BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

191 related articles for article (PubMed ID: 21275429)

  • 1. Polymorphism of the epidermal growth factor receptor extracellular ligand binding domain: the dimer interface depends on domain stabilization.
    Zhang Z; Wriggers W
    Biochemistry; 2011 Mar; 50(12):2144-56. PubMed ID: 21275429
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ligand-binding enhances the affinity of dimerization of the extracellular domain of the epidermal growth factor receptor.
    Odaka M; Kohda D; Lax I; Schlessinger J; Inagaki F
    J Biochem; 1997 Jul; 122(1):116-21. PubMed ID: 9276679
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation.
    Zhou M; Felder S; Rubinstein M; Hurwitz DR; Ullrich A; Lax I; Schlessinger J
    Biochemistry; 1993 Aug; 32(32):8193-8. PubMed ID: 8347619
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular determinants of epidermal growth factor binding: a molecular dynamics study.
    Sanders JM; Wampole ME; Thakur ML; Wickstrom E
    PLoS One; 2013; 8(1):e54136. PubMed ID: 23382875
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In-cell structural dynamics of an EGF receptor during ligand-induced dimer-oligomer transition.
    Kozer N; Clayton AHA
    Eur Biophys J; 2020 Jan; 49(1):21-37. PubMed ID: 31740999
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling.
    Pascarelli S; Merzhakupova D; Uechi GI; Laurino P
    J Biol Chem; 2021 Jul; 297(1):100872. PubMed ID: 34126069
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Two EGF molecules contribute additively to stabilization of the EGFR dimer.
    Lemmon MA; Bu Z; Ladbury JE; Zhou M; Pinchasi D; Lax I; Engelman DM; Schlessinger J
    EMBO J; 1997 Jan; 16(2):281-94. PubMed ID: 9029149
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of the epidermal growth factor receptor: a series of twists and turns.
    Poger D; Mark AE
    Biochemistry; 2014 Apr; 53(16):2710-21. PubMed ID: 24697572
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of N-glycosylation in EGFR ectodomain ligand binding.
    Azimzadeh Irani M; Kannan S; Verma C
    Proteins; 2017 Aug; 85(8):1529-1549. PubMed ID: 28486782
    [TBL] [Abstract][Full Text] [Related]  

  • 10. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.
    Ferguson KM; Berger MB; Mendrola JM; Cho HS; Leahy DJ; Lemmon MA
    Mol Cell; 2003 Feb; 11(2):507-17. PubMed ID: 12620237
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation.
    Macdonald-Obermann JL; Pike LJ
    J Biol Chem; 2014 Sep; 289(38):26178-26188. PubMed ID: 25086039
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Anti-EGFR antibody 528 binds to domain III of EGFR at a site shifted from the cetuximab epitope.
    Makabe K; Yokoyama T; Uehara S; Uchikubo-Kamo T; Shirouzu M; Kimura K; Tsumoto K; Asano R; Tanaka Y; Kumagai I
    Sci Rep; 2021 Mar; 11(1):5790. PubMed ID: 33707468
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.
    Garrett TP; McKern NM; Lou M; Elleman TC; Adams TE; Lovrecz GO; Zhu HJ; Walker F; Frenkel MJ; Hoyne PA; Jorissen RN; Nice EC; Burgess AW; Ward CW
    Cell; 2002 Sep; 110(6):763-73. PubMed ID: 12297049
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Conformational stability of the epidermal growth factor (EGF) receptor as influenced by glycosylation, dimerization and EGF hormone binding.
    Taylor ES; Pol-Fachin L; Lins RD; Lower SK
    Proteins; 2017 Apr; 85(4):561-570. PubMed ID: 28019699
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A 40-kDa epidermal growth factor/transforming growth factor alpha-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor.
    Kohda D; Odaka M; Lax I; Kawasaki H; Suzuki K; Ullrich A; Schlessinger J; Inagaki F
    J Biol Chem; 1993 Jan; 268(3):1976-81. PubMed ID: 8420971
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains.
    Ogiso H; Ishitani R; Nureki O; Fukai S; Yamanaka M; Kim JH; Saito K; Sakamoto A; Inoue M; Shirouzu M; Yokoyama S
    Cell; 2002 Sep; 110(6):775-87. PubMed ID: 12297050
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
    Jura N; Shan Y; Cao X; Shaw DE; Kuriyan J
    Proc Natl Acad Sci U S A; 2009 Dec; 106(51):21608-13. PubMed ID: 20007378
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural basis for negative cooperativity in growth factor binding to an EGF receptor.
    Alvarado D; Klein DE; Lemmon MA
    Cell; 2010 Aug; 142(4):568-79. PubMed ID: 20723758
    [TBL] [Abstract][Full Text] [Related]  

  • 19. EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
    Needham SR; Roberts SK; Arkhipov A; Mysore VP; Tynan CJ; Zanetti-Domingues LC; Kim ET; Losasso V; Korovesis D; Hirsch M; Rolfe DJ; Clarke DT; Winn MD; Lajevardipour A; Clayton AH; Pike LJ; Perani M; Parker PJ; Shan Y; Shaw DE; Martin-Fernandez ML
    Nat Commun; 2016 Oct; 7():13307. PubMed ID: 27796308
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain.
    Lax I; Mitra AK; Ravera C; Hurwitz DR; Rubinstein M; Ullrich A; Stroud RM; Schlessinger J
    J Biol Chem; 1991 Jul; 266(21):13828-33. PubMed ID: 1856216
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.