BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

167 related articles for article (PubMed ID: 21280624)

  • 1. N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.
    Casagrande V; Salvati E; Alvino A; Bianco A; Ciammaichella A; D'Angelo C; Ginnari-Satriani L; Serrilli AM; Iachettini S; Leonetti C; Neidle S; Ortaggi G; Porru M; Rizzo A; Franceschin M; Biroccio A
    J Med Chem; 2011 Mar; 54(5):1140-56. PubMed ID: 21280624
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.
    Franceschin M; Rizzo A; Casagrande V; Salvati E; Alvino A; Altieri A; Ciammaichella A; Iachettini S; Leonetti C; Ortaggi G; Porru M; Bianco A; Biroccio A
    ChemMedChem; 2012 Dec; 7(12):2144-54. PubMed ID: 23097341
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase.
    D'Ambrosio D; Reichenbach P; Micheli E; Alvino A; Franceschin M; Savino M; Lingner J
    Biochimie; 2012 Mar; 94(3):854-63. PubMed ID: 22182489
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.
    Che T; Chen SB; Tu JL; Wang B; Wang YQ; Zhang Y; Wang J; Wang ZQ; Zhang ZP; Ou TM; Zhao Y; Tan JH; Huang ZS
    J Med Chem; 2018 Apr; 61(8):3436-3453. PubMed ID: 29618208
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands.
    Collie GW; Promontorio R; Hampel SM; Micco M; Neidle S; Parkinson GN
    J Am Chem Soc; 2012 Feb; 134(5):2723-31. PubMed ID: 22280460
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.
    Moore MJ; Schultes CM; Cuesta J; Cuenca F; Gunaratnam M; Tanious FA; Wilson WD; Neidle S
    J Med Chem; 2006 Jan; 49(2):582-99. PubMed ID: 16420044
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Selective G-quadruplex ligands: the significant role of side chain charge density in a series of perylene derivatives.
    Micheli E; Lombardo CM; D'Ambrosio D; Franceschin M; Neidle S; Savino M
    Bioorg Med Chem Lett; 2009 Jul; 19(14):3903-8. PubMed ID: 19376705
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.
    Musumeci D; Amato J; Zizza P; Platella C; Cosconati S; Cingolani C; Biroccio A; Novellino E; Randazzo A; Giancola C; Pagano B; Montesarchio D
    Biochim Biophys Acta Gen Subj; 2017 May; 1861(5 Pt B):1341-1352. PubMed ID: 28130159
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells.
    Sidibe A; Hamon F; Largy E; Gomez D; Teulade-Fichou MP; Trentesaux C; Riou JF
    Biochimie; 2012 Dec; 94(12):2559-68. PubMed ID: 22796264
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes.
    Sparapani S; Haider SM; Doria F; Gunaratnam M; Neidle S
    J Am Chem Soc; 2010 Sep; 132(35):12263-72. PubMed ID: 20718414
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents.
    Cheng MK; Modi C; Cookson JC; Hutchinson I; Heald RA; McCarroll AJ; Missailidis S; Tanious F; Wilson WD; Mergny JL; Laughton CA; Stevens MF
    J Med Chem; 2008 Feb; 51(4):963-75. PubMed ID: 18247546
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis of 4,5-diazafluorene derivatives and their anticancer activity via targeting telomeric DNA G-quadruplex.
    Zhou K; Liu J; Xiong X; Cheng M; Hu X; Narva S; Zhao X; Wu Y; Zhang W
    Eur J Med Chem; 2019 Sep; 178():484-499. PubMed ID: 31202994
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dimeric aryl-substituted imidazoles may inhibit ALT cancer by targeting the multimeric G-quadruplex in telomere.
    Hu MH; Lin XT; Liu B; Tan JH
    Eur J Med Chem; 2020 Jan; 186():111891. PubMed ID: 31759730
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage.
    Franceschin M; Nocioni D; Biroccio A; Micheli E; Cacchione S; Cingolani C; Venditti A; Zizza P; Bianco A; Altieri A
    Org Biomol Chem; 2014 Dec; 12(47):9572-82. PubMed ID: 25363232
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Phenanthroline-bis-oxazole ligands for binding and stabilization of G-quadruplexes.
    Medeiros-Silva J; Guédin A; Salgado GF; Mergny JL; Queiroz JA; Cabrita EJ; Cruz C
    Biochim Biophys Acta Gen Subj; 2017 May; 1861(5 Pt B):1281-1292. PubMed ID: 27865994
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evaluation of binding of perylene diimide and benzannulated perylene diimide ligands to DNA by electrospray ionization mass spectrometry.
    Mazzitelli CL; Brodbelt JS; Kern JT; Rodriguez M; Kerwin SM
    J Am Soc Mass Spectrom; 2006 Apr; 17(4):593-604. PubMed ID: 16503153
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Disubstituted 2-phenyl-benzopyranopyrimidine derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.
    Wu WB; Chen SH; Hou JQ; Tan JH; Ou TM; Huang SL; Li D; Gu LQ; Huang ZS
    Org Biomol Chem; 2011 Apr; 9(8):2975-86. PubMed ID: 21373680
    [TBL] [Abstract][Full Text] [Related]  

  • 18. G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells.
    Zhou WJ; Deng R; Zhang XY; Feng GK; Gu LQ; Zhu XF
    Mol Cancer Ther; 2009 Dec; 8(12):3203-13. PubMed ID: 19996277
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition.
    Sissi C; Lucatello L; Paul Krapcho A; Maloney DJ; Boxer MB; Camarasa MV; Pezzoni G; Menta E; Palumbo M
    Bioorg Med Chem; 2007 Jan; 15(1):555-62. PubMed ID: 17035038
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence.
    Di Leva FS; Zizza P; Cingolani C; D'Angelo C; Pagano B; Amato J; Salvati E; Sissi C; Pinato O; Marinelli L; Cavalli A; Cosconati S; Novellino E; Randazzo A; Biroccio A
    J Med Chem; 2013 Dec; 56(23):9646-54. PubMed ID: 24256368
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.