BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 21270171)

  • 1. LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity.
    Meehan AM; Saenz DT; Morrison J; Hu C; Peretz M; Poeschla EM
    J Virol; 2011 Apr; 85(7):3570-83. PubMed ID: 21270171
    [TBL] [Abstract][Full Text] [Related]  

  • 2. LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors.
    Meehan AM; Saenz DT; Morrison JH; Garcia-Rivera JA; Peretz M; Llano M; Poeschla EM
    PLoS Pathog; 2009 Jul; 5(7):e1000522. PubMed ID: 19609362
    [TBL] [Abstract][Full Text] [Related]  

  • 3. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.
    Fadel HJ; Morrison JH; Saenz DT; Fuchs JR; Kvaratskhelia M; Ekker SC; Poeschla EM
    J Virol; 2014 Sep; 88(17):9704-17. PubMed ID: 24942577
    [TBL] [Abstract][Full Text] [Related]  

  • 4. LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs.
    Schrijvers R; De Rijck J; Demeulemeester J; Adachi N; Vets S; Ronen K; Christ F; Bushman FD; Debyser Z; Gijsbers R
    PLoS Pathog; 2012; 8(3):e1002558. PubMed ID: 22396646
    [TBL] [Abstract][Full Text] [Related]  

  • 5. An essential role for LEDGF/p75 in HIV integration.
    Llano M; Saenz DT; Meehan A; Wongthida P; Peretz M; Walker WH; Teo W; Poeschla EM
    Science; 2006 Oct; 314(5798):461-4. PubMed ID: 16959972
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration.
    Badia R; Pauls E; Riveira-Munoz E; Clotet B; Esté JA; Ballana E
    Antimicrob Agents Chemother; 2014 Aug; 58(8):4318-27. PubMed ID: 24820090
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex.
    Maillot B; Lévy N; Eiler S; Crucifix C; Granger F; Richert L; Didier P; Godet J; Pradeau-Aubreton K; Emiliani S; Nazabal A; Lesbats P; Parissi V; Mely Y; Moras D; Schultz P; Ruff M
    PLoS One; 2013; 8(4):e60734. PubMed ID: 23593299
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.
    Hombrouck A; De Rijck J; Hendrix J; Vandekerckhove L; Voet A; De Maeyer M; Witvrouw M; Engelborghs Y; Christ F; Gijsbers R; Debyser Z
    PLoS Pathog; 2007 Mar; 3(3):e47. PubMed ID: 17397262
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus.
    Vandekerckhove L; Christ F; Van Maele B; De Rijck J; Gijsbers R; Van den Haute C; Witvrouw M; Debyser Z
    J Virol; 2006 Feb; 80(4):1886-96. PubMed ID: 16439544
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.
    Vanegas M; Llano M; Delgado S; Thompson D; Peretz M; Poeschla E
    J Cell Sci; 2005 Apr; 118(Pt 8):1733-43. PubMed ID: 15797927
    [TBL] [Abstract][Full Text] [Related]  

  • 11. LEDGIN-mediated Inhibition of Integrase-LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV.
    Vranckx LS; Demeulemeester J; Saleh S; Boll A; Vansant G; Schrijvers R; Weydert C; Battivelli E; Verdin E; Cereseto A; Christ F; Gijsbers R; Debyser Z
    EBioMedicine; 2016 Jun; 8():248-264. PubMed ID: 27428435
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
    Le Rouzic E; Bonnard D; Chasset S; Bruneau JM; Chevreuil F; Le Strat F; Nguyen J; Beauvoir R; Amadori C; Brias J; Vomscheid S; Eiler S; Lévy N; Delelis O; Deprez E; Saïb A; Zamborlini A; Emiliani S; Ruff M; Ledoussal B; Moreau F; Benarous R
    Retrovirology; 2013 Nov; 10():144. PubMed ID: 24261564
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-based virtual screening toward the discovery of novel inhibitors for impeding the protein-protein interaction between HIV-1 integrase and human lens epithelium-derived growth factor (LEDGF/p75).
    Panwar U; Singh SK
    J Biomol Struct Dyn; 2018 Sep; 36(12):3199-3217. PubMed ID: 28948865
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Allosteric inhibition of human immunodeficiency virus integrase: late block during viral replication and abnormal multimerization involving specific protein domains.
    Gupta K; Brady T; Dyer BM; Malani N; Hwang Y; Male F; Nolte RT; Wang L; Velthuisen E; Jeffrey J; Van Duyne GD; Bushman FD
    J Biol Chem; 2014 Jul; 289(30):20477-88. PubMed ID: 24904063
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase.
    Zheng Y; Ao Z; Jayappa KD; Yao X
    Virol J; 2010 Mar; 7():68. PubMed ID: 20331877
    [TBL] [Abstract][Full Text] [Related]  

  • 16. LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.
    Maertens G; Cherepanov P; Pluymers W; Busschots K; De Clercq E; Debyser Z; Engelborghs Y
    J Biol Chem; 2003 Aug; 278(35):33528-39. PubMed ID: 12796494
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication.
    De Rijck J; Vandekerckhove L; Gijsbers R; Hombrouck A; Hendrix J; Vercammen J; Engelborghs Y; Christ F; Debyser Z
    J Virol; 2006 Dec; 80(23):11498-509. PubMed ID: 16987986
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 1,2,3,4-Tetrahydroisoquinolines as inhibitors of HIV-1 integrase and human LEDGF/p75 interaction.
    George A; Gopi Krishna Reddy A; Satyanarayana G; Raghavendra NK
    Chem Biol Drug Des; 2018 Jun; 91(6):1133-1140. PubMed ID: 29405651
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells.
    Balakrishnan M; Yant SR; Tsai L; O'Sullivan C; Bam RA; Tsai A; Niedziela-Majka A; Stray KM; Sakowicz R; Cihlar T
    PLoS One; 2013; 8(9):e74163. PubMed ID: 24040198
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of the LEDGF/p75 binding site in HIV-1 integrase.
    Busschots K; Voet A; De Maeyer M; Rain JC; Emiliani S; Benarous R; Desender L; Debyser Z; Christ F
    J Mol Biol; 2007 Feb; 365(5):1480-92. PubMed ID: 17137594
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.