These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
480 related articles for article (PubMed ID: 21277936)
1. Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors. Batista A; Barata JT; Raderschall E; Sallan SE; Carlesso N; Nadler LM; Cardoso AA Exp Hematol; 2011 Apr; 39(4):457-472.e3. PubMed ID: 21277936 [TBL] [Abstract][Full Text] [Related]
2. Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Vega F; Medeiros LJ; Leventaki V; Atwell C; Cho-Vega JH; Tian L; Claret FX; Rassidakis GZ Cancer Res; 2006 Jul; 66(13):6589-97. PubMed ID: 16818631 [TBL] [Abstract][Full Text] [Related]
3. Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells. Ikezoe T; Nishioka C; Bandobashi K; Yang Y; Kuwayama Y; Adachi Y; Takeuchi T; Koeffler HP; Taguchi H Leuk Res; 2007 May; 31(5):673-82. PubMed ID: 17007924 [TBL] [Abstract][Full Text] [Related]
4. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Takeuchi H; Kondo Y; Fujiwara K; Kanzawa T; Aoki H; Mills GB; Kondo S Cancer Res; 2005 Apr; 65(8):3336-46. PubMed ID: 15833867 [TBL] [Abstract][Full Text] [Related]
5. Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR. Dutton A; Reynolds GM; Dawson CW; Young LS; Murray PG J Pathol; 2005 Mar; 205(4):498-506. PubMed ID: 15714459 [TBL] [Abstract][Full Text] [Related]
6. Rapamycin, the mTOR kinase inhibitor, sensitizes acute myeloid leukemia cells, HL-60 cells, to the cytotoxic effect of arabinozide cytarabine. Janus A; Linke A; Cebula B; Robak T; Smolewski P Anticancer Drugs; 2009 Sep; 20(8):693-701. PubMed ID: 19584709 [TBL] [Abstract][Full Text] [Related]
7. Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway. Marzec M; Kasprzycka M; Liu X; El-Salem M; Halasa K; Raghunath PN; Bucki R; Wlodarski P; Wasik MA Oncogene; 2007 Aug; 26(38):5606-14. PubMed ID: 17353907 [TBL] [Abstract][Full Text] [Related]
8. Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma. Ewald F; Grabinski N; Grottke A; Windhorst S; Nörz D; Carstensen L; Staufer K; Hofmann BT; Diehl F; David K; Schumacher U; Nashan B; Jücker M Int J Cancer; 2013 Nov; 133(9):2065-76. PubMed ID: 23588885 [TBL] [Abstract][Full Text] [Related]
9. The dual kinase inhibitor NVP-BEZ235 in combination with cytotoxic drugs exerts anti-proliferative activity towards acute lymphoblastic leukemia cells. Schult C; Dahlhaus M; Glass A; Fischer K; Lange S; Freund M; Junghanss C Anticancer Res; 2012 Feb; 32(2):463-74. PubMed ID: 22287733 [TBL] [Abstract][Full Text] [Related]
11. Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosis in vitro and in a mesenchymal stem cell simulated drug-resistant microenvironment via Akt/mammalian target of rapamycin and extracellular signal-related kinase signaling pathways. Wu KN; Zhao YM; He Y; Wang BS; Du KL; Fu S; Hu KM; Zhang LF; Liu LZ; Hu YX; Wang YJ; Huang H Leuk Lymphoma; 2014 Mar; 55(3):668-76. PubMed ID: 23741975 [TBL] [Abstract][Full Text] [Related]
12. Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia. Alameen AA; Simioni C; Martelli AM; Zauli G; Ultimo S; McCubrey JA; Gonelli A; Marisi G; Ulivi P; Capitani S; Neri LM Oncotarget; 2016 Aug; 7(34):55690-55703. PubMed ID: 27494886 [TBL] [Abstract][Full Text] [Related]
13. Calcineurin complex isolated from T-cell acute lymphoblastic leukemia (T-ALL) cells identifies new signaling pathways including mTOR/AKT/S6K whose inhibition synergize with calcineurin inhibition to promote T-ALL cell death. Tosello V; Saccomani V; Yu J; Bordin F; Amadori A; Piovan E Oncotarget; 2016 Jul; 7(29):45715-45729. PubMed ID: 27304189 [TBL] [Abstract][Full Text] [Related]
14. A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia. Chiarini F; Lonetti A; Teti G; Orsini E; Bressanin D; Cappellini A; Ricci F; Tazzari PL; Ognibene A; Falconi M; Pagliaro P; Iacobucci I; Martinelli G; Amadori S; McCubrey JA; Martelli AM Oncotarget; 2012 Dec; 3(12):1615-28. PubMed ID: 23271044 [TBL] [Abstract][Full Text] [Related]
15. Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival. Hartmann W; Küchler J; Koch A; Friedrichs N; Waha A; Endl E; Czerwitzki J; Metzger D; Steiner S; Wurst P; Leuschner I; von Schweinitz D; Buettner R; Pietsch T Clin Cancer Res; 2009 Jul; 15(14):4538-45. PubMed ID: 19584164 [TBL] [Abstract][Full Text] [Related]
16. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Sun SY; Rosenberg LM; Wang X; Zhou Z; Yue P; Fu H; Khuri FR Cancer Res; 2005 Aug; 65(16):7052-8. PubMed ID: 16103051 [TBL] [Abstract][Full Text] [Related]
17. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity. deGraffenried LA; Friedrichs WE; Russell DH; Donzis EJ; Middleton AK; Silva JM; Roth RA; Hidalgo M Clin Cancer Res; 2004 Dec; 10(23):8059-67. PubMed ID: 15585641 [TBL] [Abstract][Full Text] [Related]
18. Torin2 Potentiates Anticancer Effects on Adult T-Cell Leukemia/Lymphoma by Inhibiting Mammalian Target of Rapamycin. Watanabe T; Sato A; Kobayashi-Watanabe N; Sueoka-Aragane N; Kimura S; Sueoka E Anticancer Res; 2016 Jan; 36(1):95-102. PubMed ID: 26722032 [TBL] [Abstract][Full Text] [Related]
19. PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response. Shepherd C; Banerjee L; Cheung CW; Mansour MR; Jenkinson S; Gale RE; Khwaja A Leukemia; 2013 Mar; 27(3):650-60. PubMed ID: 23038273 [TBL] [Abstract][Full Text] [Related]
20. Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. Brunn GJ; Williams J; Sabers C; Wiederrecht G; Lawrence JC; Abraham RT EMBO J; 1996 Oct; 15(19):5256-67. PubMed ID: 8895571 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]