BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

205 related articles for article (PubMed ID: 21294720)

  • 1. Cellular localization and functional significance of CYP3A4 in the human epileptic brain.
    Ghosh C; Marchi N; Desai NK; Puvenna V; Hossain M; Gonzalez-Martinez J; Alexopoulos AV; Janigro D
    Epilepsia; 2011 Mar; 52(3):562-71. PubMed ID: 21294720
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model.
    Ghosh C; Hossain M; Mishra S; Khan S; Gonzalez-Martinez J; Marchi N; Janigro D; Bingaman W; Najm I
    Epilepsia; 2018 Nov; 59(11):2049-2060. PubMed ID: 30264400
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Significance of MDR1 and multiple drug resistance in refractory human epileptic brain.
    Marchi N; Hallene KL; Kight KM; Cucullo L; Moddel G; Bingaman W; Dini G; Vezzani A; Janigro D
    BMC Med; 2004 Oct; 2():37. PubMed ID: 15473912
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains.
    Ghosh C; Hossain M; Puvenna V; Martinez-Gonzalez J; Alexopolous A; Janigro D; Marchi N
    Epilepsia; 2013 Sep; 54(9):1562-70. PubMed ID: 23865846
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study.
    Ghosh C; Hossain M; Spriggs A; Ghosh A; Grant GA; Marchi N; Perucca E; Janigro D
    Epilepsia; 2015 Mar; 56(3):439-49. PubMed ID: 25656284
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow.
    Ghosh C; Gonzalez-Martinez J; Hossain M; Cucullo L; Fazio V; Janigro D; Marchi N
    Epilepsia; 2010 Aug; 51(8):1408-17. PubMed ID: 20074231
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain.
    Ghosh C; Marchi N; Hossain M; Rasmussen P; Alexopoulos AV; Gonzalez-Martinez J; Yang H; Janigro D
    Neurobiol Dis; 2012 Jun; 46(3):692-700. PubMed ID: 22426401
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.
    Puranik YG; Birnbaum AK; Marino SE; Ahmed G; Cloyd JC; Remmel RP; Leppik IE; Lamba JK
    Pharmacogenomics; 2013 Jan; 14(1):35-45. PubMed ID: 23252947
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Gancao (Glycyrrhizae Radix) provides the main contribution to Shaoyao-Gancao decoction on enhancements of CYP3A4 and MDR1 expression via pregnane X receptor pathway in vitro.
    Feng D; Tang T; Fan R; Luo J; Cui H; Wang Y; Gan P
    BMC Complement Altern Med; 2018 Dec; 18(1):345. PubMed ID: 30594244
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy.
    Williams S; Hossain M; Ferguson L; Busch RM; Marchi N; Gonzalez-Martinez J; Perucca E; Najm IM; Ghosh C
    Mol Neurobiol; 2019 Dec; 56(12):8392-8407. PubMed ID: 31243719
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein.
    Brimer C; Dalton JT; Zhu Z; Schuetz J; Yasuda K; Vanin E; Relling MV; Lu Y; Schuetz EG
    Pharm Res; 2000 Jul; 17(7):803-10. PubMed ID: 10990198
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Transfected MDCK cell line with enhanced expression of CYP3A4 and P-glycoprotein as a model to study their role in drug transport and metabolism.
    Kwatra D; Budda B; Vadlapudi AD; Vadlapatla RK; Pal D; Mitra AK
    Mol Pharm; 2012 Jul; 9(7):1877-86. PubMed ID: 22676443
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
    Gupta A; Mugundu GM; Desai PB; Thummel KE; Unadkat JD
    Drug Metab Dispos; 2008 Jun; 36(6):1172-80. PubMed ID: 18332086
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of sinapic acid on hepatic cytochrome P450 3A2, 2C11, and intestinal P-glycoprotein on the pharmacokinetics of oral carbamazepine in rats: Potential food/herb-drug interaction.
    Raish M; Ahmad A; Ansari MA; Alkharfy KM; Ahad A; Al-Jenoobi FI; Al-Mohizea AM; Khan A; Ali N
    Epilepsy Res; 2019 Jul; 153():14-18. PubMed ID: 30927680
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy.
    Sisodiya SM; Lin WR; Harding BN; Squier MV; Thom M
    Brain; 2002 Jan; 125(Pt 1):22-31. PubMed ID: 11834590
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.
    Wang P; Yin T; Ma HY; Liu DQ; Sheng YH; Wang C; Zhou BT
    Epilepsy Res; 2015 Nov; 117():52-7. PubMed ID: 26421491
    [TBL] [Abstract][Full Text] [Related]  

  • 17. In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6.
    Weiss J; Sawa E; Riedel KD; Haefeli WE; Mikus G
    Naunyn Schmiedebergs Arch Pharmacol; 2008 Sep; 378(3):275-82. PubMed ID: 18516595
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Induction of CYP3A4 and MDR1 gene expression by baicalin, baicalein, chlorogenic acid, and ginsenoside Rf through constitutive androstane receptor- and pregnane X receptor-mediated pathways.
    Li Y; Wang Q; Yao X; Li Y
    Eur J Pharmacol; 2010 Aug; 640(1-3):46-54. PubMed ID: 20580705
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Vascular and parenchymal mechanisms in multiple drug resistance: a lesson from human epilepsy.
    Marroni M; Marchi N; Cucullo L; Abbott NJ; Signorelli K; Janigro D
    Curr Drug Targets; 2003 May; 4(4):297-304. PubMed ID: 12699350
    [TBL] [Abstract][Full Text] [Related]  

  • 20. P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.
    Hendrikx JJ; Lagas JS; Rosing H; Schellens JH; Beijnen JH; Schinkel AH
    Int J Cancer; 2013 May; 132(10):2439-47. PubMed ID: 23090875
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.