151 related articles for article (PubMed ID: 21252290)
1. A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.
Zhou X; Wei Y; Xie F; Laukaitis CM; Karn RC; Kluetzman K; Gu J; Zhang QY; Roberts DW; Ding X
Mol Pharmacol; 2011 Apr; 79(4):710-23. PubMed ID: 21252290
[TBL] [Abstract][Full Text] [Related]
2. Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression.
Zhuo X; Gu J; Behr MJ; Swiatek PJ; Cui H; Zhang QY; Xie Y; Collins DN; Ding X
J Pharmacol Exp Ther; 2004 Feb; 308(2):719-28. PubMed ID: 14610229
[TBL] [Abstract][Full Text] [Related]
3. Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.
Zhou X; Zhuo X; Xie F; Kluetzman K; Shu YZ; Humphreys WG; Ding X
J Pharmacol Exp Ther; 2010 Feb; 332(2):578-87. PubMed ID: 19923441
[TBL] [Abstract][Full Text] [Related]
4. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse.
Genter MB; Liang HC; Gu J; Ding X; Negishi M; McKinnon RA; Nebert DW
Biochem Pharmacol; 1998 Jun; 55(11):1819-26. PubMed ID: 9714300
[TBL] [Abstract][Full Text] [Related]
5. Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.
Zhou X; D'Agostino J; Li L; Moore CD; Yost GS; Ding X
Drug Metab Dispos; 2012 Apr; 40(4):642-7. PubMed ID: 22228748
[TBL] [Abstract][Full Text] [Related]
6. Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.
Hu J; Sheng L; Li L; Zhou X; Xie F; D'Agostino J; Li Y; Ding X
Drug Metab Dispos; 2014 Jan; 42(1):23-7. PubMed ID: 24104196
[TBL] [Abstract][Full Text] [Related]
7. Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes.
Gu J; Zhang QY; Genter MB; Lipinskas TW; Negishi M; Nebert DW; Ding X
J Pharmacol Exp Ther; 1998 Jun; 285(3):1287-95. PubMed ID: 9618435
[TBL] [Abstract][Full Text] [Related]
8. The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5.
Xie F; Zhou X; Genter MB; Behr M; Gu J; Ding X
Drug Metab Dispos; 2011 Jun; 39(6):947-51. PubMed ID: 21415250
[TBL] [Abstract][Full Text] [Related]
9. Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.
Xie F; Zhou X; Behr M; Fang C; Horii Y; Gu J; Kannan K; Ding X
Toxicol Appl Pharmacol; 2010 Nov; 249(1):101-6. PubMed ID: 20840855
[TBL] [Abstract][Full Text] [Related]
10. High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice.
Zhou X; Zhang X; Weng Y; Fang C; Kaminsky L; Ding X
J Steroid Biochem Mol Biol; 2009 Oct; 117(1-3):81-6. PubMed ID: 19524040
[TBL] [Abstract][Full Text] [Related]
11. Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: different requirement for transcription factor nuclear factor erythroid- derived 2-like 2.
Lämsä V; Levonen AL; Sormunen R; Yamamoto M; Hakkola J
Toxicol Sci; 2012 Nov; 130(1):132-44. PubMed ID: 22859313
[TBL] [Abstract][Full Text] [Related]
12. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
Zaher H; Buters JT; Ward JM; Bruno MK; Lucas AM; Stern ST; Cohen SD; Gonzalez FJ
Toxicol Appl Pharmacol; 1998 Sep; 152(1):193-9. PubMed ID: 9772215
[TBL] [Abstract][Full Text] [Related]
13. In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa.
Gu J; Cui H; Behr M; Zhang L; Zhang QY; Yang W; Hinson JA; Ding X
Mol Pharmacol; 2005 Mar; 67(3):623-30. PubMed ID: 15550675
[TBL] [Abstract][Full Text] [Related]
14. Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.
Lavery DJ; Lopez-Molina L; Margueron R; Fleury-Olela F; Conquet F; Schibler U; Bonfils C
Mol Cell Biol; 1999 Oct; 19(10):6488-99. PubMed ID: 10490589
[TBL] [Abstract][Full Text] [Related]
15. Cell-specific expression of CYP2A5 in the mouse respiratory tract: effects of olfactory toxicants.
Piras E; Franzén A; Fernández EL; Bergström U; Raffalli-Mathieu F; Lang M; Brittebo EB
J Histochem Cytochem; 2003 Nov; 51(11):1545-55. PubMed ID: 14566026
[TBL] [Abstract][Full Text] [Related]
16. Gender-related differences in susceptibility to acetaminophen-induced protein arylation and nephrotoxicity in the CD-1 mouse.
Hoivik DJ; Manautou JE; Tveit A; Hart SG; Khairallah EA; Cohen SD
Toxicol Appl Pharmacol; 1995 Feb; 130(2):257-71. PubMed ID: 7871539
[TBL] [Abstract][Full Text] [Related]
17. Microarray analysis of hepatic gene expression in pyrazole-mediated hepatotoxicity: identification of potential stimuli of Cyp2a5 induction.
Nichols KD; Kirby GM
Biochem Pharmacol; 2008 Jan; 75(2):538-51. PubMed ID: 17945193
[TBL] [Abstract][Full Text] [Related]
18. Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.
Arpiainen S; Lämsä V; Pelkonen O; Yim SH; Gonzalez FJ; Hakkola J
J Mol Biol; 2007 Jun; 369(3):640-52. PubMed ID: 17466327
[TBL] [Abstract][Full Text] [Related]
19. Regulation of the Cyp2a5 gene involves an aryl hydrocarbon receptor-dependent pathway.
Arpiainen S; Raffalli-Mathieu F; Lang MA; Pelkonen O; Hakkola J
Mol Pharmacol; 2005 Apr; 67(4):1325-33. PubMed ID: 15657367
[TBL] [Abstract][Full Text] [Related]
20. Evidence suggesting the 58-kDa acetaminophen binding protein is a preferential target for acetaminophen electrophile.
Hoivik DJ; Manautou JE; Tveit A; Mankowski DC; Khairallah EA; Cohen SD
Fundam Appl Toxicol; 1996 Jul; 32(1):79-86. PubMed ID: 8812234
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
