of the Human α7 and α9α10 Nicotinic Acetylcholine Receptors.
    Liang J; Tae HS; Xu X; Jiang T; Adams DJ; Yu R
    J Med Chem; 2020 Mar; 63(6):2974-2985. PubMed ID: 32101438
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Alpha-conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californica and some neuronal subtypes of nicotinic acetylcholine receptors.
    Kasheverov IE; Zhmak MN; Vulfius CA; Gorbacheva EV; Mordvintsev DY; Utkin YN; van Elk R; Smit AB; Tsetlin VI
    FEBS J; 2006 Oct; 273(19):4470-81. PubMed ID: 16956365
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding.
    Zhangsun D; Zhu X; Wu Y; Hu Y; Kaas Q; Craik DJ; McIntosh JM; Luo S
    J Biol Chem; 2015 Apr; 290(15):9855-62. PubMed ID: 25713061
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Identification of Crucial Residues in α-Conotoxin EI Inhibiting Muscle Nicotinic Acetylcholine Receptor.
    Ning J; Ren J; Xiong Y; Wu Y; Zhangsun M; Zhangsun D; Zhu X; Luo S
    Toxins (Basel); 2019 Oct; 11(10):. PubMed ID: 31623211
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins.
    Cuny H; Kompella SN; Tae HS; Yu R; Adams DJ
    J Biol Chem; 2016 Nov; 291(45):23779-23792. PubMed ID: 27646000
    [TBL] [Abstract][Full Text] [Related]  

  • 37. PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors.
    Hone AJ; Fisher F; Christensen S; Gajewiak J; Larkin D; Whiteaker P; McIntosh JM
    J Med Chem; 2019 Jul; 62(13):6262-6275. PubMed ID: 31194549
    [TBL] [Abstract][Full Text] [Related]  

  • 38. αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.
    Zhangsun D; Zhu X; Kaas Q; Wu Y; Craik DJ; McIntosh JM; Luo S
    Neuropharmacology; 2017 Dec; 127():243-252. PubMed ID: 28416445
    [TBL] [Abstract][Full Text] [Related]  

  • 39. α-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks α6β2β3 versus α6β4 nicotinic acetylcholine receptors.
    Hone AJ; Scadden M; Gajewiak J; Christensen S; Lindstrom J; McIntosh JM
    Mol Pharmacol; 2012 Nov; 82(5):972-82. PubMed ID: 22914547
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Characterisation of Elevenin-Vc1 from the Venom of
    Krishnarjuna B; Sunanda P; Seow J; Tae HS; Robinson SD; Belgi A; Robinson AJ; Safavi-Hemami H; Adams DJ; Norton RS
    Mar Drugs; 2023 Jan; 21(2):. PubMed ID: 36827123
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.