These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

157 related articles for article (PubMed ID: 2125487)

  • 1. X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
    Hynes TR; Randal M; Kennedy LA; Eigenbrot C; Kossiakoff AA
    Biochemistry; 1990 Oct; 29(43):10018-22. PubMed ID: 2125487
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
    Scheidig AJ; Hynes TR; Pelletier LA; Wells JA; Kossiakoff AA
    Protein Sci; 1997 Sep; 6(9):1806-24. PubMed ID: 9300481
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure prediction of protease inhibitor region in amyloid precursor protein of Alzheimer's disease.
    Toma K; Kitaguchi N; Ito H
    J Mol Graph; 1989 Dec; 7(4):202-5, 217-8. PubMed ID: 2484810
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Sequential NMR resonance assignment and structure determination of the Kunitz-type inhibitor domain of the Alzheimer's beta-amyloid precursor protein.
    Heald SL; Tilton RF; Hammond LJ; Lee A; Bayney RM; Kamarck ME; Ramabhadran TV; Dreyer RN; Davis G; Unterbeck A
    Biochemistry; 1991 Oct; 30(43):10467-78. PubMed ID: 1718421
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin.
    Salameh MA; Soares AS; Navaneetham D; Sinha D; Walsh PN; Radisky ES
    J Biol Chem; 2010 Nov; 285(47):36884-96. PubMed ID: 20861008
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and characterization of the Kunitz protease-inhibitor domain of the beta-amyloid precursor protein.
    Schilling J; Wang Y; Lau K; Smith L; Cordell B
    Gene; 1991 Feb; 98(2):225-30. PubMed ID: 1707846
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Enzyme specificity of proteinase inhibitor region in amyloid precursor protein of Alzheimer's disease: different properties compared with protease nexin I.
    Kitaguchi N; Takahashi Y; Oishi K; Shiojiri S; Tokushima Y; Utsunomiya T; Ito H
    Biochim Biophys Acta; 1990 Mar; 1038(1):105-13. PubMed ID: 2180485
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Glycosylation of the amyloid peptide precursor containing the Kunitz protease inhibitor domain improves the inhibition of trypsin.
    Godfroid E; Octave JN
    Biochem Biophys Res Commun; 1990 Sep; 171(3):1015-21. PubMed ID: 2121136
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
    Cohen I; Coban M; Shahar A; Sankaran B; Hockla A; Lacham S; Caulfield TR; Radisky ES; Papo N
    J Biol Chem; 2019 Mar; 294(13):5105-5120. PubMed ID: 30700553
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.
    Pendlebury D; Wang R; Henin RD; Hockla A; Soares AS; Madden BJ; Kazanov MD; Radisky ES
    J Biol Chem; 2014 Nov; 289(47):32783-97. PubMed ID: 25301953
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Determination of amyloid beta protein precursors harboring active form of proteinase inhibitor domains in cerebrospinal fluid of Alzheimer's disease patients by trypsin-antibody sandwich ELISA.
    Kitaguchi N; Tokushima Y; Oishi K; Takahashi Y; Shiojiri S; Nakamura S; Tanaka S; Kodaira R; Ito H
    Biochem Biophys Res Commun; 1990 Feb; 166(3):1453-9. PubMed ID: 2106318
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
    Sananes A; Cohen I; Shahar A; Hockla A; De Vita E; Miller AK; Radisky ES; Papo N
    J Biol Chem; 2018 Aug; 293(33):12663-12680. PubMed ID: 29934309
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.
    Tanzi RE; McClatchey AI; Lamperti ED; Villa-Komaroff L; Gusella JF; Neve RL
    Nature; 1988 Feb; 331(6156):528-30. PubMed ID: 2893290
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.
    Salameh MA; Robinson JL; Navaneetham D; Sinha D; Madden BJ; Walsh PN; Radisky ES
    J Biol Chem; 2010 Jan; 285(3):1939-49. PubMed ID: 19920152
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.
    Oltersdorf T; Fritz LC; Schenk DB; Lieberburg I; Johnson-Wood KL; Beattie EC; Ward PJ; Blacher RW; Dovey HF; Sinha S
    Nature; 1989 Sep; 341(6238):144-7. PubMed ID: 2506449
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Does the Kunitz domain from the Alzheimer's amyloid beta protein precursor inhibit a kallikrein responsible for post-translational processing of nerve growth factor precursor?
    Castro M; Marks CB; Nilsson B; Anderson S
    FEBS Lett; 1990 Jul; 267(2):207-12. PubMed ID: 1696210
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases.
    Cohen I; Naftaly S; Ben-Zeev E; Hockla A; Radisky ES; Papo N
    Biochem J; 2018 Apr; 475(7):1335-1352. PubMed ID: 29535275
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
    Ponte P; Gonzalez-DeWhitt P; Schilling J; Miller J; Hsu D; Greenberg B; Davis K; Wallace W; Lieberburg I; Fuller F
    Nature; 1988 Feb; 331(6156):525-7. PubMed ID: 2893289
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Affinity and specificity of serine endopeptidase-protein inhibitor interactions. Empirical free energy calculations based on X-ray crystallographic structures.
    Krystek S; Stouch T; Novotny J
    J Mol Biol; 1993 Dec; 234(3):661-79. PubMed ID: 8254666
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.
    Podlisny MB; Tolan DR; Selkoe DJ
    Am J Pathol; 1991 Jun; 138(6):1423-35. PubMed ID: 1905108
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.